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    MEDICAL IMPLANT INCLUDING A MAGNESIUM-BASED TIE LAYER
    2.
    发明申请
    MEDICAL IMPLANT INCLUDING A MAGNESIUM-BASED TIE LAYER 有权
    医疗植入物包括一个基于镁的层状物

    公开(公告)号：US20120095548A1

    公开(公告)日：2012-04-19

    申请号：US13238234

    申请日：2011-09-21

    申请人： Daniel J. Gregorich ,  Michael P. Meyer ,  Jonathan S. Stinson

    发明人： Daniel J. Gregorich ,  Michael P. Meyer ,  Jonathan S. Stinson

    IPC分类号： A61F2/82 ,  B05D7/00

    CPC分类号： A61L31/022 ,  A61L27/04 ,  A61L27/306 ,  A61L27/54 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/00

    摘要： A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface.

    摘要翻译： 医疗植入物包括金属基底，连接层，以及覆盖连接层的外表面的至少第一层。 粘结层结合到金属基底表面的至少一部分上。 连接层包括镁或镁基合金。 连接层可以具有包括树枝状晶粒的外表面。 连接层可以具有由孔，突出的颗粒结构和/或突出的颗粒限定的粗糙的外表面。 在医疗装置上制造粘结层的方法包括将镁或镁基合金施加到医疗装置上并冷却镁或镁基合金以产生粗糙的外表面。

    Medical implant including a magnesium-based tie layer
    3.
    发明授权
    Medical implant including a magnesium-based tie layer 有权
    医疗植入物包括镁基粘结层

    公开(公告)号：US08956403B2

    公开(公告)日：2015-02-17

    申请号：US13238234

    申请日：2011-09-21

    申请人： Daniel J. Gregorich ,  Michael P. Meyer ,  Jonathan S. Stinson

    发明人： Daniel J. Gregorich ,  Michael P. Meyer ,  Jonathan S. Stinson

    IPC分类号： A61F2/02 ,  A61L31/02 ,  A61L27/04 ,  A61L27/30 ,  A61L27/54 ,  A61L31/08 ,  A61L31/16

    CPC分类号： A61L31/022 ,  A61L27/04 ,  A61L27/306 ,  A61L27/54 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/00

    摘要： A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface.

    摘要翻译： 医疗植入物包括金属基底，连接层，以及覆盖连接层的外表面的至少第一层。 粘结层结合到金属基底表面的至少一部分上。 连接层包括镁或镁基合金。 连接层可以具有包括树枝状晶粒的外表面。 连接层可以具有由孔，突出的颗粒结构和/或突出的颗粒限定的粗糙的外表面。 在医疗装置上制造粘结层的方法包括将镁或镁基合金施加到医疗装置上并冷却镁或镁基合金以产生粗糙的外表面。

    BALLOON CATHETER
    7.
    发明申请
    BALLOON CATHETER 有权
    气球导管

    公开(公告)号：US20110009942A1

    公开(公告)日：2011-01-13

    申请号：US12709258

    申请日：2010-02-19

    申请人： Daniel J. Gregorich ,  Eric Petersen ,  Adam D. Grovender ,  David D. Groneberg

    发明人： Daniel J. Gregorich ,  Eric Petersen ,  Adam D. Grovender ,  David D. Groneberg

    IPC分类号： A61F2/82

    CPC分类号： A61M25/104 ,  A61F2/856 ,  A61F2/954 ,  A61F2/958 ,  A61F2250/0029 ,  A61M25/0051 ,  A61M25/0052 ,  A61M25/0053 ,  A61M25/0054 ,  A61M25/1011 ,  A61M2025/0183 ,  A61M2025/1056

    摘要： Balloon catheters and stent delivery systems including bifurcated stent delivery systems are disclosed. An example bifurcated stent delivery system may include an elongate shaft including a proximal section, a midshaft section, and a distal section. The proximal section may include a tubular member having a plurality of slots formed therein. The slots may be arranged in one or more sections having differing slot densities. The midshaft section may include a guidewire port in fluid communication with a guidewire lumen formed in the shaft. A main branch balloon may be coupled to the shaft. A side branch balloon may be disposed adjacent to the main branch balloon. A stent may be disposed on the main branch balloon and on the side branch balloon.

    摘要翻译： 公开了包括分叉支架输送系统的球囊导管和支架输送系统。 示例性分叉支架输送系统可以包括细长轴，其包括近端部分，中间部分和远端部分。 近端部分可以包括其中形成有多个狭槽的管状构件。 槽可以布置在具有不同槽密度的一个或多个部分中。 中轴部分可以包括与形成在轴中的导丝管腔流体连通的导丝端口。 主分支气囊可以联接到轴。 侧分支气囊可以邻近主分支气囊设置。 支架可以设置在主分支气囊和侧支气囊上。

    DIFFERENTIAL DRUG RELEASE FROM A MEDICAL DEVICE
    8.
    发明申请
    DIFFERENTIAL DRUG RELEASE FROM A MEDICAL DEVICE 审中-公开
    来自医疗器械的差别药物释放

    公开(公告)号：US20080215136A1

    公开(公告)日：2008-09-04

    申请号：US11953969

    申请日：2007-12-11

    申请人： Daniel J. Gregorich ,  Mike Meyer

    发明人： Daniel J. Gregorich ,  Mike Meyer

    IPC分类号： A61F2/82 ,  A61F2/06

    CPC分类号： A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/45 ,  A61L2300/602

    摘要： The invention relates to a medical device, such as an intravascular stent, useful for delivering two or more therapeutic agents to a body tissue of a patient at different rates, and methods for making and using such medical device. The medical device includes a substrate and/or coating having a plurality of pores, dispersed in said pores are a plurality of a first and second therapeutic agents, wherein said first therapeutic agent is bonded to one or more molecule(s) of a first material and the second therapeutic agent bonded to one or more molecule(s) of a second material, such that when the medical device, is in use (e.g., implanted into a body lumen such as a blood vessel), bonded first therapeutic agent is released from the medical device at a rate that is slower than the rate at which the bonded second therapeutic agent is released from the medical device.

    摘要翻译： 本发明涉及可用于将两种或更多种治疗剂以不同速率递送到患者的身体组织的医疗装置，例如血管内支架，以及制造和使用该医疗装置的方法。 医疗装置包括具有多个孔的基底和/或涂层，分散在所述孔中是多个第一和第二治疗剂，其中所述第一治疗剂与第一物质的一个或多个分子结合 和第二治疗剂，其结合到第二材料的一个或多个分子，使得当使用医疗器械（例如，植入体腔诸如血管）时，释放接合的第一治疗剂 以比从粘合的第二治疗剂从医疗装置释放的速度慢的速度从医疗装置开始。