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    Fluidic device
    4.
    发明授权
    Fluidic device 有权

    公开(公告)号：US09958369B2

    公开(公告)日：2018-05-01

    申请号：US14438145

    申请日：2013-10-22

    Applicant: CAMBRIDGE ENTERPRISE LIMITED

    Inventor： Samuel Cohen ,  Tuomas Knowles ,  Christopher Dobson ,  Luke Rajah ,  Duncan White

    IPC: G01N13/00 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  G01N33/487

    CPC classification number: G01N13/00 ,  B01F5/045 ,  B01F5/0647 ,  B01F13/0093 ,  G01N33/487 ,  G01N2013/003

    Abstract: A method for determining the diffusion of one or more components, the method includes the steps of (i) providing a component fluid flow having one or more components; (ii) providing a blank fluid flow; (iii) bringing the flow (i) into contact with the flow (ii) in a large cross section channel, thereby to generate two laminar flows; (iv) permitting the laminar flows generated in (iii) to flow from the large cross section channel into a small cross section channel; measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow in the small cross section channel. Also provided is a diffusion method having the steps of measuring the lateral diffusion of the one or more components from the component flow into the blank fluid flow at a plurality of diffusion times.

    IMPROVEMENTS IN OR RELATING TO AN APPARATUS FOR CHARACTERISING A COMPONENT
    5.
    发明公开
    IMPROVEMENTS IN OR RELATING TO AN APPARATUS FOR CHARACTERISING A COMPONENT 审中-公开

    公开(公告)号：US20230204576A1

    公开(公告)日：2023-06-29

    申请号：US17926780

    申请日：2021-05-21

    Applicant: Fluidic Analytics Limited ,  Cambridge Enterprise Limited

    Inventor： Sean Devenish ,  Tuomas Knowles ,  Vasilis Kosmoliaptsis ,  Georg Meisl ,  Ashley Priddey ,  Tom Scheidt ,  Matthias Schneider ,  Catherine Xu

    IPC: G01N33/558 ,  G01N33/68

    CPC classification number: G01N33/558 ,  G01N33/6845

    Abstract: An apparatus for characterising a biomolecule is provided. The apparatus comprising a sample inlet channel configured to introduce a sample fluid including the biomolecule to the apparatus; an auxiliary inlet channel configured to introduce an auxiliary fluid to the apparatus; a distribution channel in fluid communication with the sample inlet channel and the auxiliary inlet channel; wherein the distribution channel is adapted to generate a distribution of biomolecules; a measurement module configured to detect a signature profile of the biomolecule to obtain a measured dataset of the detected biomolecule; a storage location configured to store and maintain a stored dataset comprising a plurality of parameters that are associated with the measured dataset obtained from the measurement module; and an analysis module configured to receive the stored dataset from the storage location and correlate the stored dataset with the measured dataset from the measurement module to provide a correlation value, wherein the analysis module is further configured to use the correlation value to determine at least two characteristics of the biomolecule simultaneously using Bayesian analysis. A method for characterising a biomolecule is also provided.

    Fluidic analysis and separation
    6.
    发明授权
    Fluidic analysis and separation 有权

    公开(公告)号：US10386332B2

    公开(公告)日：2019-08-20

    申请号：US15307221

    申请日：2015-04-30

    Applicant: CAMBRIDGE ENTERPRISE LIMITED

    Inventor： Therese Herling ,  Thomas Mueller ,  Tuomas Knowles

    IPC: G01N27/447 ,  B01L3/00 ,  G01N15/02

    Abstract: A method for analyzing a component is provided. The method includes the steps of: (iii) providing the electrophoretic or thermophoretic movement of the component into a second fluid flow; (iv) diverting a part of a first fluid flow, a part of the second fluid flow, or parts of the first fluid flow and the second fluid flow, wherein the diverted part is a third fluid flow which includes, the component; (v) contacting the third fluid flow with a fourth fluid flow, such as to form a laminar flow; (vi) providing the diffusion of the component into the fourth fluid flows.

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