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公开(公告)号：US5866723A
公开(公告)日：1999-02-02
申请号：US671420
申请日：1996-06-27
IPC分类号： C07B61/00 , C07C45/45 , C07C45/46 , C07C45/51 , C07C47/55 , C07C49/697 , C07C49/80 , C07C49/807 , C07C51/305 , C07C63/70 , C07C65/21 , C07C65/32
CPC分类号： C07C65/21 , C07C45/455 , C07C45/46 , C07C45/513 , C07C47/55 , C07C49/80 , C07C49/807 , C07C51/235 , C07C63/70
摘要： The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
摘要翻译： 本发明涉及新的4-卤代-2-氟-5-烷基苯甲酰基化合物及其制备方法。 这些化合物可用于制备农药和药物，特别是作为活性类芳基 - 卤代烷基吡唑和芳基烷基磺酰吡唑除草剂的中间体。
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公开(公告)号：US5600008A
公开(公告)日：1997-02-04
申请号：US403037
申请日：1995-03-13
CPC分类号： C07C45/292 , C07C45/455 , C07C45/513
摘要： The present invention relates to novel 4-halo-2-fluoro-5-alkoxybenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of arylhaloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
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公开(公告)号：US5532416A
公开(公告)日：1996-07-02
申请号：US277725
申请日：1994-07-20
IPC分类号： C07B61/00 , C07C45/45 , C07C45/46 , C07C45/51 , C07C47/55 , C07C49/697 , C07C49/80 , C07C49/807 , C07C51/305 , C07C63/70 , C07C65/21 , C07C65/32
CPC分类号： C07C65/21 , C07C45/455 , C07C45/46 , C07C45/513 , C07C47/55 , C07C49/80 , C07C49/807 , C07C51/235 , C07C63/70
摘要： The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
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公开(公告)号：US5654490A
公开(公告)日：1997-08-05
申请号：US432355
申请日：1995-05-01
IPC分类号： C07B61/00 , C07C45/45 , C07C45/46 , C07C45/51 , C07C47/55 , C07C49/697 , C07C49/80 , C07C49/807 , C07C51/305 , C07C63/70 , C07C65/21 , C07C65/32 , C07C45/43
CPC分类号： C07C65/21 , C07C45/455 , C07C45/46 , C07C45/513 , C07C47/55 , C07C49/80 , C07C49/807 , C07C51/235 , C07C63/70
摘要： The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
摘要翻译： 本发明涉及新的4-卤代-2-氟-5-烷基苯甲酰基化合物及其制备方法。 这些化合物可用于制备农药和药物，特别是作为活性类芳基 - 卤代烷基吡唑和芳基烷基磺酰吡唑除草剂的中间体。
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公开(公告)号：US5600016A
公开(公告)日：1997-02-04
申请号：US403038
申请日：1995-03-13
CPC分类号： C07C45/292 , C07C45/455 , C07C45/513
摘要： The present invention relates to novel 4-halo-2-fluoro-5-alkoxybenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of arylhaloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
摘要翻译： 本发明涉及新的4-卤代-2-氟-5-烷氧基苯甲酰基化合物及其制备方法。 这些化合物可用于制备农药和药物，特别是作为活性类芳基卤代烷基吡唑和芳基烷基磺酰吡唑除草剂的中间体。
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公开(公告)号：US20080146569A1
公开(公告)日：2008-06-19
申请号：US11954799
申请日：2007-12-12
申请人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
发明人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
IPC分类号： A61K31/5377 , A61K31/4545 , A61P11/06 , C07D211/30 , C07D413/14 , C07D419/14 , C07D239/42 , A61P37/08 , A61K31/506
CPC分类号： C07D401/12 , C07D213/82 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。
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公开(公告)号：US5986104A
公开(公告)日：1999-11-16
申请号：US190808
申请日：1998-11-12
IPC分类号： C07C45/45 , C07C65/32 , C07C69/738 , C07D231/12 , C07D231/16 , C07D231/18 , C07D231/10
CPC分类号： C07D231/12 , C07C45/455 , C07C65/32 , C07C69/738 , C07D231/16 , C07D231/18
摘要： Processes for preparing substituted 3-aryl-5-haloalkyl-pyrazoles and, specifically, for preparing C.sub.1-5 alkyl esters of 5-[1-(C.sub.1-5 alkyl)-4-halo-5-(C.sub.1-3 haloalkyl)-1H-pyrazole-3-yl]-2,4-dihalo-benzoic acids such as isopropyl 5-[4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-yl]-2-chloro-4-fluorobenzoate, are presented. The described processes include novel approaches for forming phenyldiketones, forming and alkylating pyrazoles, brominating heterocyclic compounds, oxidizing alkyl-substituted benzene compounds, and esterifying carboxylic acids. These processes may be combined to prepare 3-aryl-5-haloalkyl pyrazoles, or alternatively, used in subcombinations or individually to prepare intermediates or other useful compounds.
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公开(公告)号：US5281571A
公开(公告)日：1994-01-25
申请号：US763762
申请日：1991-09-25
申请人： Scott S. Woodard , Bruce C. Hamper , Kurt Moedritzer , Michael D. Rogers , Deborah A. Mischke , Gerard A. Dutra
发明人： Scott S. Woodard , Bruce C. Hamper , Kurt Moedritzer , Michael D. Rogers , Deborah A. Mischke , Gerard A. Dutra
IPC分类号： A01N43/56 , A01N43/78 , A01P7/04 , C07C45/29 , C07C45/45 , C07C49/80 , C07C49/835 , C07D231/12 , C07D231/16 , C07D231/18 , C07D231/22 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/10 , C07D409/12 , C07D411/04 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D498/04 , C07D521/00 , A01N43/84 , C07D413/02 , C07D417/02
CPC分类号： C07D231/12 , C07C45/292 , C07C45/455 , C07C49/80 , C07C49/835 , C07D231/16 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/12 , C07D411/04 , C07D413/10 , C07D413/12 , C07D417/04
摘要： The invention herein relates to titled compounds having the structure ##STR1## wherein the R.sub.1 -(R.sub.4).sub.n members are as defined in the claims. Characteristic features of these compounds are the haloalkyl R.sub.2 radical and cyclization of two R.sub.4 members at the meta and para positions of the phenyl ring to form a substituted benzoxazinone ring fused to the phenyl or benzthiazinone ring. Such compounds are useful as active ingredients in herbicidal compositions to control undesirable weeds in various crops.
摘要翻译： 本发明涉及具有结构“IMAGE”的标题化合物，其中R1-（R4）n构件如权利要求中所定义。 这些化合物的特征是卤代烷基R2基和两个R 4成员在苯环的间位和对位环化，形成与苯基或苯并噻嗪酮环稠合的取代的苯并恶嗪酮环。 这些化合物可用作除草组合物中的活性成分，以控制各种作物中的不期望的杂草。
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公开(公告)号：US07902373B2
公开(公告)日：2011-03-08
申请号：US11954799
申请日：2007-12-12
申请人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer, Jr. , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
发明人： Tanisha D. Blake , Bruce C. Hamper , Wei Huang , James R. Kiefer, Jr. , Joseph B. Moon , Bradley E. Neal , Kirk L. Olson , Matthew J. Pelc , Barbara A. Schweitzer , Atli Thorarensen , John I. Trujillo , Steven R. Turner
IPC分类号： A01N43/40 , C07D213/62
CPC分类号： C07D401/12 , C07D213/82 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂合物，其中取代基如本文所定义，含有这些化合物的组合物以及这些化合物用于治疗各种疾病和病症例如哮喘的用途。
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公开(公告)号：US06956052B2
公开(公告)日：2005-10-18
申请号：US10247096
申请日：2002-09-19
申请人： Arija A. Bergmanis , Michael Clare , Joyce Z. Crich , Lifeng Geng , Timothy J. Hagen , Gunnar J. Hanson , Stephen C. Houdek , He Huang , Donna M. Iula , Francis J. Koszyk , Shuyuan Liao , Scott B. Mohler , Maria Nguyen , Richard A. Partis , Michael A. Stealey , Michael B. Tollefson , Richard M. Weier , Xiangdong Xu , Dominique Bonafoux , Theresa R. Fletcher , Bruce C. Hamper , Patrick J. Lennon , Subo Liao , Suzanne Metz , David S. Oburn , Thomas J. Owen , Angela M. Scates , Michael L. Vazquez , Serge G. Wolfson
发明人： Arija A. Bergmanis , Michael Clare , Joyce Z. Crich , Lifeng Geng , Timothy J. Hagen , Gunnar J. Hanson , Stephen C. Houdek , He Huang , Donna M. Iula , Francis J. Koszyk , Shuyuan Liao , Scott B. Mohler , Maria Nguyen , Richard A. Partis , Michael A. Stealey , Michael B. Tollefson , Richard M. Weier , Xiangdong Xu , Dominique Bonafoux , Theresa R. Fletcher , Bruce C. Hamper , Patrick J. Lennon , Subo Liao , Suzanne Metz , David S. Oburn , Thomas J. Owen , Angela M. Scates , Michael L. Vazquez , Serge G. Wolfson
IPC分类号： A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P19/02 , A61P25/04 , A61P29/00 , A61P35/00 , C07D231/54 , C07D333/62 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： C07D403/12 , C07D231/54 , C07D333/62 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
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