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    MEDICAL DEVICES HAVING SOFT, FLEXIBLE LUBRICIOUS COATINGS
    1.
    发明申请
    MEDICAL DEVICES HAVING SOFT, FLEXIBLE LUBRICIOUS COATINGS 有权
    具有柔软，柔性润滑涂层的医疗器械

    公开(公告)号：US20120041554A1

    公开(公告)日：2012-02-16

    申请号：US13282239

    申请日：2011-10-26

    申请人： Can B. HU ,  Michael D. Lowery ,  Harish C. Makker

    发明人： Can B. HU ,  Michael D. Lowery ,  Harish C. Makker

    IPC分类号： A61F2/16 ,  A61F9/00

    CPC分类号： A61F2/1675 ,  A61L27/34 ,  C08G18/0823 ,  C08G18/833 ,  C08L39/06 ,  C09D175/04 ,  Y10T428/31536 ,  Y10T428/31551 ,  Y10T428/31663 ,  C08L5/08 ,  C08L2666/04

    摘要： Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.

    摘要翻译： 提供用于聚合物IOL插入盒的柔软，柔性高润滑性涂层，其允许IOL容易地插入适于与小（小于3mm）切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛，而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说，使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络（IPN）。 因此，IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。

    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses
    3.
    发明授权
    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses 有权
    用于制造前房人工晶状体的生物相容性聚合物组合物

    公开(公告)号：US07247689B2

    公开(公告)日：2007-07-24

    申请号：US11219021

    申请日：2005-09-01

    申请人： Harish C. Makker ,  Michael D. Lowery ,  Can B. Hu

    发明人： Harish C. Makker ,  Michael D. Lowery ,  Can B. Hu

    IPC分类号： C08F120/22 ,  C08F20/22 ,  C08F220/22 ,  C08F18/20

    CPC分类号： A61L27/26 ,  A61L2430/16 ,  C08F220/18

    摘要： Biocompatible polymers useful for making anterior chamber intraocular lenses (AC-IOL) are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violet light absorbing dyes. The AC-IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia and astigmatisms.

    摘要翻译： 提供了可用于制备前房人工晶状体（AC-IOL）的生物相容性聚合物。 生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外光和/或蓝紫色光吸收染料。 使用本文公开的生物相容性聚合物制备的AC-IOL适于放置在晶状体或无晶状体眼睛中，并且用于屈光矫正，包括近视，远视，老花眼和散光。

    Medical devices having soft, flexible lubricious coatings
    4.
    发明授权
    Medical devices having soft, flexible lubricious coatings 有权
    具有软，柔性润滑涂层的医疗设备

    公开(公告)号：US08053078B2

    公开(公告)日：2011-11-08

    申请号：US11104321

    申请日：2005-04-11

    申请人： Can B. Hu ,  Michael D. Lowery ,  Harish C. Makker

    发明人： Can B. Hu ,  Michael D. Lowery ,  Harish C. Makker

    IPC分类号： A61F9/00

    CPC分类号： A61F2/1675 ,  A61L27/34 ,  C08G18/0823 ,  C08G18/833 ,  C08L39/06 ,  C09D175/04 ,  Y10T428/31536 ,  Y10T428/31551 ,  Y10T428/31663 ,  C08L5/08 ,  C08L2666/04

    摘要： Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.

    摘要翻译： 提供用于聚合物IOL插入盒的柔软，柔性高润滑性涂层，其允许IOL容易地插入适于与小（小于3mm）切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛，而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说，使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络（IPN）。 因此，IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。

    Intraocular lens insertion apparatus
    6.
    发明授权
    Intraocular lens insertion apparatus 有权
    人工晶状体插入装置

    公开(公告)号：US06923815B2

    公开(公告)日：2005-08-02

    申请号：US10145233

    申请日：2002-05-14

    申请人： Daniel G. Brady ,  Harish C. Makker

    发明人： Daniel G. Brady ,  Harish C. Makker

    IPC分类号： A61F2/16 ,  A61F9/00

    CPC分类号： A61F2/1678

    摘要： An intraocular lens (IOL) insertion system for implanting IOLs into the eye. The insertion system includes an insertion cartridge that receives the IOL and cooperates with a handpiece. The cartridge includes a longitudinal lumen from a loading chamber to an open distal mouth that gradually narrows in dimension so as to fold the IOL into a tube for insertion through an incision in the eye. A distal tip member of a plunger rod in the handpiece enters the loading chamber of the cartridge and urges the IOL therethrough. The distal tip member has a portion that enters the folded IOL and is trapped therein for maximum control of IOL advancement. A soft tip, such as silicone, may cover a longitudinally extending portion of the distal tip to effect the IOL trapping. The distal tip member further has a portion that engages and pushes the IOL optic. The pusher portion not only ensures positive advancement of the IOL, but also limits the extent to which the distal tip member becomes trapped inside the folded IOL, thus preventing potential damage thereto.

    摘要翻译： 用于将IOL植入眼睛的人工晶状体（IOL）插入系统。 插入系统包括接收IOL并与手持件配合的插入盒。 药筒包括从装载室到开放的远端口的纵向内腔，其逐渐变窄的尺寸，以便将IOL折叠成用于通过眼睛中的切口插入的管。 手柄中的柱塞杆的远端部件进入筒的装载室并且通过其推动IOL。 远侧末端构件具有进入折叠的IOL并被捕获在其中的部分，以最大限度地控制IOL前进。 诸如硅树脂之类的软尖端可以覆盖远侧末端的纵向延伸部分以实现IOL捕获。 远侧末端构件还具有接合和推动IOL光学元件的部分。 推动器部分不仅确保了IOL的积极进展，而且限制了远侧末端构件被夹在折叠IOL内的程度，从而防止对其的潜在损害。

    Intraocular lenses made from polymeric compositions and monomers useful in said compositions
    8.
    再颁专利
    Intraocular lenses made from polymeric compositions and monomers useful in said compositions 有权
    由用于所述组合物的聚合物组合物和单体制成的人工晶状体

    公开(公告)号：USRE38935E1

    公开(公告)日：2006-01-10

    申请号：US10161806

    申请日：2002-06-04

    申请人： Harish C. Makker ,  Xiugao Liao ,  Joseph I. Weinschenk, III

    发明人： Harish C. Makker ,  Xiugao Liao ,  Joseph I. Weinschenk, III

    IPC分类号： A61F2/14

    CPC分类号： G02B1/043 ,  A61L27/16 ,  A61L2430/16 ,  C08L33/06

    摘要： Ophthalmic lenses, such as intraocular lenses, include crosslinked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of 2-phenylpropyl acrylate or methacrylate and mixtures thereof, and a second constituent derived from a second component in an amount effective as a crosslinker in the crosslinked polymeric material. The crosslinked polymeric material has branched chain alkyl groups, in an amount effective to reduce the tackiness of the crosslinked polymeric material relative to a substantially identical crosslinked polymeric material without branched chain alkyl groups.

    摘要翻译： 眼用透镜如眼内透镜包括具有衍生自第一单体组分的第一组分的交联聚合物材料，所述第一组分选自丙烯酸2-苯基丙酯或其混合物，和由第二组分衍生的第二组分 作为交联聚合物材料中的交联剂有效。 交联的聚合物材料具有支链烷基，其量可以有效地降低交联聚合物材料相对于没有支链烷基基本上相同的交联聚合物材料的粘性。

    IOL insertion apparatus and method for using same
    9.
    发明授权
    IOL insertion apparatus and method for using same 有权
    IOL插入装置及其使用方法

    公开(公告)号：US06254607B1

    公开(公告)日：2001-07-03

    申请号：US09392066

    申请日：1999-09-08

    申请人： Harish C. Makker ,  Shih-Liang S. Yang ,  Daniel G. Brady

    发明人： Harish C. Makker ,  Shih-Liang S. Yang ,  Daniel G. Brady

    IPC分类号： A61F900

    CPC分类号： A61F2/167 ,  A61F2/1678

    摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes comprises a tube, a rod having a distal end portion, and a tip carried by the distal end portion. The tip is softer than the distal end portion of the rod. Methods for inserting an IOL into an eye using such apparatus are within the scope of the present invention.

    摘要翻译： 将眼内透镜（IOL）插入到眼睛中的装置包括管，具有远端部的杆和由远端部承载的尖端。 尖端比杆的远端部分更软。 使用这种装置将IOL插入眼睛的方法在本发明的范围内。

    Intraocular lenses made from polymeric compositions and monomers useful in said compositions
    10.
    发明授权
    Intraocular lenses made from polymeric compositions and monomers useful in said compositions 有权
    由用于所述组合物的聚合物组合物和单体制成的人工晶状体

    公开(公告)号：US06245106B1

    公开(公告)日：2001-06-12

    申请号：US09286356

    申请日：1999-04-05

    申请人： Harish C. Makker ,  Xiugao Liao ,  Joseph I. Weinschenk, III

    发明人： Harish C. Makker ,  Xiugao Liao ,  Joseph I. Weinschenk, III

    IPC分类号： A61F214

    CPC分类号： G02B1/043 ,  A61L27/16 ,  A61L2430/16 ,  C08L33/06

    摘要： Ophthalmic lenses, such as intraocular lenses, include crosslinked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of 2-phenylpropyl acrylate or methacrylate and mixtures thereof, and a second constituent derived from a second component in an amount effective as a crosslinker in the crosslinked polymeric material. The crosslinked polymeric material has branched chain alkyl groups, in an amount effective to reduce the tackiness of the crosslinked polymeric material relative to a substantially identical crosslinked polymeric material without branched chain alkyl groups.

    摘要翻译： 眼用透镜如眼内透镜包括具有衍生自第一单体组分的第一组分的交联聚合物材料，所述第一组分选自丙烯酸2-苯基丙酯或其混合物，和由第二组分衍生的第二组分 作为交联聚合物材料中的交联剂有效。 交联的聚合物材料具有支链烷基，其量可以有效地降低交联聚合物材料相对于没有支链烷基基本上相同的交联聚合物材料的粘性。