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公开(公告)号：US09790233B2
公开(公告)日：2017-10-17
申请号：US14395021
申请日：2013-04-16
申请人： CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , University of Kentucky Research Foundation
发明人： Sanford Markowitz , James K. V. Willson , Bruce A. Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： C07D495/04 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , C07C311/21
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US20240043443A1
公开(公告)日：2024-02-08
申请号：US18228452
申请日：2023-07-31
申请人： CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monica Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： C07D495/04 , C07C311/21 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , A61K31/4365 , A61K31/519
CPC分类号： C07D495/04 , C07C311/21 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , A61K31/4365 , A61K31/519 , C07C2601/14
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US20170165241A1
公开(公告)日：2017-06-15
申请号：US15359330
申请日：2016-11-22
申请人： CASE WESTERN RESERVE UNIVERSITY , Board of Regents of the University of Texas System , University of Kentucky Research Foundation
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Youngyou Zhang , Hsin-Hsiung Tai , Melissa Moss , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： A61K31/4365 , A61K31/519
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US20210032265A1
公开(公告)日：2021-02-04
申请号：US16943932
申请日：2020-07-30
申请人： CASE WESTERN RESERVE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： C07D495/04 , C07C311/21 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , A61K31/4365 , A61K31/519
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US10301320B2
公开(公告)日：2019-05-28
申请号：US15359330
申请日：2016-11-22
申请人： CASE WESTERN RESERVE UNIVERSITY , Board of Regents of the University of Texas System , University of Kentucky Research Foundation
发明人： Sanford Markowitz , James K. V. Willson , Bruce Posner , Joseph Ready , Youngyou Zhang , Hsin-Hsiung Tai , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： A61K31/4365 , C07D495/04 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D405/12 , C07D239/42 , C07D241/20 , C07D261/14 , C07D207/263 , C07D275/03 , C07D209/08 , C07D277/46 , C07D295/185 , C07C311/21 , A61K31/519
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：US20150072998A1
公开(公告)日：2015-03-12
申请号：US14395021
申请日：2013-04-16
申请人： Case Western Reserve University , Board of Regents of the University of Texas System , University of Kentucky
发明人： Sanford Markowitz , James K.V. Willson , Bruce A. Posner , Joseph Ready , Yongyou Zhang , Hsin-Hsiung Tai , Melissa Moss , Monika Antczak , Stanton Gerson , KiBeom Bae , Sung Yeun Yang , Amar Desai
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
摘要翻译： 调节15-PGDH活性，调节组织前列腺素水平，治疗疾病，疾病障碍或期望调节15-PGDH活性和/或前列腺素水平的病症的化合物和方法包括描述的15-PGDH抑制剂和15-PGDH激活剂 这里。
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公开(公告)号：US11718589B2
公开(公告)日：2023-08-08
申请号：US16484045
申请日：2018-02-06
发明人： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04 , A61K45/06 , A61K31/4164
CPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/0006 , A61K31/4164 , A61K45/06
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20210106587A1
公开(公告)日：2021-04-15
申请号：US16997273
申请日：2020-08-19
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Monika Antczak , Yongyou Zhang , Amar Desai , Stanton Gerson , William Greenlee , Sung Yeun Yang , KiBeom Bae
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20180118756A1
公开(公告)日：2018-05-03
申请号：US15566637
申请日：2016-04-14
发明人： Sanford Markowitz , Joseph Ready , Yongyou Zhang , Monika Antczak , James K.V. Willson , Bruce Posner , William Greenlee
IPC分类号： C07D495/04 , A61K9/00 , A61Q19/04 , A61Q7/00 , A61P17/02 , A61P17/14 , A61P17/00 , A61P1/04 , A61P1/02 , A61P1/00 , A61P25/02 , A61P9/12 , A61P9/00 , A61P13/12 , A61P37/06 , A61P39/00 , A61P37/04 , A61P7/06 , A61P1/16 , A61P15/10 , A61P35/00 , A61P35/04 , A61K35/28 , A61P35/02 , A61P11/00 , A61P9/10 , A61P19/00 , A61P25/00 , A61P9/04 , A61P29/00 , A61P25/16 , A61K38/19 , A61K31/395 , A61K31/4365 , A61K31/444 , A61K31/519 , A61K31/4545 , A61K8/49
CPC分类号： C07D495/04 , A61K8/49 , A61K9/0014 , A61K9/0019 , A61K31/395 , A61K31/4365 , A61K31/444 , A61K31/4545 , A61K31/519 , A61K31/5377 , A61K35/28 , A61K38/193 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/10 , A61P17/00 , A61P17/02 , A61P17/14 , A61P19/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P29/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/04 , A61P37/06 , A61P39/00 , A61Q7/00 , A61Q19/04 , Y02A50/423 , A61K2300/00
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20230322684A1
公开(公告)日：2023-10-12
申请号：US18207777
申请日：2023-06-09
发明人： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04
CPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/0006 , A61K45/06
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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