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公开(公告)号：US20220364032A1
公开(公告)日：2022-11-17
申请号：US17869419
申请日：2022-07-20
申请人： CORNING INCORPORATED
摘要： A cell culture matrix for a perfusion-flow fixed-bed reactor is provided. The cell culture matrix includes a substrate having a porous sheet for adhering cells thereto. The sheet has a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate, arrayed in a regular pattern, and passing through the thickness of the substrate. The porous sheet is wound into a cylindrical shape having a plurality of wound layers, and the cell culture matrix does not include a spacer material or physical barrier between the plurality of wound layers of the substrate.
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公开(公告)号：US12037572B2
公开(公告)日：2024-07-16
申请号：US18206501
申请日：2023-06-06
申请人： CORNING INCORPORATED
CPC分类号： C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12M25/02 , C12N5/0068 , C12N5/0602 , C12N2513/00 , C12N2533/30 , C12N2533/40 , C12N2533/90 , C12N2535/00
摘要： A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
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公开(公告)号：US20240228940A1
公开(公告)日：2024-07-11
申请号：US18573720
申请日：2022-06-09
申请人： CORNING INCORPORATED
摘要： A bioreactor system for culturing cells is provided. The system includes a cell culture vessel with an interior reservoir. an inlet and an outlet fluidly connected to the reservoir. A fluid flow path supplies fluid to the inlet and receives fluid from the outlet. and a media conditioning vessel is fluidly connected to the cell culture vessel. The system also includes an outlet sensor arranged at the outlet of the cell culture vessel. The outlet sensor can detect a property of cell culture media exiting the cell culture vessel via the outlet, and the bioreactor system can adjust a property of the cell culture media based on the property detected by the outlet sensor.
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公开(公告)号：US20230348833A1
公开(公告)日：2023-11-02
申请号：US18206501
申请日：2023-06-06
申请人： CORNING INCORPORATED
CPC分类号： C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12N5/0068
摘要： A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
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公开(公告)号：US20240336883A1
公开(公告)日：2024-10-10
申请号：US18746891
申请日：2024-06-18
申请人： CORNING INCORPORATED
CPC分类号： C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12M25/02 , C12N5/0068 , C12N5/0602 , C12N2513/00 , C12N2533/30 , C12N2533/40 , C12N2533/90 , C12N2535/00
摘要： A cell culture matrix is provided that has a substrate with a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate and passing through the thickness of the substrate. The plurality of openings allow flow of at least one of cell culture media, cells, or cell products through the thickness of the substrate, and provides a uniform, efficient, and scalable matrix for cell seeding, proliferation, and culturing. The substrate can be formed from a woven polymer mesh material that provides a high surface area to volume ratio for cells and good fluid flow through the matrix. Bioreactor systems incorporating the cell culture matrix and related methods are also provided.
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公开(公告)号：US20240254421A1
公开(公告)日：2024-08-01
申请号：US18289446
申请日：2022-05-02
申请人： CORNING INCORPORATED
摘要： A fixed-bed bioreactor system (300) is provided that includes a vessel with a media inlet (310), a media outlet (312), and an interior cavity disposed between and in fluid communication with the media inlet and media outlet; a cell culture substrate disposed in the interior cavity between the media inlet and the media outlet in a packed-bed configuration, the cell culture substrate having a plurality of porous disks (308) in a stacked arrangement; and a harvesting volume (2010,2020) to hold a fluid, the harvesting volume being in fluid communication with the interior cavity, wherein each of the plurality of porous disks comprises a surface configured to culture cells thereon. The harvesting volume can be inside or outside of the vessel.
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公开(公告)号：US20240240128A1
公开(公告)日：2024-07-18
申请号：US18586065
申请日：2024-02-23
申请人： CORNING INCORPORATED
CPC分类号： C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12M25/02 , C12N5/0068 , C12N5/0602 , C12N2513/00 , C12N2533/30 , C12N2533/40 , C12N2533/90 , C12N2535/00
摘要： A cell culture matrix for a perfusion-flow fixed-bed reactor is provided. The cell culture matrix includes a substrate having a porous sheet for adhering cells thereto. The sheet has a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate, arrayed in a regular pattern, and passing through the thickness of the substrate. The porous sheet is wound into a cylindrical shape having a plurality of wound layers, and the cell culture matrix does not include a spacer material or physical barrier between the plurality of wound layers of the substrate.
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公开(公告)号：US11920117B2
公开(公告)日：2024-03-05
申请号：US17869419
申请日：2022-07-20
申请人： CORNING INCORPORATED
CPC分类号： C12M25/14 , C12M23/02 , C12M23/20 , C12M23/44 , C12M25/04 , C12M29/10 , C12M29/26 , C12M41/26 , C12M25/02 , C12N5/0068 , C12N5/0602 , C12N2513/00 , C12N2533/30 , C12N2533/40 , C12N2533/90 , C12N2535/00
摘要： A cell culture matrix for a perfusion-flow fixed-bed reactor is provided. The cell culture matrix includes a substrate having a porous sheet for adhering cells thereto. The sheet has a first side, a second side opposite the first side, a thickness separating the first side and the second side, and a plurality of openings formed in the substrate, arrayed in a regular pattern, and passing through the thickness of the substrate. The porous sheet is wound into a cylindrical shape having a plurality of wound layers, and the cell culture matrix does not include a spacer material or physical barrier between the plurality of wound layers of the substrate.
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