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    ENTERIC COATING COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    1.
    发明申请
    ENTERIC COATING COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
    选择性涂料组合物及其制备方法和使用方法

    公开(公告)号：US20130115285A1

    公开(公告)日：2013-05-09

    申请号：US13578289

    申请日：2011-02-12

    Applicant: Eric H. Van Ness ,  Beverly A. Schad ,  Thomas C. Riley ,  Brian K. Cheng

    Inventor： Eric H. Van Ness ,  Beverly A. Schad ,  Thomas C. Riley ,  Brian K. Cheng

    IPC: A61K47/36 ,  A61K47/34

    CPC classification number: A61K47/36 ,  A23L29/256 ,  A23L29/275 ,  A23P20/105 ,  A23V2002/00 ,  A61K47/34 ,  A23V2200/22 ,  A23V2250/5026

    Abstract: An enteric coating composition including about 0.01% to about 10% resin and about 0.01% to about 10% polymer. The enteric coating composition may be applied to a substrate, such as a pharmaceutical, nutraceutical, fruit, vegetable, agricultural product, or industrial product, to form an enteric coating on the substrate. Also provided is a multiple-component system having a first component including a resin and a second component including a polymer, wherein mixing the first component and the second component forms an enteric coating composition having about 0.01% to about 10% resin and about 0.01% to about 10% polymer. Methods for coating a substrate with the enteric coating compositions are also provided.

    Abstract translation: 包括约0.01％至约10％的树脂和约0.01％至约10％的聚合物的肠溶包衣组合物。 肠溶剂组合物可以施用于基质如药物，保健品，水果，蔬菜，农产品或工业产品，以在基材上形成肠溶衣。 还提供了具有包括树脂的第一组分和包含聚合物的第二组分的多组分体系，其中混合第一组分和第二组分形成具有约0.01％至约10％树脂和约0.01％ 至约10％的聚合物。 还提供了用肠溶衣组合物涂覆底物的方法。

    Process for Synthesizing Remifentanil
    2.
    发明申请
    Process for Synthesizing Remifentanil 审中-公开
    合成瑞芬太尼的方法

    公开(公告)号：US20080319196A1

    公开(公告)日：2008-12-25

    申请号：US12093517

    申请日：2006-10-23

    Applicant: Brian K. Cheng

    Inventor： Brian K. Cheng

    IPC: C07D211/56

    CPC classification number: C07D211/66

    Abstract: An improved process for synthesizing opiate or opioid analgesics and anesthetics, and intermediates thereof is provided. In particular, processes of synthesizing intermediates for use in the preparation of synthetic opiate or opioid compounds such as, for example, remifentanil, carfentanil, sufentanil, fentanyl, and alfentanil are disclosed. The preparation process requires fewer steps, and results in reduced costs and higher efficiency than processes known in the art for producing remifentanil and carfentanil.

    Abstract translation: 提供了一种用于合成鸦片剂或阿片类止痛剂和麻醉剂的改进方法及其中间体。 特别地，公开了合成用于制备合成阿片剂或阿片样物质的中间体的方法，例如瑞芬太尼，卡芬太尼，舒芬太尼，芬太尼和阿芬太尼。 制备方法需要更少的步骤，并且导致降低成本并且比本领域已知的用于生产瑞芬太尼和卡芬太尼的方法更高的效率。

    Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
    3.
    发明授权
    Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders 失效
    含有吲哚-2-羧酸盐化合物的组合物，用于治疗中枢神经系统疾病

    公开(公告)号：US5137910A

    公开(公告)日：1992-08-11

    申请号：US484530

    申请日：1990-03-01

    Applicant: Nancy M. Gray ,  Brian K. Cheng ,  William F. Hood ,  Michael S. Dappen ,  Alex A. Cordi

    Inventor： Nancy M. Gray ,  Brian K. Cheng ,  William F. Hood ,  Michael S. Dappen ,  Alex A. Cordi

    IPC: A61K31/405

    CPC classification number: A61K31/405

    Abstract: Compositions containing certain indole-2-carboxylate compounds and derivatives are described as being therapeutically effective in treatment of CNS disorders resulting from neurotoxic damage or neurodegenerative diseases, particularly those CNS disorders resulting from ischemic events. Preferred compounds are of the formula ##STR1## wherein each of R.sup.5 and R.sup.6 is independently selected from hydrido, bromo, chloro and fluoro, and wherein each of R.sup.10 and R.sup.12 is independently selected from hydrido and lower alkyl, and pharmaceutically-acceptable salts thereof.

    Abstract translation: 含有某些吲哚-2-羧酸酯化合物和衍生物的组合物被描述为治疗由神经毒性损伤或神经变性疾病，特别是由缺血事件引起的CNS障碍引起的CNS障碍的治疗有效性。 优选的化合物具有式“IMAGE”，其中R 5和R 6各自独立地选自氢，溴，氯和氟，并且其中R 10和R 12各自独立地选自氢和低级烷基及其药学上可接受的盐。

    Process for the preparation of undoped polyaniline via para-haloaniline
    6.
    发明授权
    Process for the preparation of undoped polyaniline via para-haloaniline 失效
    通过对卤代苯胺制备未掺杂聚苯胺的方法

    公开(公告)号：US5852161A

    公开(公告)日：1998-12-22

    申请号：US918948

    申请日：1997-08-25

    Applicant: Brian K. Cheng

    Inventor： Brian K. Cheng

    IPC: C08G73/02 ,  H01B1/12 ,  C08G73/00 ,  C08F283/00

    CPC classification number: H01B1/128 ,  C08G73/0266

    Abstract: An improved method for the synthesis of low molecular weight polyaniline provides for heating a para-haloaniline in the presence of a high-boiling organic solvent and a vanadium catalyst. A neutral polyaniline can be synthesized by removing hydrogen halide as it is produced.

    Abstract translation: 用于合成低分子量聚苯胺的改进方法提供了在高沸点有机溶剂和钒催化剂存在下加热对 - 卤代苯胺。 中性聚苯胺可以通过在其生产时除去卤化氢来合成。

    Process for Synthesizing Remifentanil
    8.
    发明申请
    Process for Synthesizing Remifentanil 审中-公开
    合成瑞芬太尼的方法

    公开(公告)号：US20080312448A1

    公开(公告)日：2008-12-18

    申请号：US12161171

    申请日：2007-01-08

    Applicant: Brian K. Cheng

    Inventor： Brian K. Cheng

    IPC: C07D211/06

    CPC classification number: C07D211/66

    Abstract: A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of synthetic opiate or opioid compounds. The process comprising reacting a 4-amino 4-carbamyl piperidine with a base in a closed reaction chamber at elevated temperature and pressure to form to intermediate which may be esterified with an alcohol, alkylated, and acylated to produce a synthetic opiate or opioid compound.

    Abstract translation: 一种合成瑞芬太尼或卡芬太尼的方法，以及用于制备合成阿片样物质或阿片样物质的中间体。 该方法包括使4-氨基-4-氨基甲酰哌啶与封闭的反应室中的碱在升高的温度和压力下反应形成中间体，其可用醇酯化，烷基化和酰化以产生合成的阿片样物质或阿片样物质。

    Process for Preparing Zolpidem Hemitartrate and Tartrate Polymorphs
    9.
    发明申请
    Process for Preparing Zolpidem Hemitartrate and Tartrate Polymorphs 审中-公开
    制备唑吡坦半酒石酸盐和酒石酸盐多晶型物的方法

    公开(公告)号：US20080293946A1

    公开(公告)日：2008-11-27

    申请号：US12067816

    申请日：2006-09-19

    Applicant: Brian K. Cheng

    Inventor： Brian K. Cheng

    IPC: C07D471/04

    CPC classification number: C07D471/04

    Abstract: A method for preparing a polymorph of a hemitartrate salt of a compound having the structure: comprising dissolving a free base form of the compound in a liquid medium comprising an alcohol and a tartrate derivative to form a solution comprising the compound, the alcohol, and the tartrate derivative; heating the solution to a temperature sufficient to dissolve the compound and the tartrate derivative; and cooling the solution to a temperature sufficient to precipitate the hemitartrate salt of the compound.

    Abstract translation: 制备具有以下结构的化合物的盐酸盐的多晶型物的方法：包括将游离碱形式的化合物溶解在包含醇和酒石酸盐衍生物的液体介质中以形成包含所述化合物，醇和 酒石酸衍生物 将溶液加热到足以溶解化合物和酒石酸衍生物的温度; 并将溶液冷却至足以沉淀该化合物的盐酸盐的温度。

    Ethanobicyclic amine derivatives for CNS disorders
    10.
    发明授权
    Ethanobicyclic amine derivatives for CNS disorders 失效
    用于CNS障碍的乙二醇胺衍生物

    公开(公告)号：US5215992A

    公开(公告)日：1993-06-01

    申请号：US801148

    申请日：1991-12-02

    Applicant: Nancy M. Gray ,  Brian K. Cheng

    Inventor： Nancy M. Gray ,  Brian K. Cheng

    IPC: C07D295/02 ,  C07D295/033

    CPC classification number: C07D295/033 ,  C07C2103/68 ,  C07C2103/72

    Abstract: Certain ethanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R.sup.3 and R.sup.4 may be taken together to form oxo;wherein each of R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, cycloalkylalkyl, alkoxyalkyl, phenalkyl and phenyl; wherein G within the nitrogen-containing cyclohetero moiety is selected from ##STR2## wherein R.sup.11 is selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, phenalkyl, alkoxyalkyl and hydroxyalkyl; wherein each of R.sup.12 and R.sup.13 is independently selected from hydrido, hydroxy, alkyl phenalkyl, phenyl, alkoxy, fluoroalkyl and fluoro; wherein m is one or two; wherein p is a number selected from zero through four, inclusive; wherein each of q and r is a number independently selected from one through three, inclusive with the proviso that sum of q and r is a number from three through six, inclusive; with the further proviso that the nitrogen-containing cyclohetero moiety must be attached at one position selected from R.sup.3, R.sup.4, ring-position two, and ring-position three; or the pharmaceutically-acceptable salts thereof.

    Abstract translation: 描述了某些乙酰胆碱胺化合物用于治疗中枢神经系统疾病如精神病，抽搐，肌张力障碍和脑缺血。 特别感兴趣的化合物具有式“IMAGE”，其中R 1，R 2，R 3，R 4，Y和Z各自独立地选自氢，羟基，烷基，环烷基，环烷基烷基，苯烷基，苯基，烷氧基，苯氧基，苯烷氧基，烷氧基烷基 ，卤素，卤代烷基和羟基烷基; 其中R 3和R 4可以一起形成氧代; 其中R 5，R 6，R 7，R 8，R 9和R 10各自独立地选自氢，烷基，环烷基，羟烷基，氟烷基，环烷基烷基，烷氧基烷基，苯烷基和苯基; 其中含氮环杂环部分中的G选自其中R 11选自氢，烷基，环烷基，环烷基烷基，苯基，苯烷基，烷氧基烷基和羟烷基; 其中R 12和R 13各自独立地选自氢，羟基，烷基苯基烷基，苯基，烷氧基，氟烷基和氟; 其中m是一个或两个; 其中p是选自0至4的数字，包括端值; 其中q和r各自独立地选自1至3个，其中q和r之和是3至6的数，包括3和6的数。 进一步的条件是含氮环杂环部分必须连接在选自R3，R4，环2位和环3位的一个位置上; 或其药学上可接受的盐。

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