公开(公告)号：US20230346550A1

公开(公告)日：2023-11-02

申请号：US18218419

申请日：2023-07-05

Applicant: CARDIOVALVE LTD.

Inventor： Yossi GROSS ,  Gil HACOHEN

IPC: A61F2/24 ,  A61B17/122

CPC classification number: A61F2/2418 ,  A61B17/122 ,  A61F2/2409 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2466 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/848

Abstract: A heart valve repair system includes a delivery sheath and an implant that includes a frame including a braided structure of intertwining strands and having a surface configured to contact an upstream surface of a native heart valve. First and second gripping members are coupled to the frame, each including atrial and ventricular arms. The implant is disposed in the sheath in a delivery state in which the frame defines a wall fully surrounding a central longitudinal axis of the implant. The distal end of the wall defines a distal opening of the frame. The distal end of the wall is disposed proximally to the second end of the ventricular arm of each of the gripping members. The second end of each ventricular arm moves toward the axis of the implant more than the first end moves toward the axis. Other embodiments are also described.

公开(公告)号：US20230058653A1

公开(公告)日：2023-02-23

申请号：US17982897

申请日：2022-11-08

Applicant: CARDIOVALVE LTD.

Inventor： Yossi GROSS ,  Gil HACOHEN

IPC: A61F2/24 ,  A61B17/122

Abstract: A heart valve repair system includes a delivery sheath and an implant that includes a frame having a surface configured to contact an upstream surface of a native heart valve. First and second gripping members are coupled to the frame and each (1) includes first and second arms and (2) is configured to clamp a respective native leaflet. The implant is disposed in the sheath in a delivery state in which the frame defines a wall fully surrounding a central longitudinal axis of the implant. The distal end of the wall defines a distal opening of the frame. The distal end of the wall is disposed proximally to the entire first tissue-engaging surface of each of the gripping members and proximally to the entire second tissue-engaging surface of each of the gripping members. Other embodiments are also described.

公开(公告)号：US20220378410A1

公开(公告)日：2022-12-01

申请号：US17875589

申请日：2022-07-28

Applicant: CARDIOVALVE LTD

Inventor： Gil HACOHEN ,  Yossi GROSS ,  Tal REICH

IPC: A61B17/04 ,  A61F2/24

Abstract: A transluminal sheath is advanced transseptally into a left atrium of the subject. A distal end of a surrounding-sheath, having an anchor disposed therein, is advanced via a distal end of the transluminal sheath, into a left ventricle of the subject via a commissure of the mitral valve. While the distal end of the surrounding-sheath is in the left ventricle, the surrounding-sheath is pulled proximally with respect to the anchor to expose the anchor. While the distal end of the surrounding-sheath is in the left ventricle, mitral valve tissue that is within the left ventricle is encircled by helically wrapping the anchor around the mitral valve tissue. Subsequently, the surrounding-sheath is extracted from the heart. Other embodiments are also described.

公开(公告)号：US20210338426A1

公开(公告)日：2021-11-04

申请号：US17335845

申请日：2021-06-01

Applicant: CARDIOVALVE LTD.

Inventor： Yossi GROSS ,  Gil HACOHEN

IPC: A61F2/24

Abstract: An implant is configured to be coupled to first and second native leaflets of a native heart valve of a patient. The implant includes a proximal collar, a distal collar, and first and second clasps. Each of the first and second clasps has first and second tissue-engaging portions that are (1) disposed distal to the proximal collar and proximal to the distal collar, and (2) movable, with respect to each other, to clamp one of the leaflets between the first and second tissue-engaging portions of the clasp. The implant is configured such that, when the leaflets are clamped by the first and second clasps, the first and second clasps form the first and second native leaflets into a double orifice, each orifice configured to function as a respective check-valve. Other embodiments are also described.

公开(公告)号：US20240058123A1

公开(公告)日：2024-02-22

申请号：US18385643

申请日：2023-10-31

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Yuval ZIPORY ,  Tal REICH ,  Yaron HERMAN ,  Gil HACOHEN ,  Eran MILLER ,  Rotem NEEMAN ,  Natalia KRUGLOVA

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2436 ,  A61F2/2418 ,  A61F2/2409 ,  A61F2220/0075 ,  A61F2250/0098 ,  A61F2220/0025 ,  A61F2220/0016 ,  A61F2210/0076

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US20210315698A1

公开(公告)日：2021-10-14

申请号：US17306231

申请日：2021-05-03

Applicant: CARDIOVALVE LTD.

Inventor： Yossi GROSS ,  Gil HACOHEN

IPC: A61F2/24

Abstract: An implant is configured to be coupled to first and second native leaflets of a native heart valve of a patient. The implant includes a proximal collar, a distal collar, and first and second clasps. Each of the first and second clasps has first and second tissue-engaging portions that are (1) disposed distal to the proximal collar and proximal to the distal collar, (2) movable, with respect to each other, to clamp one of the leaflets between the first and second tissue-engaging portions of the clasp, and (3) movable, when clamped to the leaflet, toward and away from a central longitudinal axis of the implant. Other embodiments are also described.

公开(公告)号：US20210307900A1

公开(公告)日：2021-10-07

申请号：US17210183

申请日：2021-03-23

Applicant: CARDIOVALVE LTD.

Inventor： Gil HACOHEN

IPC: A61F2/24

Abstract: An implant includes first and second clasps, each having first and second tissue-engaging portions which are movable with respect to each other to clamp one of the native heart valve leaflets between respective tissue-engaging surfaces. Each of the tissue-engaging portions has a surface opposite the respective tissue-engaging surface. For each clasp, the implant includes a respective leg portion and a respective intermediate portion. Each intermediate portion is (i) coupled to the opposite surface of the second tissue-engaging portion of the clasp such that an orientation of the intermediate portion is fixed with respect to an orientation of the opposite surface of the second tissue-engaging portion of the clasp, and (ii) coupled to the leg portion at a respective portion of the implant that allows movement of the leg portion with respect to the intermediate portion. Other embodiments are also described.

公开(公告)号：US20210169467A1

公开(公告)日：2021-06-10

申请号：US17181961

申请日：2021-02-22

Applicant: CARDIOVALVE LTD.

Inventor： Gil HACOHEN ,  Yossi GROSS ,  Tal REICH

IPC: A61B17/04 ,  A61F2/24

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular spacer configured for implantation with a native heart valve opening and a central valve section configured for disposal within the annular spacer. The central valve section may include at least one anchoring protrusion configured to anchor the central valve section against axial movement relative to the annular spacer. During deployment, the central valve section may be expanded radially within the heart into an at least partially-expanded configuration while at least a portion of the central valve section is situated outside of a space opening of the annular spacer, and moved upstream while remaining in the at least partially-expanded configuration until the anchoring protrusion engages the annular spacer.

公开(公告)号：US20200330221A1

公开(公告)日：2020-10-22

申请号：US16881350

申请日：2020-05-22

Applicant: CARDIOVALVE LTD.

Inventor： Gil HACOHEN

IPC: A61F2/24

Abstract: An implant includes a primary structural element, and two clips coupled to the primary structural element, on opposite lateral sides of the primary structural element from each other, each of the clips having a first clip element and a second clip element. The implant is transluminally advanced to a heart valve of a subject. The implant is coupled to leaflets of the valve (i) by, for each of the clips, closing the clip around a central part of a respective leaflet of the valve by causing deflection between the first clip element and the second clip element, thereby sandwiching the central part of the respective leaflet between the first clip element and the second clip element, and (ii) such that the leaflets form a double orifice configuration, with the primary structural element disposed between the central parts of the leaflets. Other embodiments are also described.

公开(公告)号：US20190015202A1

公开(公告)日：2019-01-17

申请号：US16138129

申请日：2018-09-21

Applicant: CARDIOVALVE LTD.

Inventor： Gil HACOHEN

IPC: A61F2/24 ,  A61B17/064 ,  A61B17/04 ,  A61B17/00

Abstract: A catheter is transluminally advanced to a heart of a subject. Via the catheter, a prosthetic valve is advanced to the native valve. The prosthetic valve includes an upstream skirt, and a downstream skirt that has a first portion and a second portion. The first portion defines a lumen therethrough. The second portion circumscribes the first portion, and defines a plurality of anchoring arms that are coupled to the second portion. A plurality of prosthetic leaflets, within the lumen, are attached to the first portion. The upstream skirt is expanded in the atrium, and the anchoring arms are expanded in the ventricle, the anchoring arms extending radially outward and toward the upstream skirt. Subsequently, native valve tissue is squeezed between the upstream skirt and the anchoring arms by causing the anchoring arms to move with respect to the prosthetic leaflets, and toward the upstream skirt.