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公开(公告)号:US09790233B2
公开(公告)日:2017-10-17
申请号:US14395021
申请日:2013-04-16
申请人: CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , University of Kentucky Research Foundation
发明人: Sanford Markowitz , James K. V. Willson , Bruce A. Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号: C07D495/04 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , C07C311/21
CPC分类号: C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号:US20150072998A1
公开(公告)日:2015-03-12
申请号:US14395021
申请日:2013-04-16
申请人: Case Western Reserve University , Board of Regents of the University of Texas System , University of Kentucky
发明人: Sanford Markowitz , James K.V. Willson , Bruce A. Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Melissa Moss , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号: C07D495/04
CPC分类号: C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
摘要翻译: 调节15-PGDH活性,调节组织前列腺素水平,治疗疾病,疾病障碍或期望调节15-PGDH活性和/或前列腺素水平的病症的化合物和方法包括描述的15-PGDH抑制剂和15-PGDH激活剂 这里。
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