公开(公告)号：US20060192965A1

公开(公告)日：2006-08-31

申请号：US11335072

申请日：2006-01-18

申请人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

发明人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

IPC分类号： G01N21/00

CPC分类号： A61B5/4504 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/417 ,  A61B5/4509

摘要： A method and apparatus for assessing bone tissue comprises the steps of and means for: exposing a sample to nonionizing radiation; detecting nonionizing radiation after transit in the bone tissue; measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

摘要翻译： 用于评估骨组织的方法和装置包括以下步骤和装置：将样品暴露于非离子辐照; 检测骨组织中过渡后的非放电辐射; 使用连续波模型，频域模型或波模型和频域模型的组合，从检测到的非离子化辐射测量光学特性以表征整个所选光谱范围内的骨组织; 以及根据测量的光学性质确定骨组织的组成，结构，生理学或其组合。

公开(公告)号：US20060184043A1

公开(公告)日：2006-08-17

申请号：US11336065

申请日：2006-01-19

申请人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Frederic Bevilacqua

发明人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Frederic Bevilacqua

IPC分类号： A61B6/00

CPC分类号： G01N21/4795 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/7257 ,  A61B5/726 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6491

摘要： An improvement in a method for quantitative modulated imaging to perform depth sectioned reflectance or transmission imaging in a turbid medium, such as human or animal tissue is directed to the steps of encoding periodic pattern of illumination preferably with a fluorescent excitation wavelength when exposing a turbid medium to the periodic pattern to provide depth-resolved discrimination of structures within the turbid medium; and reconstructing a non-contact three dimensional image of the structure within a turbid medium. As a result, wide field imaging, separation of the average background optical properties from the heterogeneity components from a single image, separation of superficial features from deep features based on selection of spatial frequency of illumination, or qualitative and quantitative structure, function and composition information is extracted from spatially encoded data.

摘要翻译： 用于在诸如人或动物组织的混浊介质中进行深度切片反射或透射成像的定量调制成像方法的改进涉及以下步骤：当暴露混浊介质时，优选用荧光激发波长编码周期性图案 以提供在混浊介质内的结构的深度分辨鉴别的周期性图案; 以及在混浊介质内重构所述结构的非接触三维图像。 因此，宽场成像，将平均背景光学性质与异质性成分从单一图像分离，基于选择照明空间频率或定性和定量结构，功能和成分信息，将表面特征与深层特征分离 从空间编码数据中提取出来。

公开(公告)号：US6151676A

公开(公告)日：2000-11-21

申请号：US989875

申请日：1997-12-24

申请人： David Cuccia ,  Michael A. Epstein ,  Michael S. Pasieka

发明人： David Cuccia ,  Michael A. Epstein ,  Michael S. Pasieka

IPC分类号： G06F7/58 ,  G09C1/00 ,  H04L9/30 ,  H04L9/00

CPC分类号： H04L9/3013 ,  H04L9/002 ,  H04L9/3247 ,  H04L2209/08

摘要： In a public key cryptosystem employing the El-Gamal algorithm, secret fresh random numbers are generated at a server and private keys of users, as encrypted with a symmetric algorithm by using individual user identifying keys determined by hashing the users' respective passphrases or biometric information (fingerprint, voiceprint, retina scan, or face scan) are maintained in a store accessible to the server, and the fresh random numbers and encrypted private keys are transmitted to the user equipment when needed via a network which is not secure. In order to prevent an attacker from discovering the random numbers or employing formerly used random numbers in a block replay attack, an interchange in the nature of a challenge response protocol is employed which passes at least one secret fresh random number from the server to the user equipment while also authenticating the user to the server. In this interchange, a first random number to be distributed to the user for use in signing a document and a second random number which is to be used by the user in forming a signature of a hashing together of the first and second random numbers as part of the challenge response protocol, are supplied to the user equipment in encrypted form together with a freshness value, and a signature by the server of a hashing together of the first and second random numbers and the freshness value.

摘要翻译： 在采用El-Gamal算法的公钥密码系统中，秘密新鲜随机数在用户的服务器和私钥生成，用对等算法加密，通过使用通过散列用户相应的密码或生物特征信息确定的个别用户识别密钥 （指纹，声纹，视网膜扫描或脸部扫描）被维护在服务器可访问的商店中，并且当需要时通过不安全的网络将新鲜的随机数和加密的私钥传送到用户设备。 为了防止攻击者在块重放攻击中发现随机数或采用以前使用的随机数，采用质询响应协议的性质的交换，其将来自服务器的至少一个秘密新鲜随机数传递给用户 设备同时也将用户认证给服务器。 在该交换中，要分配给用户以用于签署文档的第一随机数和第二随机数，第二随机数将由用户在形成第一和第二随机数的散列的签名时使用，作为部分 挑战响应协议的加密形式与新鲜度值一起被提供给用户设备，服务器通过散列在一起的第一和第二随机数和新鲜度值的签名。

公开(公告)号：US09220412B2

公开(公告)日：2015-12-29

申请号：US12950805

申请日：2010-11-19

申请人： David Cuccia

发明人： David Cuccia

IPC分类号： A61B6/00 ,  A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/0059 ,  A61B5/7271

摘要： Method and apparatus for obtaining qualitative and quantitative analysis of the optical properties or structures of tissue or turbid medium at one or more wavelengths via 1) detection at a single spatial location on the surface of a turbid medium (such as tissue) under two or more structured light conditions or 2) detection at two or more spatial locations on the surface under a single structured light condition.

摘要翻译： 用于通过1）在两个或更多个波长处的混浊介质（例如组织）的表面上的单个空间位置处检测来获得在一个或多个波长处的组织或混浊介质的光学性质或结构的定性和定量分析的方法和装置 结构光条件或2）在单个结构光条件下在表面上的两个或更多个空间位置处的检测。

公开(公告)号：US20050256538A1

公开(公告)日：2005-11-17

申请号：US11189956

申请日：2005-07-25

申请人： David Cuccia

发明人： David Cuccia

IPC分类号： A61F5/00 ,  A61G13/00 ,  A61G13/12 ,  A61H20060101 ,  A61H1/02

CPC分类号： A61H1/0237 ,  A61G13/009 ,  A61G13/12 ,  A61G13/121 ,  A61G13/1225 ,  A61G13/1235 ,  A61G13/124 ,  A61G13/1245 ,  A61G13/125 ,  A61G13/1255 ,  A61G2200/322 ,  A61G2200/325 ,  A61H1/0222 ,  A61H1/0229

摘要： A calf/foot support and treatment table for extension, flexion, traction, distraction and lateral movement of the body of a patient includes a base adapted to rest upon a floor, and a system support assembly having an upper end and a lower end integrally secured to the base, a rigid support platform having a lower part and an upper part, said support platform pivotally secured to a pivot axle of said system support assembly; a lumbar support assembly disposed on said lower part of said support platform; and a calf/foot support assembly for linear traction.

摘要翻译： 用于患者身体的伸展，弯曲，牵引，牵引和侧向运动的小腿/脚部支撑和治疗台包括适于搁置在地板上的基座和具有上端和下端整体固定的系统支撑组件 具有下部和上部的刚性支撑平台，所述支撑平台枢转地固定到所述系统支撑组件的枢转轴上; 设置在所述支撑平台的所述下部的腰部支撑组件; 以及用于线性牵引的小腿/脚支撑组件。

公开(公告)号：US20110124988A1

公开(公告)日：2011-05-26

申请号：US12950805

申请日：2010-11-19

申请人： David Cuccia

发明人： David Cuccia

IPC分类号： A61B5/1455

CPC分类号： A61B5/0075 ,  A61B5/0059 ,  A61B5/7271

摘要： Method and apparatus for obtaining qualitative and quantitative analysis of the optical properties or structures of tissue or turbid medium at one or more wavelengths via 1) detection at a single spatial location on the surface of a turbid medium (such as tissue) under two or more structured light conditions or 2) detection at two or more spatial locations on the surface under a single structured light condition.

摘要翻译： 用于通过1）在两个或更多个波长下的混浊介质（例如组织）的表面上的单个空间位置处的检测来获得在一个或多个波长处的组织或混浊介质的光学性质或结构的定性和定量分析的方法和装置 结构光条件或2）在单个结构光条件下在表面上的两个或更多个空间位置处的检测。

公开(公告)号：US20100210931A1

公开(公告)日：2010-08-19

申请号：US12418515

申请日：2009-04-03

申请人： David Cuccia ,  Anthony J. Durkin ,  Joon S. You

发明人： David Cuccia ,  Anthony J. Durkin ,  Joon S. You

IPC分类号： A61B5/1455 ,  A61B6/00

CPC分类号： A61B5/0059 ,  A61B5/02028 ,  A61B5/14551 ,  A61B5/445

摘要： A method of noncontact imaging for performing qualitative and quantitative analysis of wounds includes the step of performing structured illumination of surface and subsurface tissue by both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. Structured illumination of a skin flap is performed to monitor a burn wound, a diabetic ulcer, a decubitis ulcer, a peripheral vascular disease, a skin graft, and/or tissue response to photomodulation. Quantitative imaging of optical properties is performed of superficial (0-5 mm depth) tissues in vivo. The step of quantitative imaging of optical properties of superficial (0-5 mm depth) tissues in vivo comprises pixel-by-pixel demodulating and diffusion-model fitting or model-based analysis of spatial frequency data to extract the local absorption and reduced scattering optical coefficients.

摘要翻译： 用于对伤口进行定性和定量分析的非接触成像方法包括通过漫射光学层析成像和在单个测量平台内的组织光学性质的快速，宽场定量映射来执行表面和表面下组织的结构照明的步骤。 执行皮瓣的结构照明以监测烧伤伤口，糖尿病性溃疡，褥疮性溃疡，外周血管疾病，皮肤移植物和/或组织对光调制的反应。 光学性质的定量成像在体内进行表面（0-5mm深度）组织。 表面（0-5mm深度）组织的光学性质的定量成像步骤包括逐像素解调和扩散模拟拟合或空间频率数据的基于模型的分析，以提取局部吸收和减少散射光学 系数。

公开(公告)号：US08509879B2

公开(公告)日：2013-08-13

申请号：US12016918

申请日：2008-01-18

申请人： Anthony J. Durkin ,  David Cuccia ,  Bruce J. Tromberg ,  Amaan Mazhar ,  Bernard Choi

发明人： Anthony J. Durkin ,  David Cuccia ,  Bruce J. Tromberg ,  Amaan Mazhar ,  Bernard Choi

IPC分类号： A61B6/00

CPC分类号： A61B5/0073 ,  A61B5/4094 ,  G01N21/4795 ,  G01N21/6456

摘要： An apparatus for wide-field functional imaging (WiFI) of tissue includes a spatially modulated reflectance/fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.

摘要翻译： 用于组织的广域功能成像（WiFI）的装置包括能够跨越空间尺度进行定量地下成像的空间调制反射/荧光成像（SI）装置，以及能够在空间上进行定量地下成像的激光散斑成像（LSI）装置 使用与（SI）设备集成的刻度。 SI装置和LSI装置能够独立地提供组织功能状态的定量测量。

公开(公告)号：US20090118622A1

公开(公告)日：2009-05-07

申请号：US12016918

申请日：2008-01-18

申请人： Anthony J. Durkin ,  David Cuccia ,  Bruce J. Tromberg ,  Amaan Mazhar ,  Bernard Choi

发明人： Anthony J. Durkin ,  David Cuccia ,  Bruce J. Tromberg ,  Amaan Mazhar ,  Bernard Choi

IPC分类号： A61B6/00

CPC分类号： A61B5/0073 ,  A61B5/4094 ,  G01N21/4795 ,  G01N21/6456

摘要： An apparatus for wide-field functional imaging (WIFI) of tissue includes a spatially modulated reflectance/fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.

摘要翻译： 用于组织的广域功能成像（WIFI）的装置包括能够跨越空间尺度进行定量地下成像的空间调制反射/荧光成像（SI）装置，以及能够在空间上进行定量地下成像的激光散斑成像（LSI）装置 使用与（SI）设备集成的刻度。 SI装置和LSI装置能够独立地提供组织功能状态的定量测量。

公开(公告)号：US06958815B2

公开(公告)日：2005-10-25

申请号：US10391166

申请日：2003-03-18

申请人： Frederic Bevilacqua ,  David Cuccia ,  Anthony J. Durkin ,  Bruce J. Tromberg

发明人： Frederic Bevilacqua ,  David Cuccia ,  Anthony J. Durkin ,  Bruce J. Tromberg

IPC分类号： G01N21/49 ,  G01N21/55

CPC分类号： G01N21/49

摘要： Illumination with a pattern of light allows for subsurface imaging of a turbid medium or tissue, and for the determination of the optical properties over a large area. Both the average and the spatial variation of the optical properties can be noninvasively determined. Contact with the sample or scanning is not required but may be desired. Subsurface imaging is performed by filtering the spectrum of the illumination in the Fourier domain but other filtering approaches, such as wavelet transform, principle component filter, etc may be viable as well. The depth sensitivity is optimized by changing the spatial frequency of illumination. A quantitative analysis of the average optical properties and the spatial variation of the optical properties is obtained. The optical properties, i.e. reduced scattering and absorption coefficients are determined from the modulated transfer function, MTF.

摘要翻译： 具有光图案的照明允许混浊的介质或组织的地下成像，并且用于确定大面积上的光学性质。 光学性质的平均和空间变化都可以非侵入性地确定。 不需要与样品接触或扫描，但可能需要。 通过对傅立叶域中的照明光谱进行滤波来进行地下成像，但也可以采用小波变换，主成分滤波等其他滤波方法。 通过改变照明的空间频率来优化深度灵敏度。 获得光学特性的平均光学性质和空间变化的定量分析。 从调制传递函数MTF确定光学性质，即减小的散射和吸收系数。