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公开(公告)号：US09273028B2
公开(公告)日：2016-03-01
申请号：US13882449
申请日：2011-10-28
申请人： Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
发明人： Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC分类号： A01N43/00 , A61K31/00 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D473/34 , C07D513/04
CPC分类号： A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供可用作Tec家族激酶抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20120157443A1
公开(公告)日：2012-06-21
申请号：US13393192
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/553 , C07D487/04 , A61K31/519 , C07D401/04 , A61K31/506 , C07D473/34 , A61K31/52 , C07D417/14 , C07D413/12 , C07D401/14 , A61K31/55 , A61P37/06 , A61P29/00 , A61P35/00 , A61P35/02 , C12N9/99
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US08785440B2
公开(公告)日：2014-07-22
申请号：US13393192
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/535
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20130345192A1
公开(公告)日：2013-12-26
申请号：US13882449
申请日：2011-10-28
申请人： Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
发明人： Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC分类号： C07D401/12 , C07D513/04 , C07D473/34 , C07D471/04 , C07D487/04
CPC分类号： A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供可用作Tec家族激酶抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20120157442A1
公开(公告)日：2012-06-21
申请号：US13393191
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/553 , A61K31/519 , A61K31/5377 , C07D401/04 , A61K31/506 , A61P35/02 , A61K31/55 , C12N9/99 , A61P37/06 , A61P29/00 , A61P35/00 , C07D487/04 , C07D471/04
CPC分类号： C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US09029359B2
公开(公告)日：2015-05-12
申请号：US13393191
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号： C07D473/34 , C07D471/04 , C07D239/70 , C07D401/04 , C07D487/04
CPC分类号： C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US07378525B2
公开(公告)日：2008-05-27
申请号：US10744585
申请日：2003-12-23
申请人： Bing Guan , Charles Minor , Mingshi Dai , Shomir Ghosh , Tracy J. Jenkins , Gang Li , Douglas F. Burdi , Robert A. Bennett
发明人： Bing Guan , Charles Minor , Mingshi Dai , Shomir Ghosh , Tracy J. Jenkins , Gang Li , Douglas F. Burdi , Robert A. Bennett
IPC分类号： C07D211/06 , C07D211/68
CPC分类号： C07D401/12 , C07C311/46 , C07C311/47 , C07C335/16 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D207/14 , C07D211/28 , C07D211/58 , C07D405/12 , C07D413/12
摘要： Disclosed are CCR8 inhibitors represented by Structural Formulas (I): The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.
摘要翻译： 公开了由结构式（I）表示的CCR8抑制剂：本文描述了结构式（I）中的变量。 还公开了通过向受试者施用所公开的CCR8抑制剂之一来治疗CCR8介导的病症，特别是哮喘的受试者的方法。
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公开(公告)号：US07329755B2
公开(公告)日：2008-02-12
申请号：US10744236
申请日：2003-12-23
申请人： Mingshi Dai , Tracy J. Jenkins , Bing Guan , Shomir Ghosh , Charles Minor
发明人： Mingshi Dai , Tracy J. Jenkins , Bing Guan , Shomir Ghosh , Charles Minor
IPC分类号： C07D211/68 , C07D211/06
CPC分类号： C07D213/42 , C07C311/37 , C07C311/46 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D207/14 , C07D207/27 , C07D209/48 , C07D211/28 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/76 , C07D213/81 , C07D295/13 , C07D295/26 , C07D307/68 , C07D309/08 , C07D309/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D407/12 , C07D413/04 , C07D413/12 , C07D451/04
摘要： Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.
摘要翻译： 公开了由结构式（I）表示的CCR8抑制剂：还公开了包含药学上可接受的载体或稀释剂和由结构式（I）表示的CCR8抑制剂的药物组合物。 还公开了通过向受试者施用CCR8抑制剂来治疗受试者的炎症性疾病的方法。
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9.发明授权公开(公告)号：US07491827B2
公开(公告)日：2009-02-17
申请号：US10891362
申请日：2004-07-14
申请人： Mingshi Dai , Bing Guan , Robert A. Bennett , Douglas F. Burdi , Shomir Ghosh , Gang Li , Charles Minor , Tracy J. Jenkins
发明人： Mingshi Dai , Bing Guan , Robert A. Bennett , Douglas F. Burdi , Shomir Ghosh , Gang Li , Charles Minor , Tracy J. Jenkins
IPC分类号： C07D211/06 , C07D215/38 , C07D413/00 , C07D239/02
CPC分类号： C07C311/46 , C07C311/37 , C07C311/47 , C07C335/16 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/48 , C07D211/28 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/42 , C07D213/76 , C07D213/81 , C07D295/12 , C07D295/13 , C07D295/26 , C07D307/54 , C07D307/68 , C07D309/08 , C07D309/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D407/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D451/04
摘要： The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
摘要翻译： 本发明提供通式I化合物或其药学上可接受的盐，其中R 1，X，Z，R 2，X 1，Ar，n，R 3和R 4通常在本文中定义。 本发明的化合物是CCR8的抑制剂，因此可用于治疗各种炎性和过敏性疾病。
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公开(公告)号：US20090275556A1
公开(公告)日：2009-11-05
申请号：US12229818
申请日：2008-08-27
申请人： Mingshi Dai , Bing Guan , Roert A. Bennett , Douglas F. Burdi , Shomir Ghosh , Gang Li , Charles Minor , Tracy J. Jenkins
发明人： Mingshi Dai , Bing Guan , Roert A. Bennett , Douglas F. Burdi , Shomir Ghosh , Gang Li , Charles Minor , Tracy J. Jenkins
IPC分类号： A61K31/397 , C07C311/14 , A61K31/18 , C07D209/04 , A61K31/4035 , C07D295/00 , A61K31/495 , C07D213/02 , A61K31/44 , C07D211/06 , A61P29/00 , A61K31/4545 , C07D413/02 , A61K31/5377 , C07D239/24 , A61K31/506 , C07D401/02 , A61K31/496
CPC分类号： C07C311/46 , C07C311/37 , C07C311/47 , C07C335/16 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/48 , C07D211/28 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/42 , C07D213/76 , C07D213/81 , C07D295/12 , C07D295/13 , C07D295/26 , C07D307/54 , C07D307/68 , C07D309/08 , C07D309/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D407/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D451/04
摘要： The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
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