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    Artificial valve prosthesis with improved flow dynamics
    4.
    发明授权
    Artificial valve prosthesis with improved flow dynamics 有权
    具有改善流动动力学的人造瓣膜假体

    公开(公告)号：US08221492B2

    公开(公告)日：2012-07-17

    申请号：US10554494

    申请日：2004-04-21

    申请人： Brian C. Case ,  Michael L. Garrison ,  Andrew Hoffa ,  Darin G. Schaeffer ,  Jacob A. Flagle

    发明人： Brian C. Case ,  Michael L. Garrison ,  Andrew Hoffa ,  Darin G. Schaeffer ,  Jacob A. Flagle

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2002/068 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0037 ,  A61F2250/0039

    摘要： An expandable venous valve having a support structure that configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.

    摘要翻译： 一种可膨胀静脉瓣，其具有支撑结构，该支撑结构被配置为扩大邻近阀结构的区域，使逆行流的流动模式以便于冲洗瓣膜区域底部的口袋的方式进行改变，以防止滞留 在静脉系统中的体液可导致血栓形成。 扩大的口袋区域可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分 结构体。 在另一组实施例中，相对的小叶与支撑框架和/或血管壁之间的附接通路包括将小叶彼此延伸接触的近端部分，并且远侧部分相对于相邻壁形成大角度， 在传单的底部创造了一个大口袋。 在一个实施例中，附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸，以产生延伸的小叶接触区域，然后沿着远侧连接支柱沿着周向和远端远离成形器，以限定传单的底部边缘。

    High pressure injection syringe
    7.
    发明申请
    High pressure injection syringe 有权

    公开(公告)号：US20060116643A1

    公开(公告)日：2006-06-01

    申请号：US11166915

    申请日：2005-06-23

    申请人： Christopher Dixon ,  Jacob Flagle ,  Andrew Hoffa ,  Joseph Lane

    发明人： Christopher Dixon ,  Jacob Flagle ,  Andrew Hoffa ,  Joseph Lane

    IPC分类号： A61M5/00

    CPC分类号： A61B17/8827 ,  A61B17/8822 ,  A61F2/44 ,  A61F2/4601 ,  A61F2310/00353

    摘要： A pressure injection syringe with an actuator that includes a plunger for pressurizing viscous fluid material within a chamber. The plunger distal tip includes a high pressure seal defined by a seal member within a seal seat. The high pressure seal is viscoselective to permit air passage therepast for aspiration, and to prohibit viscous material passage therepast during actuation of the actuator wherein high pressure is applied to the material within the chamber. The viscoselective seal may be defined for example by small axial openings in the seal seat that permit aspiration of air therepast during initial plunger insertion into the chamber, but fluid escape is prohibited by the seal member when the seal member is pressed firmly against a collar of the plunger proximally adjacent the seal seat by initial engagement of the seal member with the viscous material, thus completely sealing the chamber at the proximal end thereof.

    IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION
    8.
    发明申请
    IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
    具有约束扩张的可植入医疗装置

    公开(公告)号：US20070106372A1

    公开(公告)日：2007-05-10

    申请号：US11539925

    申请日：2006-10-10

    申请人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Andrew Hoffa ,  Michael Garrison

    发明人： Thomas Osborne ,  Brian Case ,  Jacob Flagle ,  Andrew Hoffa ,  Michael Garrison

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0026 ,  A61F2230/0095

    摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.

    摘要翻译： 提供用于植入体内的医疗装置。 根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。 支撑结构具有第一，未膨胀的构造和第二扩展构型。 约束部分适于基本上防止支撑结构实现第二扩张构型。 阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

    Artificial Valve Prosthesis with Improved Flow Dynamics
    9.
    发明申请
    Artificial Valve Prosthesis with Improved Flow Dynamics 有权
    人工瓣膜假体具有改善的流动动力学

    公开(公告)号：US20070260327A1

    公开(公告)日：2007-11-08

    申请号：US10554494

    申请日：2004-04-21

    申请人： Brian Case ,  Michael Garrison ,  Andrew Hoffa ,  Darin Schaeffer ,  Jacob Flagle

    发明人： Brian Case ,  Michael Garrison ,  Andrew Hoffa ,  Darin Schaeffer ,  Jacob Flagle

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2002/068 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0037 ,  A61F2250/0039

    摘要： An expandable venous valve having a support structure that configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.

    摘要翻译： 一种可膨胀静脉瓣，其具有支撑结构，该支撑结构被配置为扩大邻近阀结构的区域，使逆行流的流动模式以便于冲洗瓣膜区域底部的口袋的方式进行改变，以防止滞留 在静脉系统中的体液可导致血栓形成。 扩大的口袋区域可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分 结构体。 在另一组实施例中，相对的小叶与支撑框架和/或血管壁之间的附接通路包括将小叶彼此延伸接触的近端部分，并且远侧部分相对于相邻壁形成大角度， 在传单的底部创造了一个大口袋。 在一个实施例中，附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸，以产生延伸的小叶接触区域，然后沿着远侧连接支柱沿着周向和远端远离成形器，以限定传单的底部边缘。