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公开(公告)号：US20140069419A1
公开(公告)日：2014-03-13
申请号：US13964298
申请日：2013-08-12
Applicant: Chiesi farmaceutici S.p.A.
Inventor： Eleonora GHIDINI
CPC classification number: C07J71/0068 , A61K31/58 , A61K45/06 , A61M11/00 , A61M15/0028
Abstract: Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.
Abstract translation: 作为异恶唑烷衍生物的糖皮质激素可用作糖皮质激素系列的抗炎和抗过敏化合物。
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Patent Agency Ranking
公开(公告)号：US20150057257A1
公开(公告)日：2015-02-26
申请号：US14537184
申请日：2014-11-10
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Eleonora GHIDINI , Andrea RIZZI
CPC classification number: C07J71/0068 , A61K31/58 , A61K45/06
Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.
Abstract translation: 根据本文定义的式（I）的式（I）的糖皮质激素系列的抗炎和抗过敏化合物可用于治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US20240425482A1
公开(公告)日：2024-12-26
申请号：US18702454
申请日：2022-10-17
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Laura CARZANIGA , Fabio RANCATI , Andrea RIZZI , Eleonora GHIDINI , Nicolò IOTTI , Roberta MAZZUCATO , Stefano LEVANTO , Ben Paul WHITTAKER
IPC: C07D401/14 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D487/10
Abstract: The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.
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公开(公告)号：US20150158858A1
公开(公告)日：2015-06-11
申请号：US14560140
申请日：2014-12-04
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Gabriele AMARI , Elisabetta ARMANI , Eleonora GHIDINI , Charles BAKER-GLENN , Hervé VAN DE POËL , Ben WHITTAKER
IPC: C07D453/02 , C07D409/14 , A61M15/00 , A61K31/4545 , A61K31/4436 , A61M16/14 , A61K31/444 , A61K31/4439
CPC classification number: C07D453/02 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61M15/0065 , A61M16/14 , A61M2202/064 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Compounds of formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
Abstract translation: 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US20180066010A1
公开(公告)日：2018-03-08
申请号：US15807066
申请日：2017-11-08
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Eleonora GHIDINI , Andrea Rizzi
CPC classification number: C07J71/0068 , A61K31/58 , A61K45/06
Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.
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公开(公告)号：US20150376226A1
公开(公告)日：2015-12-31
申请号：US14844156
申请日：2015-09-03
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Eleonora GHIDINI
CPC classification number: C07J71/0068 , A61K31/58 , A61K45/06 , A61M11/00 , A61M15/0028
Abstract: Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.
Abstract translation: 作为异恶唑烷衍生物的糖皮质激素可用作糖皮质激素系列的抗炎和抗过敏化合物。
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