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    Nucleotide sequences encoding histidine kinase from corynebacterium glutamicum
    1.
    发明授权
    Nucleotide sequences encoding histidine kinase from corynebacterium glutamicum 失效
    编码来自谷氨酸棒杆菌的组氨酸激酶的核苷酸序列

    公开(公告)号：US06746854B2

    公开(公告)日：2004-06-08

    申请号：US09824551

    申请日：2001-08-01

    申请人： Brigitte Bathe ,  Caroline Kreutzer ,  Achim Marx ,  Walter Pfefferle

    发明人： Brigitte Bathe ,  Caroline Kreutzer ,  Achim Marx ,  Walter Pfefferle

    IPC分类号： C12P1308

    CPC分类号： C12N9/1223 ,  C12P13/08

    摘要： This invention relates to novel polynucleotide sequences encoding the histidine kinase luminescence expression sensor (luxS) gene from Corynebaclerium glutamicum, probes to the novel polynucleotide sequences encoding the luxS gene, vector and host cells containing the novel luxS polynucleotide sequences, the encoded Lux S polypeptide, and a process for the fermentative preparation of amino acids using bacteria which the luxS gene is attenuated.

    摘要翻译： 本发明涉及编码来自谷氨酸棒杆菌的组氨酸激酶发光表达传感器（luxS）基因的新型多核苷酸序列，探针编码luxS基因的新型多核苷酸序列，含有新型luxS多核苷酸序列的载体和宿主细胞，编码的Lux S多肽， 以及使用luxS基因减毒的细菌发酵制备氨基酸的方法。

    Nucleotide sequences which code for the rpsL gene
    3.
    发明授权
    Nucleotide sequences which code for the rpsL gene 有权
    编码rpsL基因的核苷酸序列

    公开(公告)号：US06939695B2

    公开(公告)日：2005-09-06

    申请号：US10075460

    申请日：2002-02-15

    申请人： Bettina Moeckel ,  Brigitte Bathe ,  Stefan Hans ,  Caroline Kreutzer ,  Thomas Hermann ,  Walter Pfefferle ,  Michael Binder

    发明人： Bettina Moeckel ,  Brigitte Bathe ,  Stefan Hans ,  Caroline Kreutzer ,  Thomas Hermann ,  Walter Pfefferle ,  Michael Binder

    IPC分类号： C07K14/34 ,  C12N15/31 ,  C12P13/04 ,  C07H21/04

    CPC分类号： C07K14/34

    摘要： An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸，b） 编码多肽的多核苷酸，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸， 和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少存在rpsL基因 增强形式，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

    Nucleotide sequences which code for the zwa1 gene
    6.
    发明授权
    Nucleotide sequences which code for the zwa1 gene 失效
    编码zwa1基因的核苷酸序列

    公开(公告)号：US06632644B2

    公开(公告)日：2003-10-14

    申请号：US09731909

    申请日：2000-12-08

    申请人： Bettina Möckel ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    发明人： Bettina Möckel ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    IPC分类号： C12P1308

    CPC分类号： C07K14/34 ,  C12N9/00 ,  C12P13/08

    摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO 2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.

    摘要翻译： 本发明涉及一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码多肽的多核苷酸的程度相同的多核苷酸，所述多核苷酸包含氨基酸序列 b）编码多肽的多核苷酸，其包含与SEQ ID NO 2的氨基酸序列至少70％的程度相同的氨基酸序列，c） 与a）和b）和d）多核苷酸互补的多核苷酸，其包含a），b）或c），/或PTEXT的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及发酵 在使用棒状细菌中扩增zwa1基因的L-氨基酸的制备

    Nucleotide sequences coding for the citE gene
    7.
    发明授权
    Nucleotide sequences coding for the citE gene 失效
    编码citE基因的核苷酸序列

    公开(公告)号：US07129066B2

    公开(公告)日：2006-10-31

    申请号：US10375355

    申请日：2003-02-28

    申请人： Mike Farwick ,  Klaus Huthmacher ,  Achim Marx ,  Brigitte Bathe ,  Walter Pfefferle

    发明人： Mike Farwick ,  Klaus Huthmacher ,  Achim Marx ,  Brigitte Bathe ,  Walter Pfefferle

    IPC分类号： C12P13/08 ,  C12P13/04 ,  C12N9/88 ,  C07H21/04

    CPC分类号： C12Y401/03006 ,  C12N9/88

    摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2, b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c), and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.

    摘要翻译： 本发明涉及含有多核苷酸序列的多核苷酸序列，该多核苷酸序列选自a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码 对于含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少含有 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及通过发酵使用其中至少有citE基因以减毒形式存在的棒状细菌产生L-氨基酸的方法， 使用含有本发明序列的多核苷酸作为杂交探针。

    Polynucleotide sequences which encode the zwa1 gene
    8.
    发明授权
    Polynucleotide sequences which encode the zwa1 gene 失效
    编码zwa1基因的多核苷酸序列

    公开(公告)号：US07074607B2

    公开(公告)日：2006-07-11

    申请号：US10640263

    申请日：2003-08-14

    申请人： Bettina Möckel ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    发明人： Bettina Möckel ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    IPC分类号： C12P1/00 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C07H21/02

    CPC分类号： C07K14/34 ,  C12N9/00 ,  C12P13/08

    摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO 2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.

    摘要翻译： 本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码包含SEQ ID NO：2的氨基酸序列的多肽的至少70％的多核苷酸程度相同 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％的程度相同的氨基酸序列）与a）和b的多核苷酸互补的多核苷酸 ）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。

    Process for the preparation of l-amino acids
    10.
    发明授权
    Process for the preparation of l-amino acids 失效
    制备1-氨基酸的方法

    公开(公告)号：US07262036B2

    公开(公告)日：2007-08-28

    申请号：US11419529

    申请日：2006-05-22

    申请人： Bettina Hädrich ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    发明人： Bettina Hädrich ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    IPC分类号： C12P13/08 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C07H21/02

    CPC分类号： C07K14/34 ,  C12N9/00 ,  C12P13/08

    摘要： Disclosed herein is an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO:2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO:2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.

    摘要翻译： 本文公开了一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID NO：2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％相同程度的氨基酸序列c）与a）和 b）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。