公开(公告)号：US20050289666A1

公开(公告)日：2005-12-29

申请号：US11122494

申请日：2005-05-04

申请人： Brian Hooker ,  Keith Miller ,  Johnway Gao ,  Rodney Skeen ,  Daniel Anderson

发明人： Brian Hooker ,  Keith Miller ,  Johnway Gao ,  Rodney Skeen ,  Daniel Anderson

IPC分类号： C07K14/39 ,  A01H1/00 ,  C12N1/18 ,  C12N5/04 ,  C12N15/74 ,  C12N15/82 ,  C12P21/06

CPC分类号： C07K14/39

摘要： The invention includes an isolated promoter containing nucleotides 1827 through 2147 of SEQ ID NO.: 1. The invention also includes methods of regulating expression of a gene by fusing the isolated promoter to a coding sequence to form a fused construct, and introducing the fused construct into a host such that the promoter regulates the expression of the gene product within the host. The invention additionally includes a recombinant gene comprising an isolated promoter containing at least nucleotides 1827 through 2147 of SEQ ID NO.: 1, operably linked to a coding region encoding a gene product of interest. The invention includes a host cell containing the recombinant gene.

摘要翻译： 本发明包括含有SEQ ID NO：1的核苷酸1827至2147的分离的启动子。本发明还包括通过将分离的启动子融合到编码序列以形成融合构建体并引入融合构建体来调节基因表达的方法 使得启动子调节宿主内基因产物的表达。 本发明还包括重组基因，其包含至少包含SEQ ID NO：1的核苷酸1827至2147的分离的启动子，其可操作地连接到编码感兴趣的基因产物的编码区。 本发明包括含有重组基因的宿主细胞。

公开(公告)号：US20050060775A1

公开(公告)日：2005-03-17

申请号：US10863969

申请日：2004-06-08

申请人： Brian Hooker ,  Daniel Anderson ,  Johnway Gao ,  Ziyu Dai

发明人： Brian Hooker ,  Daniel Anderson ,  Johnway Gao ,  Ziyu Dai

IPC分类号： A01H1/00 ,  C12N15/82

CPC分类号： C12N15/8257

摘要： The invention includes methods for production of a polypeptide having factor VIII activity by introduction of a polynucleotide construct into a plant cell. The construct includes an encoding sequence for a polypeptide of coagulation factor VIII or a functional variant thereof. The plant cell is cultured or regenerated into a plant and the polypeptide or functional variant of factor VIII is expressed therein. The invention also includes vectors, plant cells, plant tissues, plants and seeds containing a polynucleotide sequence encoding a functional variant of human coagulation factor VIII. The invention further includes a recombinant DNA molecule having a promoter which is functional in plants operably linked to a coding sequence which codes for a polynucleotide having coagulation factor VIII activity.

摘要翻译： 本发明包括通过将多核苷酸构建体引入植物细胞来生产具有因子VIII活性的多肽的方法。 该构建体包含凝血因子VIII多肽或其功能变体的编码序列。 将植物细胞培养或再生成植物，并在其中表达因子VIII的多肽或功能变体。 本发明还包括含有编码人凝血因子VIII功能变体的多核苷酸序列的载体，植物细胞，植物组织，植物和种子。 本发明还包括具有启动子的重组DNA分子，该启动子在与可编码具有凝血因子VIII活性的多核苷酸的编码序列可操作地连接的植物中是功能性的。

公开(公告)号：US5982954A

公开(公告)日：1999-11-09

申请号：US955084

申请日：1997-10-21

申请人： Nuri Delen ,  Brian Hooker

发明人： Nuri Delen ,  Brian Hooker

IPC分类号： G02B27/44 ,  G03H1/08 ,  G06K9/32

CPC分类号： G02B27/4266 ,  G03H1/08

摘要： This invention provides a method and apparatus for analyzing the propagation of optical fields between arbitrarily oriented planes using full scalar diffraction theory. One aspect of the invention allows propagation between tilted planes. A second aspect allows propagation between offset planes. To analyze the propagation of an input optical field from a first plane to a second plane, the input field in the spatial domain is Fourier transformed to obtain the plane wave distribution in the spatial frequency domain. Within the spatial frequency domain the field is propagated from the first plane to the second plane by first multiplying the plane wave distribution by the spatial frequency domain phase accumulation between the first and second planes, and then converting the plane wave distribution from the coordinate system of the first plane to that of the second plane. Finally, the propagated plane wave distribution is inverse Fourier transformed to obtain the propagated optical field. This propagation sequence forms the building block for a numerical method to analyze optical systems using full scalar diffraction theory. To analyze optical systems, the input field is propagated from the plane of the source to the plane of the first optical element and the propagated optical field is multiplied by the transmittance function of the optical element. This invention further includes tolerance analysis of each parameter that affects the image quality and coupling efficiency of the optical system.

摘要翻译： 本发明提供一种用于使用全标量衍射理论来分析任意取向的平面之间的光场的传播的方法和装置。 本发明的一个方面允许在倾斜平面之间传播。 第二方面允许在偏移平面之间传播。 为了分析从第一平面到第二平面的输入光场的传播，空间域中的输入场被傅里叶变换以获得空间频域中的平面波分布。 在空间频域内，通过首先将平面波分布乘以第一和第二平面之间的空间频域相位累积，将场从第一平面传播到第二平面，然后将平面波分布从坐标系 第二架飞机的第一架飞机。 最后，传播的平面波分布进行傅里叶逆变换，以获得传播的光场。 该传播序列形成用于使用全标量衍射理论分析光学系统的数值方法的构建块。 为了分析光学系统，输入场从源的平面传播到第一光学元件的平面，并且传播的光场乘以光学元件的透射函数。 本发明还包括影响光学系统的图像质量和耦合效率的每个参数的容差分析。

公开(公告)号：US20050005324A1

公开(公告)日：2005-01-06

申请号：US10903948

申请日：2004-07-30

申请人： Ziyu Dai ,  LiFang Shi ,  Brian Hooker

发明人： Ziyu Dai ,  LiFang Shi ,  Brian Hooker

IPC分类号： C12N9/10 ,  C12N15/29 ,  C12N15/82 ,  C23C16/44 ,  C23C16/455 ,  C07H21/04 ,  C12N5/10 ,  C12N15/09 ,  C12N15/63 ,  C12N15/87

CPC分类号： C23C16/45565 ,  C12N9/1096 ,  C12N15/8237 ,  C12N15/8238 ,  C23C16/45519

摘要： There are disclosed novel pin1 gene promoter isoforms and amt gene promoter isoforms. The promoters and their functional elements may be used independently or in combination with one or more enhancer elements to increase or otherwise manipulate gene expression. The promoters disclosed may be used in Controlled Environment Agriculture for heterologous protein production. Also disclosed are methods for using the promoter and promoter elements of the instant invention, as well as vectors and transgenic plants comprising the same.

摘要翻译： 已经公开了新的pin1基因启动子同种型和amt基因启动子同种型。 启动子及其功能元件可以单独使用或与一种或多种增强子元件组合使用以增加或以其他方式操作基因表达。 所公开的启动子可用于受控环境农业用于异源蛋白质生产。 还公开了使用本发明的启动子和启动子元件以及包含其的载体和转基因植物的方法。

公开(公告)号：US06554463B2

公开(公告)日：2003-04-29

申请号：US09923065

申请日：2001-08-06

申请人： Brian Hooker ,  Joshua Friedman

发明人： Brian Hooker ,  Joshua Friedman

IPC分类号： F21V800

CPC分类号： A61C19/004 ,  A61N2005/0652 ,  G02B6/4298 ,  Y10S362/80

摘要： An optical waveguide concentrator and photocuring device with the optical waveguide concentrator having at least one solid optically transparent member for combining the output radiant energy from a plurality of optoelectronic light emitting devices mounted in a circular array facing the solid optically transparent member with the optically transparent member having an input surface, an output surface and a sloping surface intersecting the input and output surface to form an acute angle and with with each optoelectronic light emitting device having an optical axis directed parallel to or inclined relative to the longitudinal axis of the concentrator. The geometry of the solid optically transparent member may be conical or hyperbolic with the sloping surface tapered to form a tapered angle of between 5° and 15°.

公开(公告)号：US5982549A

公开(公告)日：1999-11-09

申请号：US79489

申请日：1998-05-15

申请人： Kenneth Kubala ,  Brian Hooker ,  Lindon Lewis ,  Andrew Hatch

发明人： Kenneth Kubala ,  Brian Hooker ,  Lindon Lewis ,  Andrew Hatch

IPC分类号： G02B23/12 ,  G02B27/10 ,  G02B21/18 ,  G02B23/00 ,  G02B27/02

CPC分类号： G02B23/12

摘要： This invention provides a vision system that increases the field of view of an electronic binocular system without degrading image quality or requiring extremely large format sensors or displays. The vision system comprises an imaging device coupled with a viewing device. The imaging device comprises a compression lens and an image sensor. The viewing device comprises an image display and a decompression lens. The compression lens matches the optical distortion to the human visual acuity curve for field positions greater than an angle .theta.. Below angle .theta. there is substantially no distortion. The optimum angle .theta. depends on the application. For an average individual viewing a landscape the angle .theta. is about 10.degree.. For different viewing objects, the optimum angle .theta. varies from about 5.degree. to about 15.degree.. The image sensor can be infrared sensitive for infrared viewing. For low-light level viewing an image intensifier can be positioned between the compression lens and the image sensor. The imaging device can be connected to the viewing device in a unitary structure or the imaging device can be remote from the viewing device. The compression lens and the decompression lens are compound lenses, each comprising a plurality of component lenses. One or more surface of one or more component lens can be aspheric.

摘要翻译： 本发明提供一种增加电子双目系统的视野而不降低图像质量或需要极大格式的传感器或显示器的视觉系统。 视觉系统包括与观看装置耦合的成像装置。 成像装置包括压缩透镜和图像传感器。 观察装置包括图像显示器和减压透镜。 压缩透镜将光学畸变与大于角度θ的场位置的人视力曲线相匹配。 角度θ以下基本上没有失真。 最佳角度θ取决于应用。 对于观看景观的平均个体，角度θ约为10度。 对于不同的观察对象，最佳角度θ在约5°至约15°之间变化。 图像传感器可以对红外线进行红外检测。 对于低光级别的观看，图像增强器可以位于压缩透镜和图像传感器之间。 成像装置可以以单一结构连接到观察装置，或者成像装置可以远离观察装置。 压缩透镜和减压透镜是复合透镜，每个透镜包括多个分量透镜。 一个或多个组件透镜的一个或多个表面可以是非球面的。