-
公开(公告)号：US07772178B2
公开(公告)日：2010-08-10
申请号：US11444078
申请日：2006-05-31
申请人： Bruce A. Malcolm , Prudence K. Bradley , Anastasia Pavlovsky , Wing-Kee Philip Cho , Zhihui Qiu
发明人： Bruce A. Malcolm , Prudence K. Bradley , Anastasia Pavlovsky , Wing-Kee Philip Cho , Zhihui Qiu
IPC分类号： A61K38/12
CPC分类号： A61K38/12 , A61K31/454 , A61K31/4709 , A61K38/05 , A61K38/06 , A61K38/08 , A61K47/10 , A61K2300/00
摘要： Pharmaceutical formulations containing at least one compound of Formulae I-XXVI herein and at least one surfactant. Pharmaceutically acceptable carriers and excipients may also be included in the formulations. The formulations of the present invention are suited for use in single unit dosages.
摘要翻译： 含有至少一种本文的式I-XXVI化合物和至少一种表面活性剂的药物制剂。 药学上可接受的载体和赋形剂也可以包括在制剂中。 本发明的制剂适用于单一单位剂量。
-
公开(公告)号：US20090209483A1
公开(公告)日：2009-08-20
申请号：US12412967
申请日：2009-03-27
申请人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
IPC分类号： A61K31/7068
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
-
3.发明授权Single-chain recombinant complexes of hepatitis C virus NS3 protease and NS4A cofactor peptide 失效丙型肝炎病毒NS3蛋白酶和NS4A辅因子单链重组复合物公开(公告)号：US06653127B1
公开(公告)日：2003-11-25
申请号：US09684881
申请日：2000-10-06
IPC分类号： C12N1574
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/506 , C12N9/90 , C12N2770/24222
摘要： Covalent HCV NS4A-NS3 complexes comprising the central hydrophobic domain of native HCV NS4A peptide, a linker, and the HCV NS3 serine protease domain, wherein the hydrophobic domain of native HCV NS4A peptide is tethered by the linker to the amino terminus of the HCV NS3 protease domain.
摘要翻译： 共价HCV NS4A-NS3复合物，其包含天然HCV NS4A肽的中枢疏水结构域，接头和HCV NS3丝氨酸蛋白酶结构域，其中天然HCV NS4A肽的疏水结构域被连接体连接到HCV NS3的氨基末端 蛋白酶结构域。
-
公开(公告)号：US20110033422A1
公开(公告)日：2011-02-10
申请号：US12906651
申请日：2010-10-18
申请人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
IPC分类号： A61K38/21 , A61K31/7068 , A61P31/12
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
-
公开(公告)号：US07569391B2
公开(公告)日：2009-08-04
申请号：US11634737
申请日：2006-12-06
CPC分类号： C12N9/6421 , C07K2299/00
摘要： The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding human BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.
摘要翻译： 本申请涉及用于生长未络合和复合形式的β-分泌酶（BACE）多肽的晶体的方法。 本申请还涉及未结合的BACE的晶体形式和由晶体确定的BACE的三维结构。 此外，本申请涉及BACE的结晶形式用于鉴定与BACE结合并优选抑制BACE的酶活性的配体，优选抑制剂（拮抗剂）。 此外，本申请涉及编码人BACE多肽的核酸序列和与以前的方法相比制备BACE的方法，导致更有效的结晶。
-
公开(公告)号：US07816339B2
公开(公告)日：2010-10-19
申请号：US12412967
申请日：2009-03-27
申请人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
发明人： Bruce A. Malcolm , Robert Palermo , Xiao Tong , Boris Feld , Hung Le
CPC分类号： A61K31/7072 , A61K38/212 , A61K2300/00
摘要： The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
摘要翻译： 本发明提供了在宿主中通过属于黄病毒科的病毒如HCV的感染的方法，其包括向宿主施用Ara-C同源物。
-
7.发明申请REFOLDED RECOMBINANT ALPHA SECRETASE CRYSTALS AND METHODS FOR PREPARING AND USING THE SAME 有权重建的重组ALPHA分泌物晶体及其制备和使用方法公开(公告)号：US20100203616A1
公开(公告)日：2010-08-12
申请号：US12434897
申请日：2009-05-04
IPC分类号： C12N9/50
CPC分类号： C12N9/6421 , C07K2299/00
摘要： The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.
摘要翻译： 本申请涉及用于生长未络合和复合形式的分泌型（BACE）多肽的晶体的方法。 本申请还涉及未结合的BACE的晶体形式和由晶体确定的BACE的三维结构。 此外，本申请涉及BACE的结晶形式用于鉴定与BACE结合并优选抑制BACE的酶活性的配体，优选抑制剂（拮抗剂）。 此外，本申请涉及编码BACE多肽的核酸序列和与以前的方法相比制备BACE的方法，导致更有效的结晶。
-
8.发明授权Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus 失效二芳基肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US06911428B2
公开(公告)日：2005-06-28
申请号：US10013071
申请日：2001-12-10
申请人： Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
发明人： Zhaoning Zhu , Zhong-Yue Sun , Srikanth Venkatraman , F. George Njoroge , Ashok Arasappan , Bruce A. Malcolm , Viyyoor M. Girijavallabhan , Raymond G. Lovey , Kevin X. Chen
IPC分类号： C12N9/99 , A61K31/7042 , A61K38/00 , A61K38/21 , A61K45/00 , A61P31/12 , A61P31/14 , A61P43/00 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/00 , C07K14/81 , A61K38/17 , A61K31/33 , C07K7/64
CPC分类号： C07K5/0202 , A61K38/00 , C07K14/811
摘要： The present invention is directed to certain diaryl amide compounds as NS3-Serine protease inhibitors of hepatitis C virus. A particularly preferred compound is of the formula:
摘要翻译： 本发明涉及某些二芳基酰胺化合物作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂。 特别优选的化合物具有下式：
-
9.发明授权Single-chain recombinant complexes of hepatitis C virus NS3 protease and NS4A cofactor peptide 有权丙型肝炎病毒NS3蛋白酶和NS4A辅因子单链重组复合物公开(公告)号：US06211338B1
公开(公告)日：2001-04-03
申请号：US09198723
申请日：1998-11-24
IPC分类号： C07K1402
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/506 , C12N9/90 , C12N2770/24222
摘要： Covalent HCV NS4A-NS3 complexes comprising the central hydrophobic domain of native HCV NS4A peptide, a linker, and the HCV NS3 serine protease domain, wherein the hydrophobic domain of native HCV NS4A peptide is tethered by the linker to the amino terminus of the HCV NS3 protease domain.
摘要翻译： 共价HCV NS4A-NS3复合物，其包含天然HCV NS4A肽的中枢疏水结构域，接头和HCV NS3丝氨酸蛋白酶结构域，其中天然HCV NS4A肽的疏水结构域被连接体连接到HCV NS3的氨基末端 蛋白酶结构域。
-
10.发明授权Refolded recombinant β-secretase crystals and methods for preparing and using the same 有权重折叠重组和分泌酶晶体及其制备和使用方法公开(公告)号：US08063185B2
公开(公告)日：2011-11-22
申请号：US12434897
申请日：2009-05-04
IPC分类号： C12N1/12
CPC分类号： C12N9/6421 , C07K2299/00
摘要： The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the use of crystalline forms of BACE to identify ligands, preferably inhibitors (antagonists), which bind to, and preferably inhibit the enzymatic activity of, BACE. Furthermore, the present application relates to nucleic acid sequences encoding BACE polypeptide, and methods for making BACE in greater quantity than prior methods, resulting in more effective crystallization.
摘要翻译： 本申请涉及用于生长未络合和复合形式的分泌型（BACE）多肽的晶体的方法。 本申请还涉及未结合的BACE的晶体形式和由晶体确定的BACE的三维结构。 此外，本申请涉及BACE的结晶形式用于鉴定与BACE结合并优选抑制BACE的酶活性的配体，优选抑制剂（拮抗剂）。 此外，本申请涉及编码BACE多肽的核酸序列和与以前的方法相比制备BACE的方法，导致更有效的结晶。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.042 秒)
