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公开(公告)号：US07686844B2
公开(公告)日：2010-03-30
申请号：US10903907
申请日：2004-07-30
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译： 提供用于植入体内的假体瓣膜。 根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。 移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。
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公开(公告)号：US20100063577A1
公开(公告)日：2010-03-11
申请号：US12621214
申请日：2009-11-18
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Methods of implanting a prosthetic valve in a body vessel are provided. A first expandable frame member is delivered to and deployed at a point of treatment in a body vessel. A second expandable frame member is delivered to the point of treatment. The second expandable frame member has an attached graft member that forms a valve adapted to permit fluid flow through the body vessel in a first direction and to substantially prevent fluid flow through the body vessel in a second, opposite direction. After deployment of the first expandable frame member, the second expandable frame member is deployed at the point of treatment such that the second frame member is positioned radially inward of the first frame member within said body vessel to form a prosthetic valve.
摘要翻译： 提供了将人造瓣植入人体容器中的方法。 第一可膨胀框架构件被输送到身体容器中并在其处处被部署。 第二可膨胀框架构件被输送到处理点。 第二可膨胀框架构件具有附接的移植构件，其形成适于允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体容器。 在展开第一可膨胀框架构件之后，第二可膨胀框架构件在处理点处展开，使得第二框架构件位于所述主体容器内的第一框架构件的径向内侧以形成人造瓣膜。
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公开(公告)号：US07955376B2
公开(公告)日：2011-06-07
申请号：US11539925
申请日：2006-10-10
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： A medical device comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译： 医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植物构件。 支撑结构具有第一，未膨胀的构造和第二扩展构型。 约束部分适于基本上防止支撑结构实现第二扩张构型。 阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。
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公开(公告)号：US08382822B2
公开(公告)日：2013-02-26
申请号：US12574870
申请日：2009-10-07
申请人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
发明人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0021 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095
摘要： A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译： 一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶片结构，其包括一个或多个小叶，每个小叶的外边缘沿着沿着通过可扩张的第二通道推动抵靠通道的蛇形路径接合身体通道的内周 框架，而内边缘响应流体移动以限制逆行流。 任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。 在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。 在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。
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公开(公告)号：US20090216321A1
公开(公告)日：2009-08-27
申请号：US12437731
申请日：2009-05-08
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： A prosthetic valve includes a support frame, a leaflet attached to the support frame, and a bioactive agent associated with the leaflet. A first free edge of the leaflet permits fluid flow through a body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction. A second free edge of the leaflet at least partially defines an opening for permitting a controlled amount of fluid flow through the body vessel.
摘要翻译： 假体瓣膜包括支撑框架，附接到支撑框架的小叶以及与小叶相关联的生物活性剂。 小叶的第一自由边允许流体沿着第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过身体血管。 叶片的第二自由边缘至少部分地限定了允许受控量的流体流过身体容器的开口。
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公开(公告)号：US07628803B2
公开(公告)日：2009-12-08
申请号：US10642372
申请日：2003-08-15
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
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公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译： 一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展 框架，而内边缘响应流体移动以限制逆行流。 任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。 在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。 在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。
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公开(公告)号：US07544207B2
公开(公告)日：2009-06-09
申请号：US11244991
申请日：2005-10-06
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.
摘要翻译： 提供具有一种或多种生物活性剂的医疗装置用于调节通过身体血管的流体流动。 根据本发明的医疗装置可以包括包括生物活性剂的人造瓣膜。
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公开(公告)号：US07128759B2
公开(公告)日：2006-10-31
申请号：US10849639
申请日：2004-05-19
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译： 提供用于植入体内的医疗装置。 根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。 支撑结构具有第一，未膨胀的构造和第二扩展构型。 约束部分适于基本上防止支撑结构实现第二扩张构型。 阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。
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公开(公告)号：US09421096B2
公开(公告)日：2016-08-23
申请号：US13550229
申请日：2012-07-16
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that is configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure.
摘要翻译： 一种可膨胀静脉瓣，其具有支撑结构，所述支撑结构被构造成扩大与所述瓣膜结构相邻的区域，使得逆行流的流动模式以便于在所述瓣膜区域的底部冲洗所述凹穴以防止停滞的方式被修改 的体液，其在静脉系统中可导致血栓形成。 可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成扩大的口袋区域，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分 结构体。
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