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公开(公告)号:US11878080B2
公开(公告)日:2024-01-23
申请号:US15508876
申请日:2015-09-04
Inventor: Tuomas Knowles , Ulyana Shimanovich , Christopher Dobson , David Weitz
CPC classification number: A61K9/4825 , A61K9/4833 , A61K9/5169 , B01J13/08
Abstract: The present invention provides capsules having a shell of material that comprises an assembly of a protein, and the capsule is optionally provided with a network of material within the shell that is an assembly of the protein. The assembly of the protein is obtained or obtainable by the aggregation of the protein, optionally together with another protein. The assembly is a non-covalent assembly of a protein.
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公开(公告)号:US20190331692A1
公开(公告)日:2019-10-31
申请号:US16377837
申请日:2019-04-08
Applicant: Cambridge Enterprise Limited
Inventor: Emma Yates , Christopher Dobson , Therese Herling , Tuomas Pertti Jonathan Knowles
Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.
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公开(公告)号:US20180267054A1
公开(公告)日:2018-09-20
申请号:US15922082
申请日:2018-03-15
Applicant: Cambridge Enterprise Limited
Inventor: Emma Yates , Christopher Dobson , Therese Herling , Tuomas Knowles
CPC classification number: G01N33/6845 , B01L3/502753 , B01L2200/0631 , B01L2200/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0421 , G01N15/0266 , G01N27/447 , G01N33/50 , G01N33/52 , G01N2015/0038 , G01N2015/0288
Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.
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公开(公告)号:US10670504B2
公开(公告)日:2020-06-02
申请号:US15921778
申请日:2018-03-15
Applicant: Cambridge Enterprise Limited
Inventor: Samuel Cohen , Tuomas Knowles , Christopher Dobson , Luke Rajah , Duncan White
IPC: G01N13/00 , B01F5/04 , B01F5/06 , B01F13/00 , G01N33/487
Abstract: Methods for determining the lateral diffusion of one or more components are provided.
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公开(公告)号:US09958369B2
公开(公告)日:2018-05-01
申请号:US14438145
申请日:2013-10-22
Applicant: CAMBRIDGE ENTERPRISE LIMITED
Inventor: Samuel Cohen , Tuomas Knowles , Christopher Dobson , Luke Rajah , Duncan White
IPC: G01N13/00 , B01F5/04 , B01F5/06 , B01F13/00 , G01N33/487
CPC classification number: G01N13/00 , B01F5/045 , B01F5/0647 , B01F13/0093 , G01N33/487 , G01N2013/003
Abstract: A method for determining the diffusion of one or more components, the method includes the steps of (i) providing a component fluid flow having one or more components; (ii) providing a blank fluid flow; (iii) bringing the flow (i) into contact with the flow (ii) in a large cross section channel, thereby to generate two laminar flows; (iv) permitting the laminar flows generated in (iii) to flow from the large cross section channel into a small cross section channel; measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow in the small cross section channel. Also provided is a diffusion method having the steps of measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow at a plurality of diffusion times.
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公开(公告)号:US11959923B2
公开(公告)日:2024-04-16
申请号:US17314254
申请日:2021-05-07
Applicant: Cambridge Enterprise Limited
Inventor: Emma Yates , Christopher Dobson , Therese Herling , Tuomas Pertti Jonathan Knowles
CPC classification number: G01N33/6845 , B01L3/502753 , G01N15/0266 , G01N27/447 , G01N33/50 , G01N33/52 , B01L2200/0631 , B01L2200/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0421 , G01N2015/0038 , G01N2015/0288
Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.
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公开(公告)号:US20210318330A1
公开(公告)日:2021-10-14
申请号:US17314254
申请日:2021-05-07
Applicant: Cambridge Enterprise Limited
Inventor: Emma Yates , Christopher Dobson , Therese Herling , Tuomas Pertti Jonathan Knowles
Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.
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公开(公告)号:US20180328831A1
公开(公告)日:2018-11-15
申请号:US15921778
申请日:2018-03-15
Applicant: Cambridge Enterprise Limited
Inventor: Samuel Cohen , Tuomas Knowles , Christopher Dobson , Luke Rajah , Duncan White
IPC: G01N13/00 , G01N33/487 , B01F5/06 , B01F5/04 , B01F13/00
CPC classification number: G01N13/00 , B01F5/045 , B01F5/0647 , B01F13/0093 , G01N33/487 , G01N2013/003
Abstract: Methods for determining the lateral diffusion of one or more components are provided.
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公开(公告)号:US20180306813A1
公开(公告)日:2018-10-25
申请号:US16068058
申请日:2016-12-28
Applicant: Cambridge Enterprise Limited
Inventor: Christopher Dobson , Tuomas Knowles , Michele Vendruscolo , Johnny Habchi , Sean Chia
IPC: G01N33/68 , G01N33/50 , G01N33/557
CPC classification number: G01N33/6896 , A61K38/00 , C07K14/4711 , G01N33/5058 , G01N33/557 , G01N2500/04
Abstract: The present invention relates to methods of identifying pharmacophores and inhibitors against protein aggregation. The present invention also provides pharmacophores themselves and medical uses of agents in the treatment of Alzheimer's.
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公开(公告)号:US11536729B2
公开(公告)日:2022-12-27
申请号:US16068058
申请日:2016-12-28
Applicant: Cambridge Enterprise Limited
Inventor: Christopher Dobson , Tuomas Knowles , Michele Vendruscolo , Johnny Habchi , Sean Chia
IPC: G01N33/68 , C07K14/47 , G01N33/50 , G01N33/557 , A61K38/00
Abstract: The subject matter disclosed herein relates to methods of identifying pharmacophores and inhibitors against protein aggregation. The present disclosure also provides pharmacophores themselves and medical uses of agents in the treatment of diseases associated with protein aggregation.
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