公开(公告)号：US07409328B1

公开(公告)日：2008-08-05

申请号：US10713754

申请日：2003-11-13

申请人： Bruce W. McGaughy ,  Jun Kong ,  Peter Frey ,  Jaideep Muhkerjee

发明人： Bruce W. McGaughy ,  Jun Kong ,  Peter Frey ,  Jaideep Muhkerjee

IPC分类号： G06F17/50

CPC分类号： G06F17/5036

摘要： A system for communicating simulation solutions between circuit components in a hierarchical data structure includes a simulator module having one or more computer programs for representing the circuit as a hierarchically arranged set of branches, which includes a root branch and a plurality of other branches logically organized in a graph. The hierarchically arranged set of branches includes a first branch that contains one or more driver leaf circuits and a second branch that also contains one or more receiver leaf circuits, where the first branch and second branch are interconnected in the graph through a third branch at a higher hierarchical level in the graph than the first and second branches. The simulator module further includes computer programs for simulating operation of the one or more driver leaf circuits and the one or more receiver leaf circuits, together, without simulating operation of the third branch to determine a first set of changes in signal conditions shared by the one or more driver leaf circuits and the one or more receiver leaf circuits.

摘要翻译： 用于在分层数据结构中的电路组件之间传递模拟解决方案的系统包括具有一个或多个计算机程序的模拟器模块，该计算机程序用于将该电路表示为分层布置的分支集，其包括根分支和逻辑上组织在一起的多个其他分支 一张图。 分层布置的分支集合包括包含一个或多个驱动器叶电路的第一分支和还包含一个或多个接收器叶电路的第二分支，其中第一分支和第二分支通过第三分支在图中互连， 图中的分级水平高于第一和第二分支。 模拟器模块还包括用于在不模拟第三分支的操作​​的情况下模拟一个或多个驱动器叶电路和一个或多个接收器叶电路的操作的计算机程序，以确定由该一个共享的信号条件的第一组变化 或更多的驱动器叶电路和一个或多个接收器叶电路。

公开(公告)号：US07269541B1

公开(公告)日：2007-09-11

申请号：US10713753

申请日：2003-11-13

申请人： Bruce W. McGaughy ,  Peter Frey ,  Jun Kong ,  Baolin Yang

发明人： Bruce W. McGaughy ,  Peter Frey ,  Jun Kong ,  Baolin Yang

IPC分类号： G06F17/50

CPC分类号： G06F17/5022

摘要： A system for supporting multi-rate simulation of a circuit having a hierarchical data structure includes a simulator module having one or more computer programs for 1) partitioning the circuit into a plurality of group circuits, each group circuit includes one or more leaf circuits, where each leaf circuit produces a predictable set of output signals with a given set of input signals, 2) storing the group circuits in a scheduled event queue in accordance with priority in time which the group circuits need to be simulated, 3) retrieving from the scheduled event queue a set of group circuits for simulation within a predetermined time period, 4) distributing the set of group circuits into a set of predefined event lists, where each of the predefined event list stores one or more group circuits of a corresponding event type, and 5) simulating the one or more group circuits in each of the predefined event list in accordance with a rate of change of signal conditions of each individual group circuit. Hence, the system provides an efficient way to support multi-rate simulation by dynamically scheduling and synchronizing multiple group simulation event types and by communicating corresponding isomorphic activities through an efficient port connectivity interface.

摘要翻译： 一种用于支持具有分层数据结构的电路的多速率仿真的系统包括具有一个或多个计算机程序的模拟器模块，用于1）将电路划分为多个组电路，每个组电路包括一个或多个叶电路，其中 每个叶片电路产生具有给定的一组输入信号的可预测的一组输出信号，2）根据组电路需要模拟的时间优先级将组电路存储在调度事件队列中; 3）从调度的 事件队列一组用于在预定时间段内进行模拟的组电路，4）将所述组电路组分配成一组预定事件列表，其中每个预定事件列表存储相应事件类型的一个或多个组电路， 以及5）根据每个单独组的信号条件的变化率来模拟每个预定事件列表中的一个或多个组电路 电路。 因此，该系统通过动态调度和同步多组模拟事件类型并通过有效的端口连接接口传达相应的同构活动来提供有效的方式来支持多速率模拟。

公开(公告)号：US07024652B1

公开(公告)日：2006-04-04

申请号：US10713751

申请日：2003-11-13

申请人： Bruce W. McGaughy ,  Peter Frey ,  Jun Kong ,  Baolin Yang

发明人： Bruce W. McGaughy ,  Peter Frey ,  Jun Kong ,  Baolin Yang

IPC分类号： G06F17/50

CPC分类号： G06F17/5036

摘要： A system for adaptive partitioning of circuit components during simulating of a circuit having a hierarchical data structure includes a simulator module having one or more computer programs for 1) selecting a group of leaf circuits from the first branch and the second branch for simulation, where each leaf circuit is represented by a matrix comprising a set of equations, 2) determining a strength of coupling between two or more leaf circuits of the group in accordance with a set of predetermined electrical coupling criteria, 3) if two or more leaf circuits are deemed be strongly coupled, combining the corresponding matrix of each strongly coupled leaf circuit into a combined matrix, and 4) performing computation for the two or more strongly coupled leaf circuits in accordance with the combined matrix. The system adaptively adjusts the group circuit matrix for computing a group of circuits according to the strength of coupling between the circuits. Hence, it achieves higher simulation performance by reducing either the size of the solver matrix when the circuits are loosely connected to each other, or by reducing the number of computational repetitions due to the communication of changes of signal conditions between circuits by combining the individual circuit matrices when such circuits are closely coupled to each other.

摘要翻译： 用于在具有分层数据结构的电路的仿真期间对电路组件进行自适应分配的系统包括具有一个或多个计算机程序的模拟器模块，用于1）从第一分支和第二分支中选择一组叶电路用于模拟，其中每个 叶片电路由包括一组方程的矩阵表示，2）根据一组预定的电耦合标准确定该组的两个或更多叶片电路之间的耦合强度，3）如果认为两个或多个叶片电路 强耦合，将每个强耦合叶电路的相应矩阵组合成组合矩阵，以及4）根据组合矩阵对两个或更多个强耦合叶电路执行计算。 该系统根据电路之间的耦合强度自适应地调整用于计算一组电路的组电路矩阵。 因此，通过在电路彼此松耦合时减小求解器矩阵的大小，或者通过将各个电路之间的信号状态的通信减少而导致的计算重复次数减少，从而实现更高的仿真性能 当这种电路彼此紧密耦合时的矩阵。

公开(公告)号：US07272805B2

公开(公告)日：2007-09-18

申请号：US10993686

申请日：2004-11-19

申请人： Bruce W. McGaughy ,  Peter Frey ,  Boris Krichevskiy

发明人： Bruce W. McGaughy ,  Peter Frey ,  Boris Krichevskiy

IPC分类号： G06F17/50

CPC分类号： G06F17/5045

摘要： System and method for converting a flat netlist into a hierarchical netlist are disclosed. The method includes receiving the flat netlist, traversing the flat netlist in a bottom-up fashion, and identifying isomorphic subcircuits in the flat netlist. The method further includes creating a set of cross-coupling capacitor collections for storing information of cross-coupling capacitors, creating a set of net collections for storing information of isomorphic subcircuits, traversing each hierarchical level of the hierarchical netlist in a top-down fashion, and generating the hierarchical netlist using the set of net collections and the set of cross-coupling capacitor collections.

摘要翻译： 公开了将平面网表转换为分级网表的系统和方法。 该方法包括接收平面网表，以自下而上的方式穿过平面网表，以及识别平面网表中的同构子电路。 该方法还包括创建一组交叉耦合电容器集合，用于存储交叉耦合电容器的信息，创建一组用于存储同构子电路的信息的网络集合，以自顶向下的方式遍历分级网表的每个层级， 以及使用所述集合集合和所述交叉耦合电容器集合来生成所述分级网表。

公开(公告)号：US20150374807A1

公开(公告)日：2015-12-31

申请号：US14788896

申请日：2015-07-01

申请人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Martin Lueoend ,  Matthias Staufenbiel ,  Peter Frey

发明人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Martin Lueoend ,  Matthias Staufenbiel ,  Peter Frey

IPC分类号： A61K39/00

CPC分类号： A61K39/0007 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64

摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.

摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含有序和重复的抗原或抗原决定簇，特别是Aβ肽-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫，应答。

公开(公告)号：US20140027230A1

公开(公告)日：2014-01-30

申请号：US13950374

申请日：2013-07-25

申请人： Georg Mencher ,  Peter Frey ,  Jörg Sudau

发明人： Georg Mencher ,  Peter Frey ,  Jörg Sudau

IPC分类号： F16H41/04

CPC分类号： F16H45/02 ,  F16H2041/246 ,  F16H2045/0226 ,  F16H2045/0263 ,  F16H2045/0284

摘要： A starting element for transmitting torque from a drive-side rotational input (14) of the starting element to a driven hub (8) includes a hydrodynamic torque converter (4) which has a turbine coupled to the driven hub (8) so as to be fixed with respect to rotation relative to it and which comprises a turbine shell (56) with turbine blades (22) arranged therein. A maximum extension of the turbine shell (56) opposite an axial direction (12) terminates at a first axial position (53), and an impeller (20) located opposite the turbine in the axial direction (12). A stator (24) is arranged between the turbine and the impeller (22) and is coupled via a stator flange (58) to a freewheel (52) adjoining the driven hub (8) in an axial direction (12). A center of the freewheel (52) is located at a second axial position (54). A difference between the first axial position (53) and the second axial position (54) is greater than a predetermined minimum value.

摘要翻译： 用于将扭矩从起动元件的驱动侧旋转输入（14）传递到从动轮毂（8）的启动元件包括具有联接到从动轮毂（8）的涡轮的流体动力学变矩器（4），以便 相对于其旋转而被固定，并且其包括具有布置在其中的涡轮叶片（22）的涡轮壳体（56）。 涡轮壳体（56）的与轴向方向（12）相反的最大延伸部终止于第一轴向位置（53）和在轴向（12）处与涡轮机相对定位的叶轮（20）。 定子（24）布置在涡轮机和叶轮（22）之间，并且经由定子凸缘（58）被耦合到沿着轴向方向（12）邻接从动轮毂（8）的自由轮（52）。 自由轮（52）的中心位于第二轴向位置（54）。 第一轴向位置（53）和第二轴向位置（54）之间的差异大于预定的最小值。

公开(公告)号：US20130125538A1

公开(公告)日：2013-05-23

申请号：US13670695

申请日：2012-11-07

申请人： Peter Frey ,  Michael Heuler ,  Georg Mencher

发明人： Peter Frey ,  Michael Heuler ,  Georg Mencher

IPC分类号： F16C33/02 ,  F16C33/30

CPC分类号： F16C33/02 ,  F02N11/08 ,  F16C17/04 ,  F16C17/24 ,  F16C19/30 ,  F16C19/52 ,  F16C33/30 ,  F16C2202/30 ,  F16H41/24 ,  F16H57/021

摘要： A torque transmission device, particularly for a motor vehicle, for the transmission of a torque from a driving unit, particularly from an internal combustion engine, to a driven unit, particularly a transmission, has at least one bearing location which has at least one bearing support acting in axial and/or radial direction, wherein an insulation element preventing a flow of electric current is provided in the region of the at least one bearing location.

摘要翻译： 特别是用于机动车辆的扭矩传递装置用于将来自驱动单元，特别是内燃机的转矩传递到从动单元，特别是变速器的转矩传递装置具有至少一个轴承位置，其具有至少一个轴承 支撑件在轴向和/或径向方向上作用，其中在所述至少一个轴承位置的区域中提供防止电流流动的绝缘元件。

公开(公告)号：US20120020104A1

公开(公告)日：2012-01-26

申请号：US13259188

申请日：2010-03-29

申请人： Alois Biebl ,  Peter Frey ,  Ralf Vollmer

发明人： Alois Biebl ,  Peter Frey ,  Ralf Vollmer

IPC分类号： F21V15/01

CPC分类号： F21V25/00 ,  F21K9/00 ,  F21S41/192 ,  F21S45/48 ,  F21Y2115/10

摘要： An illumination unit for vehicle headlights may include a light-emitting diode device, a housing and an assembly board on which components of an operating circuit for operating the light-emitting diode device are arranged, wherein the housing and the assembly board define an interior space, wherein the assembly board has at least one electrically conductive inner layer that is connected to a ground reference potential of the operating circuit and on its surface the assembly board has at least one electrical contact surface which is contacted with at least one electrically conductive inner layer, and the housing has an electromagnetic shielding structure configured to provide electromagnetic shielding of the interior space, wherein the electromagnetic shielding structure is connected to the at least one electrical contact surface.

摘要翻译： 用于车辆前灯的照明单元可以包括发光二极管装置，壳体和组装板，其上布置有用于操作发光二极管装置的操作电路的部件，其中壳体和组装板限定内部空间 ，其中所述组装板具有至少一个导电内层，其连接到所述操作电路的接地参考电位，并且在其表面上，所述组装板具有至少一个电接触表面，所述至少一个电接触表面与至少一个导电内层 并且所述壳体具有电磁屏蔽结构，其构造成提供所述内部空间的电磁屏蔽，其中所述电磁屏蔽结构连接到所述至少一个电接触表面。

公开(公告)号：US20100277941A1

公开(公告)日：2010-11-04

申请号：US12743575

申请日：2008-11-17

申请人： Peter Frey ,  Christian Meier

发明人： Peter Frey ,  Christian Meier

IPC分类号： B60Q1/04

CPC分类号： F21V29/71 ,  F21S41/141 ,  F21S45/33 ,  F21S45/43 ,  F21S45/46 ,  F21S45/47 ,  F21S45/48 ,  F21V29/56 ,  F21V29/89 ,  F21Y2115/10

摘要： An LED headlight may include at least one heat-conducting element that extends from at least one heat source located in a headlight housing to at least one cooling element in such a way as to make thermal contact and which is arranged at least partially outside on the headlight housing, the heat-conducting element being movable.

摘要翻译： LED头灯可以包括至少一个导热元件，其从位于头灯壳体中的至少一个热源延伸到至少一个冷却元件，以便进行热接触并且至少部分地布置在 头灯壳体，导热元件可移动。

公开(公告)号：US07581951B2

公开(公告)日：2009-09-01

申请号：US10562939

申请日：2004-07-01

申请人： Karl-Heinz Lehmann ,  Peter Frey

发明人： Karl-Heinz Lehmann ,  Peter Frey

IPC分类号： A61G15/00

CPC分类号： A61G15/16

摘要： The invention relates to a treatment element which is used to receive dental hand instruments. Said treatment element comprises a base part (1) which is provided with connections (2; 39) and which is used to accommodate the instruments, and a instrument storage place (5; 15). Said treatment element comprises an exchangeable upper part (4; 12).

摘要翻译： 本发明涉及一种用于接收牙科手术器械的治疗元件。 所述治疗元件包括设置有连接件（2; 39）并用于容纳器械的基座部件（1），以及仪器存储部件（5; 15）。 所述处理元件包括可更换的上部部分（4; 12）。