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公开(公告)号：US10353130B2
公开(公告)日：2019-07-16
申请号：US15504825
申请日：2015-12-08
Applicant: Cellomics, Inc.
Abstract: An apparatus and method of delivering a precisely sized, homogeneous field of light within an optical system. The apparatus operates equally well over UV, visible, and NIR wavelengths, over a wide range of input beam divergence and regardless of heterogeneity. A tapered or contoured homogenizing rod that creates an evenly distributed illumination at a target area of specific size.
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公开(公告)号：US20190154652A1
公开(公告)日：2019-05-23
申请号：US16259072
申请日：2019-01-28
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G01N2201/0631 , G01N2201/064 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US20150323462A1
公开(公告)日：2015-11-12
申请号：US14709239
申请日：2015-05-11
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N21/64 , G01N33/487 , G02B5/02
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
Abstract translation: 对生物样品进行成像和使用发色团分析成像样品的系统和方法。 发色团分析可以自己完成，也可以与高分辨率成像系统中的荧光团分析相结合。 为了进行发色团分析，可以用不同的发色团标记生物样品，并使用至少部分被发色团吸收的透射光成像。 为了进行荧光团分析，样品也可以用被激发光激发的荧光团标记。 发色团分析和荧光团分析可以使用高分辨率成像系统单独或同时进行。 该系统通过用不同波长的透射光照射发色团标记的样品并自动检测表示样品对着色光的差分吸收的图像来提供扩展的能力。
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Patent Agency Ranking
公开(公告)号：US10393725B2
公开(公告)日：2019-08-27
申请号：US16259072
申请日：2019-01-28
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N33/487 , G01N21/64 , G02B5/02 , G01N21/31 , G01N21/25 , G02B21/36 , G02B21/16 , G01N35/00 , F21Y105/14 , F21Y105/10
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US20170248574A1
公开(公告)日：2017-08-31
申请号：US15594978
申请日：2017-05-15
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G01N2201/0631 , G01N2201/064 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US09683939B2
公开(公告)日：2017-06-20
申请号：US14709239
申请日：2015-05-11
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N21/25 , G01N21/64 , G02B5/02 , G01N33/487 , F21Y105/00
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US10234445B2
公开(公告)日：2019-03-19
申请号：US15594978
申请日：2017-05-15
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N33/487 , G01N21/64 , G02B5/02 , G01N21/25 , G01N21/31 , G01N35/00 , G02B21/16 , G02B21/36 , F21Y105/14 , F21Y105/10
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US20140194321A1
公开(公告)日：2014-07-10
申请号：US13734751
申请日：2013-01-04
Applicant: CELLOMICS, INC.
Inventor： Monica Jo Tomaszewski
IPC: C12Q1/02
CPC classification number: G01N33/5047 , G01N33/5029 , G16B99/00
Abstract: A method of predicting whether a compound is a skin sensitizer using an in vitro approach. The method includes a step of imaging immune effector cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of a compound. The method further includes a step of quantitatively measuring the imaged cellular targets over a range of concentrations of the compound to detect changes in multiple cellular targets of the immune effector cells associated with skin sensitivity. The method further includes a step of analyzing measurements obtained from the measured imaged cellular targets over the range of concentrations of the compound to determine whether the compound is a skin sensitizer.
Abstract translation: 使用体外方法预测化合物是否为皮肤敏化剂的方法。 该方法包括对位于多个容器内的免疫效应细胞进行成像以获得成像细胞靶的步骤，每个容器用不同浓度的化合物处理。 该方法还包括在化合物的浓度范围内定量测量成像的细胞靶标以检测与皮肤敏感性相关的免疫效应细胞的多个细胞靶的变化的步骤。 该方法还包括在化合物浓度范围内分析从测量的成像细胞靶标获得的测量值以确定化合物是皮肤敏化剂的步骤。
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