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公开(公告)号：US08618076B2
公开(公告)日：2013-12-31
申请号：US13076552
申请日：2011-03-31
申请人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
发明人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
CPC分类号： A61K31/7072 , A61K9/20 , A61K45/06 , C07B2200/13 , C07F9/2479 , C07H19/06 , C07H19/10 , C07H23/00
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译： 本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。
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公开(公告)号：US20110251152A1
公开(公告)日：2011-10-13
申请号：US13076552
申请日：2011-03-31
申请人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
发明人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
IPC分类号： A61K31/7072 , A61P31/14 , C07H19/10
CPC分类号： A61K31/7072 , A61K9/20 , A61K45/06 , C07B2200/13 , C07F9/2479 , C07H19/06 , C07H19/10 , C07H23/00
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译： 本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。
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公开(公告)号：US08859756B2
公开(公告)日：2014-10-14
申请号：US13076842
申请日：2011-03-31
申请人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang
发明人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang
IPC分类号： C07H19/04 , C07F9/6558 , C07F9/655 , C07H19/24 , C07F9/6561 , C07H19/10 , C07F9/24 , C07H19/044 , C07H19/207 , C07H19/052 , C07F7/18 , C07H19/06
CPC分类号： C07H19/10 , C07F7/1804 , C07F9/242 , C07F9/2458 , C07F9/65517 , C07F9/65586 , C07F9/65616 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/06 , C07H19/20 , C07H19/207 , C07H19/24
摘要： Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.
摘要翻译： 本文公开了含磷活性物质，它们作为治疗疾病的活性物质的用途和用于制备它们的立体选择性方法。 本文还公开了有用的合成中间体及其制备方法。
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公开(公告)号：US08716263B2
公开(公告)日：2014-05-06
申请号：US12645821
申请日：2009-12-23
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US20120316327A1
公开(公告)日：2012-12-13
申请号：US13491437
申请日：2012-06-07
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
IPC分类号： C07H1/00 , C07H19/20 , C07H19/213 , C07H15/207
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US09045520B2
公开(公告)日：2015-06-02
申请号：US13491437
申请日：2012-06-07
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanpalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanpalan Nagarathnam
IPC分类号： C07H1/00 , C07H5/02 , C07H15/04 , C07H19/20 , C07H19/167 , C07H19/213
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US08642756B2
公开(公告)日：2014-02-04
申请号：US12783680
申请日：2010-05-20
申请人： Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
发明人： Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
IPC分类号： A61K31/716 , C07H19/10
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/716 , A61K45/00 , C07F9/24 , C07F9/242 , C07F9/65586 , C07H1/00 , C07H17/02 , Y02A50/463 , Y02P20/55
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译： 本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。 这些化合物是RNA依赖性5 RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。
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公开(公告)号：US08563530B2
公开(公告)日：2013-10-22
申请号：US13076718
申请日：2011-03-31
申请人： Wonsuk Chang , Devan Naduthambi , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia , Hai-Ren Zhang
发明人： Wonsuk Chang , Devan Naduthambi , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia , Hai-Ren Zhang
CPC分类号： A61K31/7076 , C07H19/207
摘要： Disclosed herein is a compound represented by formula 1 or its hydrate thereof in crystalline or crystal-like form.
摘要翻译： 本文公开了结晶或晶体形式的由式1表示的化合物或其水合物。
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公开(公告)号：US08173621B2
公开(公告)日：2012-05-08
申请号：US12479075
申请日：2009-06-05
申请人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
发明人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
CPC分类号： C07D473/18 , C07H19/10 , C07H19/20
摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure:
摘要翻译： 用于治疗哺乳动物中的病毒感染的核苷衍生物的环磷酸酯，其为化合物，其立体异构体，由以下结构表示的盐（酸或碱加成盐），水合物，溶剂化物或其结晶形式：
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公开(公告)号：US08759510B2
公开(公告)日：2014-06-24
申请号：US13439991
申请日：2012-04-05
申请人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
发明人： Jinfa Du , Dhanapalan Nagarathnam , Ganapati Reddy Pamulapati , Bruce S. Ross , Michael Joseph Sofia
CPC分类号： C07D473/18 , C07H19/10 , C07H19/20
摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure:
摘要翻译： 用于治疗哺乳动物中的病毒感染的核苷衍生物的环磷酸酯，其为化合物，其立体异构体，由以下结构表示的盐（酸或碱加成盐），水合物，溶剂化物或其结晶形式：
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