MEDICAL DEVICES HAVING SOFT, FLEXIBLE LUBRICIOUS COATINGS
    1.
    发明申请
    MEDICAL DEVICES HAVING SOFT, FLEXIBLE LUBRICIOUS COATINGS 有权
    具有柔软,柔性润滑涂层的医疗器械

    公开(公告)号:US20120041554A1

    公开(公告)日:2012-02-16

    申请号:US13282239

    申请日:2011-10-26

    IPC分类号: A61F2/16 A61F9/00

    摘要: Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.

    摘要翻译: 提供用于聚合物IOL插入盒的柔软,柔性高润滑性涂层,其允许IOL容易地插入适于与小(小于3mm)切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛,而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说,使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络(IPN)。 因此,IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。

    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses
    3.
    发明授权
    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses 有权
    用于制造前房人工晶状体的生物相容性聚合物组合物

    公开(公告)号:US07247689B2

    公开(公告)日:2007-07-24

    申请号:US11219021

    申请日:2005-09-01

    摘要: Biocompatible polymers useful for making anterior chamber intraocular lenses (AC-IOL) are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violet light absorbing dyes. The AC-IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia and astigmatisms.

    摘要翻译: 提供了可用于制备前房人工晶状体(AC-IOL)的生物相容性聚合物。 生物相容性聚合物通常由一种或多种丙烯酸酯单体组成,与至少一种二丙烯酸酯交联,并且可以包括一种或多种另外的组分,例如紫外光和/或蓝紫色光吸收染料。 使用本文公开的生物相容性聚合物制备的AC-IOL适于放置在晶状体或无晶状体眼睛中,并且用于屈光矫正,包括近视,远视,老花眼和散光。

    Medical devices having soft, flexible lubricious coatings
    4.
    发明授权
    Medical devices having soft, flexible lubricious coatings 有权
    具有软,柔性润滑涂层的医疗设备

    公开(公告)号:US08053078B2

    公开(公告)日:2011-11-08

    申请号:US11104321

    申请日:2005-04-11

    IPC分类号: A61F9/00

    摘要: Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.

    摘要翻译: 提供用于聚合物IOL插入盒的柔软,柔性高润滑性涂层,其允许IOL容易地插入适于与小(小于3mm)切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛,而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说,使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络(IPN)。 因此,IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。

    IOL insertion apparatus and methods for making and using same
    6.
    发明授权
    IOL insertion apparatus and methods for making and using same 有权
    IOL插入装置及其制造和使用方法

    公开(公告)号:US07687097B2

    公开(公告)日:2010-03-30

    申请号:US11146983

    申请日:2005-06-07

    摘要: Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.

    摘要翻译: 公开了用于插入眼内透镜(IOL)的装置和制造和使用装置的方法。 该装置包括具有限定中空空间的内壁的中空管,眼内透镜可以通过该中空空间从开放空间传入眼睛。 润滑性增强组分以有效促进眼内透镜通过中空空间的量在内壁处共价结合到中空管。 润滑性增强组分包括相对于没有取代基组分的相同润滑性增强组分有效减少所述润滑性增强组分的水解的取代基组分。

    POLYMER COMPOSITIONS SUITABLE FOR INTRAOCULAR LENSES AND RELATED METHODS
    7.
    发明申请
    POLYMER COMPOSITIONS SUITABLE FOR INTRAOCULAR LENSES AND RELATED METHODS 有权
    适用于内镜的聚合物组合物及相关方法

    公开(公告)号:US20090088839A1

    公开(公告)日:2009-04-02

    申请号:US11864450

    申请日:2007-09-28

    IPC分类号: A61F2/16 C08G77/04

    摘要: A polymeric material with a molecular response time that makes it suitable for use near fragile body tissues. The polymeric material is useful for both low modulus and high modulus applications thereby simplifying the multi-part polymeric article manufacturing process and creating better integrated multi-part polymeric articles. Cross-linked polymers with different moduli may be obtained utilizing the same or similar starting materials but modifying the amount of catalyst, the amount of cross-linking agent, and/or the amount of methyl vinyl cyclics.

    摘要翻译: 具有分子响应时间的聚合材料,使其适合在脆弱的身体组织附近使用。 聚合物材料可用于低模量和高模量应用,从而简化了多部件聚合物制品的制造过程,并且形成了更好的集成的多部分聚合物制品。 具有不同模量的交联聚合物可以利用相同或相似的起始材料获得,但改变催化剂的量,交联剂的量和/或甲基乙烯基环状的量。

    POLYMER COMPOSITIONS SUITABLE FOR INTRAOCULAR LENSES AND RELATED METHODS
    9.
    发明申请
    POLYMER COMPOSITIONS SUITABLE FOR INTRAOCULAR LENSES AND RELATED METHODS 有权
    适用于内镜的聚合物组合物及相关方法

    公开(公告)号:US20120186718A1

    公开(公告)日:2012-07-26

    申请号:US13432791

    申请日:2012-03-28

    IPC分类号: B32B37/14

    摘要: A polymeric material with a molecular response time that makes it suitable for use near fragile body tissues. The polymeric material is useful for both low modulus and high modulus applications thereby simplifying the multi-part polymeric article manufacturing process and creating better integrated multi-part polymeric articles. Cross-linked polymers with different moduli may be obtained utilizing the same or similar starting materials but modifying the amount of catalyst, the amount of cross-linking agent, and/or the amount of methyl vinyl cyclics.

    摘要翻译: 具有分子响应时间的聚合材料,使其适合在脆弱的身体组织附近使用。 聚合物材料可用于低模量和高模量应用,从而简化了多部件聚合物制品的制造过程,并且形成了更好的集成的多部分聚合物制品。 具有不同模量的交联聚合物可以利用相同或相似的起始材料获得,但改变催化剂的量,交联剂的量和/或甲基乙烯基环状的量。

    Polymer compositions suitable for intraocular lenses and related methods
    10.
    发明授权
    Polymer compositions suitable for intraocular lenses and related methods 有权
    适用于眼内透镜的聚合物组合物及相关方法

    公开(公告)号:US08216310B2

    公开(公告)日:2012-07-10

    申请号:US11864450

    申请日:2007-09-28

    IPC分类号: A61F2/16

    摘要: A polymeric material with a molecular response time that makes it suitable for use near fragile body tissues. The polymeric material is useful for both low modulus and high modulus applications thereby simplifying the multi-part polymeric article manufacturing process and creating better integrated multi-part polymeric articles. Cross-linked polymers with different moduli may be obtained utilizing the same or similar starting materials but modifying the amount of catalyst, the amount of cross-linking agent, and/or the amount of methyl vinyl cyclics.

    摘要翻译: 具有分子响应时间的聚合材料,使其适合在脆弱的身体组织附近使用。 聚合物材料可用于低模量和高模量应用,从而简化了多部件聚合物制品的制造过程,并且形成了更好的集成的多部分聚合物制品。 具有不同模量的交联聚合物可以利用相同或相似的起始材料获得,但改变催化剂的量,交联剂的量和/或甲基乙烯基环状的量。