-
1.发明授权Variants of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase 有权编码甘油醛-3-磷酸脱氢酶的间隙基因的启动子的变体公开(公告)号：US09074229B2
公开(公告)日：2015-07-07
申请号：US14607177
申请日：2015-01-28
申请人： Alexander Reth , Brigitte Bathe , Stephan Hans , Wilfried Claes
发明人： Alexander Reth , Brigitte Bathe , Stephan Hans , Wilfried Claes
摘要： The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
摘要翻译： 本发明涉及具有启动子活性的分离的多核苷酸，编码甘油醛-3-磷酸脱氢酶的间隙基因的启动子的变体; 以及产生和/或分泌精细化学物质的微生物，所述微生物包括具有启动子活性的分离的多核苷酸，其使各种基因与特定的起始菌株相比过表达; 以及使用微生物制备精细化学品的方法。
-
2.发明授权Process for the fermentative preparation of organic chemical compounds using Coryneform bacteria in which the sugR gene is present in attenuated form 有权使用棒状细菌发酵制备有机化合物的方法，其中sugR基因以减毒形式存在公开(公告)号：US08592177B2
公开(公告)日：2013-11-26
申请号：US13355531
申请日：2012-01-21
申请人： Brigitte Bathe , Georg Thierbach , Volker Wendisch , Verena Engels , Bernhard Eikmanns , Bastian Blombach
发明人： Brigitte Bathe , Georg Thierbach , Volker Wendisch , Verena Engels , Bernhard Eikmanns , Bastian Blombach
摘要： The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
摘要翻译： 本发明涉及分泌有机化合物的重组棒状细菌，其中编码具有SugR调节剂活性的多肽的sugR基因已被减弱。 本发明还涉及使用该细菌用于有机化合物的发酵制剂的方法。
-
公开(公告)号：US08293514B2
公开(公告)日：2012-10-23
申请号：US12781230
申请日：2010-05-17
IPC分类号： C12N9/12
CPC分类号： C12P13/08 , A23L33/135 , A23L33/175 , C12N9/1235 , C12P13/04
摘要： An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
摘要翻译： 棒状细菌的分离突变体，其包含编码具有GTP-焦磷酸激酶活性的多肽的基因，其中所述多肽包含氨基酸序列，其中除了L-脯氨酸以外的蛋白原氨基酸之一存在于位置38或相应的 或相当的地位。 此外，描述了编码具有GTP焦磷酸激酶酶活性的多肽的分离的多核苷酸，包含分离的多核苷酸的载体，包含载体的重组微生物和制备重组棒状杆菌型细菌的方法。 还描述了过表达GTP焦磷酸激酶的方法，制备L-氨基酸的方法，包含L-赖氨酸的L-赖氨酸和包含L-色氨酸的饲料。
-
公开(公告)号：US20090311758A1
公开(公告)日：2009-12-17
申请号：US12468512
申请日：2009-05-19
摘要： A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
摘要翻译： 提供了使用其中AmtR调节剂已被减毒的棒状细菌制备L-氨基酸的方法。 公开了对应于或具有衰减的AmtR调节剂的重组细菌，多核苷酸和载体。
-
公开(公告)号：US07585650B2
公开(公告)日：2009-09-08
申请号：US11790063
申请日：2007-04-23
CPC分类号： C12P13/08 , C07K14/34 , C12P13/227
摘要： The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
-
公开(公告)号：US20080131927A1
公开(公告)日：2008-06-05
申请号：US11383253
申请日：2006-05-15
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的OpcA亚基变体的棒状杆菌细菌的opcA基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
-
公开(公告)号：US20080131903A1
公开(公告)日：2008-06-05
申请号：US12016728
申请日：2008-01-18
CPC分类号： C12P13/22 , C12N9/0006 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
摘要翻译： 本发明涉及编码6-磷酸葡萄糖酸脱氢酶的棒状细菌的gnd基因的突变体和等位基因，其含有第329位或氨基酸序列与L-缬氨酸以外的任何氨基酸的可比较位置，以及用于生产 氨基酸，优选L-赖氨酸和L-色氨酸，通过使用含有这些等位基因的细菌进行发酵。
-
8.发明授权Coryneform bacteria with altered glucokinase activity in the production of L-lysine 有权在L-赖氨酸生产中具有改变的葡萄糖激酶活性的棒状细菌公开(公告)号：US07306932B2
公开(公告)日：2007-12-11
申请号：US10498889
申请日：2002-11-07
申请人： Brigitte Bathe , Stephan Hans , Caroline Reynen
发明人： Brigitte Bathe , Stephan Hans , Caroline Reynen
CPC分类号： C12N9/1205 , C12P13/08
摘要： The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles.
摘要翻译： 本发明涉及编码葡萄糖激酶的棒状细菌的glk基因的等位基因，以及使用含有这种等位基因的细菌通过发酵生产L-赖氨酸的方法。
-
公开(公告)号：US20070259408A1
公开(公告)日：2007-11-08
申请号：US11783061
申请日：2007-04-05
申请人： Brigitte Bathe , Wilfried Claes , Stephan Hans
发明人： Brigitte Bathe , Wilfried Claes , Stephan Hans
摘要： The present invention is directed to bacteria which contain a lysCFBR that encodes a feedback resistant aspartokinase enzyme and whose expression is under the control of a gleceraldehyde-3-phosphate dehydrogenase (gap) promoter. The bacteria may be used in the fermentative production of L-amino acids, especially, L-lysine.
摘要翻译： 本发明涉及含有编码反馈性天冬氨酸激酶并且其表达在格隆醛-3-磷酸脱氢酶（间隙）启动子控制下的lysCFBR的细菌。 细菌可用于发酵生产L-氨基酸，特别是L-赖氨酸。
-
公开(公告)号：US20070141680A1
公开(公告)日：2007-06-21
申请号：US11705714
申请日：2007-02-14
CPC分类号： C12P13/04 , C12N9/0006
摘要： The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
-
-
-
-
-
-
-
-
-
搜索结果
120 条记录 (耗时 0.032 秒)
