公开(公告)号：US09999678B2

公开(公告)日：2018-06-19

申请号：US14647626

申请日：2013-11-26

申请人： Contipro Biotech s.r.o.

发明人： Daniela Smejkalova ,  Gloria Huerta-Angeles ,  Martin Bobek ,  Martina Hermannova ,  Lucie Vistejnova ,  Jaroslav Novotny ,  Eva Prikopova ,  Kristina Nesporova ,  Miroslava Nemcova ,  Klara Slezingrova ,  Jaromir Kulhanek ,  Dagmar Cozikova ,  Jana Sogorkova ,  Jan Kucera ,  Pavel Klein ,  Vladimir Velebny

IPC分类号： A61K31/728 ,  C08B37/08 ,  A61K47/48 ,  A61K31/355 ,  A61K31/337 ,  A61K31/685 ,  A61K31/122 ,  C08K3/30 ,  A61K8/02 ,  A61K8/73 ,  A61Q19/00 ,  A61K47/36 ,  A61K9/107 ,  A61K47/69 ,  A61K36/00

CPC分类号： A61K47/61 ,  A61K8/0291 ,  A61K8/735 ,  A61K9/1075 ,  A61K31/122 ,  A61K31/337 ,  A61K31/355 ,  A61K31/685 ,  A61K36/00 ,  A61K47/36 ,  A61K47/6907 ,  A61K2800/10 ,  A61K2800/413 ,  A61K2800/56 ,  A61Q19/00 ,  C08B37/0072 ,  C08K3/30 ,  C08K2003/3045

摘要： The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronan derivatives are usable in cosmetic and pharmaceutical applications.

公开(公告)号：US20150308016A1

公开(公告)日：2015-10-29

申请号：US14647649

申请日：2013-11-26

申请人： CONTIPRO BIOTECH S.R.O.

发明人： Jolana Scudlova ,  Jiri Betak ,  Lucie Wolfova ,  Radovan Buffa ,  Klara Slezingrova ,  Pavel Klein ,  Ilona Matejkova ,  Martin Bobek ,  Tomas Pitucha ,  Vladimir Velebny ,  Romana Sulakova

IPC分类号： D01D5/06 ,  D01D10/06 ,  A61L31/14 ,  D01F9/00 ,  A61L31/04

CPC分类号： D01D5/06 ,  A61L27/20 ,  A61L27/56 ,  A61L31/042 ,  A61L31/14 ,  C08B37/0072 ,  D01D10/06 ,  D01F9/00 ,  D10B2401/02 ,  D10B2401/063 ,  D10B2401/12 ,  D10B2509/00 ,  C08L5/08

摘要： The invention relates to the biodegradable fibres which are based on hydrophobic derivatives of hylauronan, specifically on the base of the hyaluronan derivative C11-C18-acylated on hydroxyl groups of hyaluronic acid, and use thereof. Further the invention relates to the preparation of these fibres which is performed with the use of the wet spinning method in a coagulation bath comprising water solution of organic acid, with the production of continuous monofiles which can be thereafter processed to threads and further to textiles, knitted textiles, or nonwoven textiles. These textiles, knitted textiles or nonwoven textiles can be used for example for the production of implantable surgical material for human and veterinary medicine.

摘要翻译： 本发明涉及基于hylauronan的疏水性衍生物的生物可降解纤维，特别是在透明质酸的羟基上酰基化的透明质酸衍生物C11-C18的碱基及其应用。 此外，本发明涉及这些纤维的制备，其通过使用湿纺丝法在包含有机酸的水溶液的凝固浴中进行，同时制备连续的单丝，然后可以将其加工成螺纹并进一步纺织， 针织纺织品或非织造布纺织品。 这些纺织品，针织纺织品或非织造织物可以用于例如生产用于人和兽医学的可植入手术材料。

公开(公告)号：US20150320873A1

公开(公告)日：2015-11-12

申请号：US14647626

申请日：2013-11-26

申请人： CONTIPRO BIOTECH S.R.O

发明人： Daniela Smejkalova ,  Gloria Huerta-Angeles ,  Martin Bobek ,  Martina Hermannova ,  Lucie Vistejnova ,  Jaroslav Novotny ,  Eva Prikopova ,  Kristina Nesporova ,  Miroslava Nemcova ,  Klara Slezingrova ,  Jaromir Kulhanek ,  Dagmar Cozikova ,  Jana Sogorkova ,  Jan Kucera ,  Pavel Klein ,  Vladimir Velebny

IPC分类号： A61K47/48 ,  A61K31/355 ,  A61K31/337 ,  A61K31/685 ,  A61Q19/00 ,  A61K36/185 ,  C08K3/30 ,  C08J3/24 ,  A61K8/02 ,  A61K8/73 ,  C08B37/08 ,  A61K31/122

CPC分类号： A61K47/61 ,  A61K8/0291 ,  A61K8/735 ,  A61K9/1075 ,  A61K31/122 ,  A61K31/337 ,  A61K31/355 ,  A61K31/685 ,  A61K36/00 ,  A61K47/36 ,  A61K47/6907 ,  A61K2800/10 ,  A61K2800/413 ,  A61K2800/56 ,  A61Q19/00 ,  C08B37/0072 ,  C08K3/30 ,  C08K2003/3045

摘要： The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronan derivatives are usable in cosmetic and pharmaceutical applications.

摘要翻译： 本发明涉及一种制备疏水化透明质酸（式I）的方法，还涉及一种将生物活性物质包封在作为生物活性疏水物质的载体的疏水化透明质酸的纳米胶囊中的方法。 透明质酸的疏水化通过透明质酸与长链羧酸的酯化反应进行，后者由2,4,6-三氯苯甲酸的卤化物衍生物或另一种有机氯化物活化。 在水性环境中，水溶性疏水化衍生物可以形成纳米胶束，其中非极性物质可以通过非共价物理相互作用结合。 纳米胶束的核心由疏水性酰基官能团形成，而纳米胶束的壳由透明质酸形成。 可以通过溶剂交换法或通过超声处理将物质包封在纳米胶束中。 透明质酸纳米胶囊支持局部应用中结合物质的渗透，并使结合物质转移到单个细胞中。 从疏水化透明质酸衍生物获得的纳米胶囊可用于化妆品和药物应用。