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公开(公告)号：US20120157442A1
公开(公告)日：2012-06-21
申请号：US13393191
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/553 , A61K31/519 , A61K31/5377 , C07D401/04 , A61K31/506 , A61P35/02 , A61K31/55 , C12N9/99 , A61P37/06 , A61P29/00 , A61P35/00 , C07D487/04 , C07D471/04
CPC分类号： C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US09029359B2
公开(公告)日：2015-05-12
申请号：US13393191
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC分类号： C07D473/34 , C07D471/04 , C07D239/70 , C07D401/04 , C07D487/04
CPC分类号： C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20120157443A1
公开(公告)日：2012-06-21
申请号：US13393192
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/553 , C07D487/04 , A61K31/519 , C07D401/04 , A61K31/506 , C07D473/34 , A61K31/52 , C07D417/14 , C07D413/12 , C07D401/14 , A61K31/55 , A61P37/06 , A61P29/00 , A61P35/00 , A61P35/02 , C12N9/99
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US08785440B2
公开(公告)日：2014-07-22
申请号：US13393192
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/535
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US07968536B2
公开(公告)日：2011-06-28
申请号：US12164905
申请日：2008-06-30
申请人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/505
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20090005359A1
公开(公告)日：2009-01-01
申请号：US12164905
申请日：2008-06-30
申请人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Jennifer Cossrow , Bing Guan , Alexey Ishchenko , John Howard Jones , Gnanasambandam Kumaravel , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： A61K31/55 , C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/519
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20120040951A1
公开(公告)日：2012-02-16
申请号：US13142603
申请日：2009-12-30
申请人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
发明人： Claudio Chuaqui , Jennifer Cossrow , James Dowling , Bing Guan , Michael Hoemann , Alexey Ishchenko , John Howard Jones , Lori Kabigting , Gnanasambandam Kumaravel , Hairuo Peng , Noel Powell , Brian Raimundo , Hiroko Tanaka , Kurt van Vloten , Jeffrey Vessels , Zhili Xin
IPC分类号： A61K31/437 , A61K31/5377 , C07D417/14 , A61P35/00 , A61P9/00 , A61P25/28 , A61P37/00 , A61P37/06 , A61P29/00 , A61P31/12 , A61P19/08 , A61P1/16 , A61P7/00 , A61P3/10 , C12N9/99 , C07D471/04
CPC分类号： C07D261/08 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的式（I）化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US08293752B2
公开(公告)日：2012-10-23
申请号：US12164762
申请日：2008-06-30
申请人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： A61K31/535 , A61K31/52 , C07D239/42 , C07D413/14 , C07D401/14
CPC分类号： C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20090036419A1
公开(公告)日：2009-02-05
申请号：US12164762
申请日：2008-06-30
申请人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
发明人： Weirong Chen , Jennifer Cossrow , Lloyd Franklin , Bing Guan , John Howard Jones , Gnanasambandam Kumaravel , Benjamin Lane , Adam Littke , Alexey Lugovskoy , Hairuo Peng , Noel Powell , Brian C. Raimundo , Hiroko Tanaka , Jeffrey Vessels , Thomas Wynn , Zhili Xin
IPC分类号： A61K31/397 , C07D239/24 , A61K31/505 , C07D295/00 , C07D473/00 , C12N9/99 , A61P9/00 , A61P37/02 , A61P31/12 , A61P19/08 , A61P29/00 , A61P25/00 , A61P35/00 , A61K31/52 , A61K31/5377 , A61K31/496 , A61K31/502
CPC分类号： C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供了可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。
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公开(公告)号：US20120208819A1
公开(公告)日：2012-08-16
申请号：US13499835
申请日：2010-10-05
申请人： Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
发明人： Joseph Arndt , Timothy Chan , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Daniel Scott , Lihong Sun , Jermaine Thomas , Kurt van Vloten , Deping Wang , Lei Zhang , Daniel Erlanson
IPC分类号： A61K31/53 , C07D401/14 , C07D409/14 , A61P35/00 , A61K31/444 , A61K31/519 , A61K31/4439 , A61K31/517 , C07D471/04 , C07D401/12
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
摘要翻译： 本发明提供了可用作PDK1抑制剂的化合物。 本发明还提供了其组合物，以及治疗PDK1介导的疾病的方法。
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