公开(公告)号：US20190331692A1

公开(公告)日：2019-10-31

申请号：US16377837

申请日：2019-04-08

Applicant: Cambridge Enterprise Limited

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Pertti Jonathan Knowles

IPC: G01N33/68 ,  G01N27/447 ,  G01N15/02 ,  G01N33/52 ,  B01L3/00 ,  G01N33/50

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

公开(公告)号：US20180267054A1

公开(公告)日：2018-09-20

申请号：US15922082

申请日：2018-03-15

Applicant: Cambridge Enterprise Limited

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Knowles

IPC: G01N33/68 ,  B01L3/00 ,  G01N33/52 ,  G01N33/50

CPC classification number: G01N33/6845 ,  B01L3/502753 ,  B01L2200/0631 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0421 ,  G01N15/0266 ,  G01N27/447 ,  G01N33/50 ,  G01N33/52 ,  G01N2015/0038 ,  G01N2015/0288

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

公开(公告)号：US11959923B2

公开(公告)日：2024-04-16

申请号：US17314254

申请日：2021-05-07

Applicant: Cambridge Enterprise Limited

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Pertti Jonathan Knowles

IPC: G01N33/68 ,  B01L3/00 ,  G01N15/02 ,  G01N27/447 ,  G01N33/50 ,  G01N33/52 ,  G01N15/00

CPC classification number: G01N33/6845 ,  B01L3/502753 ,  G01N15/0266 ,  G01N27/447 ,  G01N33/50 ,  G01N33/52 ,  B01L2200/0631 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0421 ,  G01N2015/0038 ,  G01N2015/0288

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

公开(公告)号：US20210318330A1

公开(公告)日：2021-10-14

申请号：US17314254

申请日：2021-05-07

Applicant: Cambridge Enterprise Limited

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Pertti Jonathan Knowles

IPC: G01N33/68 ,  G01N33/50 ,  G01N33/52 ,  G01N15/02 ,  B01L3/00 ,  G01N27/447

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

公开(公告)号：US10386332B2

公开(公告)日：2019-08-20

申请号：US15307221

申请日：2015-04-30

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Therese Herling ,  Thomas Mueller ,  Tuomas Knowles

IPC: G01N27/447 ,  B01L3/00 ,  G01N15/02

Abstract: A method for analyzing a component is provided. The method includes the steps of: (iii) providing the electrophoretic or thermophoretic movement of the component into a second fluid flow; (iv) diverting a part of a first fluid flow, a part of the second fluid flow, or parts of the first fluid flow and the second fluid flow, wherein the diverted part is a third fluid flow which includes, the component; (v) contacting the third fluid flow with a fourth fluid flow, such as to form a laminar flow; (vi) providing the diffusion of the component into the fourth fluid flows.

公开(公告)号：US11029315B2

公开(公告)日：2021-06-08

申请号：US16377837

申请日：2019-04-08

Applicant: Cambridge Enterprise Limited

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Pertti Jonathan Knowles

IPC: B01L3/00 ,  G01N33/50 ,  B01J19/00 ,  G01N27/447 ,  G01N33/52 ,  G01N33/68 ,  G01N15/02 ,  G01N1/10 ,  G01N15/00

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

公开(公告)号：US10295545B2

公开(公告)日：2019-05-21

申请号：US15922082

申请日：2018-03-15

Applicant: Cambridge Enterprise Limited

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Knowles

IPC: B01L3/00 ,  G01N33/50 ,  G01N27/447 ,  B01J19/00 ,  G01N33/52 ,  G01N33/68 ,  G01N15/02 ,  G01N1/10 ,  G01N15/00

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

公开(公告)号：US09952222B2

公开(公告)日：2018-04-24

申请号：US15036455

申请日：2014-11-14

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Knowles

IPC: B01L3/00 ,  G01N33/68 ,  G01N33/50 ,  B01J19/00 ,  G01N33/52 ,  G01N27/447 ,  G01N15/02 ,  G01N1/10 ,  G01N15/00

CPC classification number: G01N33/6845 ,  B01L3/502753 ,  B01L2200/0631 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0421 ,  G01N15/0266 ,  G01N27/447 ,  G01N33/50 ,  G01N33/52 ,  G01N2015/0038 ,  G01N2015/0288

Abstract: A method for analyzing a component using a fluidic device. The method includes the steps of providing a distribution of the component across contacting first and second fluid flows; diverting a part of the first fluid flow, a part of the second fluid flow, or parts of the first fluid flow and the second fluid flow, wherein the diverted part includes the component; and analyzing the component in the diverted part of the fluid flow. Optionally the component may be labelled prior to the analyzing step. A flow apparatus for use in the method is also provided.