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公开(公告)号：US20100196959A1
公开(公告)日：2010-08-05
申请号：US12696449
申请日：2010-01-29
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的OpcA亚基变体的棒状杆菌细菌的opcA基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US07700313B2
公开(公告)日：2010-04-20
申请号：US11383253
申请日：2006-05-15
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的OpcA亚基变体的棒状杆菌细菌的opcA基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US08153404B2
公开(公告)日：2012-04-10
申请号：US12458966
申请日：2009-07-28
CPC分类号： C12P13/08 , C07K14/34 , C12P13/227
摘要： The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的Zwf亚基的变体的棒状细菌的zwf基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US07563602B2
公开(公告)日：2009-07-21
申请号：US12016728
申请日：2008-01-18
CPC分类号： C12P13/22 , C12N9/0006 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
摘要翻译： 本发明涉及编码6-磷酸葡萄糖酸脱氢酶的棒状细菌的gnd基因的突变体和等位基因，其含有第329位或氨基酸序列与L-缬氨酸以外的任何氨基酸的可比较位置，以及用于生产 氨基酸，优选L-赖氨酸和L-色氨酸，通过使用含有这些等位基因的细菌进行发酵。
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公开(公告)号：US20070224666A1
公开(公告)日：2007-09-27
申请号：US11790063
申请日：2007-04-23
CPC分类号： C12P13/08 , C07K14/34 , C12P13/227
摘要： The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的Zwf亚基变体的棒状细菌的zwf基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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公开(公告)号：US20060246554A1
公开(公告)日：2006-11-02
申请号：US11227138
申请日：2005-09-16
CPC分类号： C12P13/22 , C12N9/0006 , C12P13/08 , C12P13/227
摘要： The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and L-tryptophan, by fermentation using bacteria that contain these alleles.
摘要翻译： 本发明涉及编码6-磷酸葡萄糖酸脱氢酶的棒状细菌的gnd基因的突变体和等位基因，其含有第329位或氨基酸序列与L-缬氨酸以外的任何氨基酸的可比较位置，以及用于生产 氨基酸，优选L-赖氨酸和L-色氨酸，通过使用含有这些等位基因的细菌进行发酵。
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公开(公告)号：US07915394B2
公开(公告)日：2011-03-29
申请号：US12696449
申请日：2010-01-29
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/227
摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的OpcA亚基变体的棒状杆菌细菌的opcA基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。
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8.发明授权公开(公告)号：US07618798B2
公开(公告)日：2009-11-17
申请号：US11705714
申请日：2007-02-14
CPC分类号： C12P13/04 , C12N9/0006
摘要： The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
摘要翻译： 本发明涉及棒状细菌mqo基因的突变体和等位基因，其编码苹果酸醌氧化还原酶，其在氨基酸序列中含有111位的L-丝氨酸或氨基酸序列的相当位置的任何氨基酸，以及用于发酵制备氨基酸的方法 酸，优选L-赖氨酸，L-色氨酸和L-脯氨酸，使用包含这些等位基因的细菌。
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公开(公告)号：US07214526B2
公开(公告)日：2007-05-08
申请号：US11333718
申请日：2006-01-18
CPC分类号： C12P13/04 , C12N9/0006
摘要： The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and L-proline, using bacteria which comprise these alleles.
摘要翻译： 本发明涉及棒状细菌mqo基因的突变体和等位基因，其编码苹果酸醌氧化还原酶，其在氨基酸序列中含有111位的L-丝氨酸或氨基酸序列的相当位置的任何氨基酸，以及用于发酵制备氨基酸的方法 酸，优选L-赖氨酸，L-色氨酸和L-脯氨酸，使用包含这些等位基因的细菌。
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10.发明申请Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 审中-公开编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列公开(公告)号：US20050233424A1
公开(公告)日：2005-10-20
申请号：US10898345
申请日：2004-07-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： A23K1/00 , A23K1/16 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/88 , C12P13/08 , C12P13/12 , C07H21/04 , C12N15/74
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译： 来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法 使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针 以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。
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