公开(公告)号：US08557119B1

公开(公告)日：2013-10-15

申请号：US12880359

申请日：2010-09-13

Applicant: Kerry Howe ,  Joshua Goldman ,  Bruce Thomson

Inventor： Kerry Howe ,  Joshua Goldman ,  Bruce Thomson

IPC: B01D61/58 ,  B01D61/02 ,  B01D15/04 ,  B01D59/30

CPC classification number: B01D61/04 ,  B01D61/025 ,  B01D2311/04 ,  B01D2311/2623 ,  B01D2317/022 ,  C02F1/42 ,  C02F1/441 ,  C02F1/4693 ,  C02F9/00 ,  C02F2001/422 ,  C02F2001/425 ,  C02F2103/08 ,  Y02A20/131 ,  Y02A20/134

Abstract: A novel method for improving water recovery from desalination systems by the removal of cations and/or anions using ion exchange (IX) technology. The system described herein is particularly useful for water recovery in brackish ecosystems and is unique in that important features include recycling, regeneration, and recovery of key components, thereby reducing costs and waste products.

Abstract translation: 一种通过使用离子交换（IX）技术去除阳离子和/或阴离子来改善脱盐系统的水回收的新方法。 本文描述的系统特别适用于微咸水生态系统中的水回收，并且是独特的，因为重要特征包括关键组分的回收，再生和回收，从而降低成本和废物。

公开(公告)号：US20210317026A1

公开(公告)日：2021-10-14

申请号：US17301617

申请日：2021-04-09

Applicant: Bruce Thomson ,  Kerry Howe

Inventor： Bruce Thomson ,  Kerry Howe

IPC: C02F9/00 ,  C01D3/06 ,  C01F5/14 ,  C04B11/26

Abstract: A novel process for treatment of low quality or brackish water that allows increased recovery of high quality water, recovers commodity minerals and reduces the volume of water and mass of solids that are disposed from the process.

公开(公告)号：US08115165B2

公开(公告)日：2012-02-14

申请号：US12788391

申请日：2010-05-27

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/06 ,  H01J49/26

CPC classification number: H01J49/004 ,  H01J49/4245

Abstract: A mass spectrometer and method for performing high resolution mass spectrometry are provided, the mass spectrometer comprising an electrostatic trap and mass analyzer. The electrostatic trap comprises entrance and exit ends, entrance and exit end ion mirrors, a central field-free region, and a longitudinal axis. The mass analyzer receives ions from the exit end. Ions are admitted into the electrostatic trap via the entrance end, trapping ions in the electrostatic trap, the ions oscillating between the entrance and exit end ion mirrors along the axis. The electrostatic trap waits for the ions to separate into bunches different m/z values via the oscillating, and then excites a given bunch of ions of a given m/z value along the axis until at least a portion of the given bunch overcomes a barrier field at the exit end ion mirror, exiting the electrostatic trap for analysis, leaving behind remaining ions.

Abstract translation: 提供了用于进行高分辨率质谱的质谱仪和方法，该质谱仪包括静电捕集器和质量分析器。 静电捕获器包括入口和出口端，入口和出口端离子反射镜，中心无场区域和纵向轴线。 质量分析仪从出口端接收离子。 离子通过入口端进入静电捕获器，捕获静电捕获器中的离子，离子在入射和离开端离子反射镜之间沿轴线振荡。 静电捕获器等待离子通过振荡分离成不同m / z值的束，然后沿给定的m / z值激发给定的一束离子，直到给定束的至少一部分克服了屏障 在出口端离子反射镜处，离开静电阱进行分析，留下剩余的离子。

公开(公告)号：US20050098719A1

公开(公告)日：2005-05-12

申请号：US10433473

申请日：2001-12-14

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/4225 ,  H01J49/0081 ,  H01J49/40

Abstract: A method and apparatus are provided for effecting multiple mass selection or analysis steps. Fundamentally, the technique is based on moving ions in different directions through separate components of a mass spectrometer apparatus. To effect different steps, a precursor ion is selected in a first mass selector, and then passed into a collision cell, to effect fragmentation or reaction with a gas, to generate fragment or product ions. The generated product ions are then passed back into the first mass selector, and preferably back into an upstream ion trap. The product ions then pass through the first mass selector again, to select a desired product ion, for further fragmentation and analysis. These steps can be repeated a number of times. A final mass analysis step can be effected in either a time-of-flight section or other mass analyzer. The invention enables conventional triple quadrupole mass spectrometers and QqTOF mass spectrometers to effect multiple MS steps.

Abstract translation: 提供了一种实现多个质量选择或分析步骤的方法和装置。 基本上，该技术基于通过质谱仪装置的分开的部件沿不同方向移动离子。 为了实现不同的步骤，在第一质量选择器中选择前体离子，然后进入碰撞池，以使其与气体发生碎裂或反应，产生碎片或产物离子。 产生的产物离子然后被传回第一质量选择器，并且优选地返回到上游离子阱。 然后，产物离子再次通过第一质量选择器，以选择所需的产物离子，用于进一步的碎裂和分析。 这些步骤可以重复多次。 最后的质量分析步骤可以在飞行时间段或其他质量分析仪中进行。 本发明使传统的三重四极杆质谱仪和QqTOF质谱仪能够实现多个MS步骤。

公开(公告)号：US20090134322A1

公开(公告)日：2009-05-28

申请号：US12275597

申请日：2008-11-21

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: B01D59/44

CPC classification number: H01J49/004 ,  G01N27/624

Abstract: An apparatus and method of analyzing ions is described in which a Differential Mobility Analyzer (DMA) is combined with an analysis device. The DMS can be operated in first and second modes of operation to produce a plurality of ions that are sampled and analyzed by the analysis device. In the first mode of operation the DMA is configured to enable ion mobility separation and the analysis device samples and analyzes ions having ion mobility in a certain range of ion mobility and in the second mode of operation the DMA is configured to disable ion mobility separation and the analysis device samples and analyzes ions without discrimination based on ion mobility.

Abstract translation: 描述了分析离子的装置和方法，其中差分移动分析器（DMA）与分析装置组合。 DMS可以在第一和第二操作模式下操作，以产生由分析装置采样和分析的多个离子。 在第一操作模式中，DMA被配置为启用离子迁移率分离，并且分析装置对在离子迁移率的一定范围内具有离子迁移率的离子进行采样和分析，并且在第二操作模式中，DMA被配置为禁用离子迁移率分离， 分析装置基于离子迁移率对不分离的离子进行样品和分析。

公开(公告)号：US07145133B2

公开(公告)日：2006-12-05

申请号：US10433473

申请日：2001-12-14

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: H01J49/26

CPC classification number: H01J49/4225 ,  H01J49/0081 ,  H01J49/40

Abstract: A method and apparatus are provided for effecting multiple mass selection or analysis steps. Fundamentally, the technique is based on moving ions in different directions through separate components of a mass spectrometer apparatus. To effect different steps, a precursor ion is selected in a first mass selector, and then passed into a collision cell, to effect fragmentation or reaction with a gas, to generate fragment or product ions. The generated product ions are then passed back into the first mass selector, and preferably back into an upstream ion trap. The product ions then pass through the first mass selector again, to select a desired product ion, for further fragmentation and analysis. These steps can be repeated a number of times. A final mass analysis step can be effected in either a time-of-flight section or other mass analyzer. The invention enables conventional triple quadrupole mass spectrometers and QqTOF mass spectrometers to effect multiple MS steps.

Abstract translation: 提供了一种实现多个质量选择或分析步骤的方法和装置。 基本上，该技术基于通过质谱仪装置的分开的部件沿不同方向移动离子。 为了实现不同的步骤，在第一质量选择器中选择前体离子，然后进入碰撞池，以使其与气体发生碎裂或反应，产生碎片或产物离子。 产生的产物离子然后被传回第一质量选择器，并且优选地返回到上游离子阱。 然后，产物离子再次通过第一质量选择器，以选择所需的产物离子，用于进一步的碎裂和分析。 这些步骤可以重复多次。 最后的质量分析步骤可以在飞行时间段或其他质量分析仪中进行。 本发明使传统的三重四极杆质谱仪和QqTOF质谱仪能够实现多个MS步骤。

公开(公告)号：US5248875A

公开(公告)日：1993-09-28

申请号：US873149

申请日：1992-04-24

Applicant: Donald Douglas ,  Bruce Thomson ,  Jay Corr ,  James Hager

Inventor： Donald Douglas ,  Bruce Thomson ,  Jay Corr ,  James Hager

IPC: G01N27/62 ,  H01J49/32 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/005

Abstract: A method is provided of increasing the resolution in a tandem mass spectrometer having a first quadrupole Q1 to select a parent ion, a second quadrupole Q2 which contains a target gas and forms a collision cell, and a third or analyzing quadrupole Q3 which generates a mass spectrum from daughter ions from Q2. In the method, the target thickness of the target gas in Q2 is held at least at 1.32.times.10.sup.15 cm.sup.-2, preferably at least 3.30.times.10.sup.15 cm.sup.-2, and the DC offset voltage between Q2 and Q3 is kept low or zero. This greatly improves the resolution available in Q3. Q3 is therefore operated with at least unit resolution, and in some cases with resolution of 1/2 or 1/3 amu, making it possible to resolve isotopes of singly, doubly or triply charged daughter ions.

公开(公告)号：US07601952B2

公开(公告)日：2009-10-13

申请号：US11778954

申请日：2007-07-17

Applicant: Jim Hager ,  Bruce Thomson

Inventor： Jim Hager ,  Bruce Thomson

IPC: H01J49/00

CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/4265 ,  H01J49/4285

Abstract: A method of operating a mass spectrometer having a rod set is provided. The rod set has a first end, a second end opposite to the first end, and a longitudinal axis extending between the first end and the second end. The method comprises a) admitting ions into the rod set; b) trapping at least some of the ions in the rod set by i) producing a first barrier field at a first end member adjacent to the first end of the rod set, ii) producing a second barrier field at a second end member adjacent to the second end of the rod set, and iii) providing an aggregate field comprising an RF field between the rods of the rod set; c) selecting a first selected mass to charge ratio of a first group of ions in the ions; d) determining a first excitement level of a selected characteristic of the aggregate field for the first group of ions; e) adjusting the selected characteristic of the aggregate field to the first excitement level to resonantly excite the first group of ions to mass selectively eject the first group of ions from the rod set past the barrier field; and, f) maintaining the selected characteristic of the aggregate field at the first excitement level during an excitement time interval wherein the excitation time interval is at least 1 millisecond.

Abstract translation: 提供了具有棒组的操作质谱仪的方法。 杆组具有第一端，与第一端相对的第二端和在第一端和第二端之间延伸的纵向轴线。 该方法包括：a）将离子进入棒组; b）通过以下步骤捕获所述棒组中的至少一些离子：i）在与所述棒组的第一端相邻的第一端构件处产生第一屏障场，ii）在邻近所述杆组的第二端构件处产生第二屏障场 所述杆组的第二端，以及iii）提供包括所述杆组的杆之间的RF场的聚集场; c）选择离子中的第一组离子的第一选择质量与电荷比; d）确定第一组离子的聚集场的选定特征的第一兴奋度; e）将聚集场的所选特征调整到第一兴奋水平以共振地激发第一组离子以质量选择性地从穿过屏障场的棒组中弹出第一组离子; 以及f）在所述激发时间间隔至少为1毫秒的兴奋时间间隔期间将所述聚集场的选定特性保持在所述第一兴奋度水平。

公开(公告)号：US20080014656A1

公开(公告)日：2008-01-17

申请号：US11769254

申请日：2007-06-27

Applicant: Bruce Thomson

Inventor： Bruce Thomson

IPC: G01N24/00

CPC classification number: H01J49/063 ,  H01J49/0072 ,  Y10T436/24

Abstract: A method of analyzing ions is provided having a first ion guide with first and second ends and introducing a first group of ions and a second group of ions of opposite polarity into the first ion guide, and applying an RF voltage potential to the first ion guide for confining the first and second groups of ions radially within the first ion guide. A first trapping barrier is provided to the first end of the first ion guide for trapping the first group of ions within the first ion guide and a second trapping barrier is provided to the second end of the first ion guide for trapping the second group of ions within the first ion guide and an axial field is provided for pushing the first group of ions toward the first trapping barrier and pushing the second group of ions toward the second trapping barrier.

Abstract translation: 提供了一种分析离子的方法，其具有第一和第二端的离子引导件，并将第一组离子和第二组相反极性的离子引入第一离子导向器中，并将RF电压电势施加到第一离子导向器 用于将第一和第二组离子径向限制在第一离子导向器内。 第一捕获屏障被提供到第一离子导向器的第一端，用于捕获第一离子引导体内的第一组离子，并且第二捕获势垒被提供到第一离子引导件的第二端以捕获第二组离子 在所述第一离子导向件内设置有轴向场，用于将所述第一组离子推向所述第一捕获阻挡层并将所述第二组离子推向所述第二捕获屏障。

公开(公告)号：US20070057178A1

公开(公告)日：2007-03-15

申请号：US11222971

申请日：2005-09-12

Applicant: Igor Chernushevich ,  Alexandre Loboda ,  Bruce Thomson ,  Andrew Krutchinsky

Inventor： Igor Chernushevich ,  Alexandre Loboda ,  Bruce Thomson ,  Andrew Krutchinsky

IPC: H01J49/06

CPC classification number: H01J49/063 ,  H01J49/107

Abstract: A multi-device interface for use in mass spectrometry for interfacing one or more ion sources to one or more downstream devices. The multi-device interface comprises three or more multipole rod sets configured as either an input rod set or an output rod set depending on potentials applied to the multipole rod sets. The multipole rod sets configured as an input rod set are connectable to the one or more ion sources for receiving generated ions therefrom and sending the ions to at least one multipole rod set configured as an output multipole rod set. The output multipole rod sets are connectable to a downstream device for sending the generated ions thereto. At least two of the multipole rod sets are configured as input rod sets or at least two of the multipole rod sets are configured as output rod sets.

Abstract translation: 用于质谱法的多器件界面，用于将一个或多个离子源连接到一个或多个下游装置。 多器件接口包括三个或更多个多极杆组，其被配置为根据施加到多极杆组的电位的输入杆组或输出杆组。 配置为输入杆组的多极棒组可连接到一个或多个离子源，用于从其接收生成的离子，并将离子发送到被配置为输出多极棒组的至少一个多极棒组。 输出多极杆组可连接到用于将产生的离子发送到其的下游装置。 多极杆组中的至少两个被配置为输入杆组，或者至少两个多极杆组被配置为输出杆组。