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公开(公告)号：US4328315A
公开(公告)日：1982-05-04
申请号：US184700
申请日：1980-09-08
CPC分类号： C12R1/32 , C07J1/0011 , C12P33/005 , C12R1/33 , Y10S435/863 , Y10S435/865
摘要： Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
摘要翻译： 用于新型微生物过程中的选择性降解具有2至10个碳原子的17个烷基侧链的甾体至雄甾-1,4-二烯-3,17-二酮（ADD）和雄甾-4 - 烯-3,17-二酮（AD）。 ADD和AD是有用的类固醇的有价值的中间体。
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2.发明授权Process for preparing androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione 失效雄甾-1,4-二烯-3,17-二酮和雄甾-4-烯-3,17-二酮的制备方法
公开(公告)号：US4293645A
公开(公告)日：1981-10-06
申请号：US849526
申请日：1977-11-09
CPC分类号： C12R1/32 , C07J1/0011 , C12P33/005 , C12R1/33 , Y10S435/863 , Y10S435/865
摘要： Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
摘要翻译： 用于新型微生物过程中的选择性降解具有2至10个碳原子的17个烷基侧链的甾体至雄甾-1,4-二烯-3,17-二酮（ADD）和雄甾-4 - 烯-3,17-二酮（AD）。 ADD和AD是有用的类固醇的有价值的中间体。
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公开(公告)号：US4211841A
公开(公告)日：1980-07-08
申请号：US961964
申请日：1978-11-20
摘要： Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propionic acid]-7a.beta.-methylhexahydro-1,5-indanedione having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
摘要翻译： 将具有或不具有2至10个碳原子的17-烷基侧链的甾族化合物选择性转化为3aα-H-4α-[3'-丙酸]-7αβ-甲基六氢-1的新型微生物转化方法， 具有以下结构的5-茚满二酮：该化合物可用作中间体以制备有用的19-或类固醇。
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公开(公告)号：US4345033A
公开(公告)日：1982-08-17
申请号：US184723
申请日：1980-09-08
CPC分类号： C12R1/33 , C07J1/0011 , C12P33/00 , C12P33/005 , Y10S435/865
摘要： Mutant which is used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to yield predominantly androst-4-ene-3,17-dione (AD) and small amounts of androsta-1,4-diene-3,17-dione (ADD). AD is a valuable intermediate to make useful steroids.
摘要翻译： 用于新型微生物过程中的选择性降解具有2至10个碳原子的17个烷基侧链的类固醇的突变体，主要产生雄甾-4-烯-3,17-二酮（AD）和少量 雄甾-1,4-二烯-3,17-二酮（ADD）。 AD是有用的类固醇的有价值的中间体。
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公开(公告)号：US4339539A
公开(公告)日：1982-07-13
申请号：US184696
申请日：1980-09-08
CPC分类号： C12R1/32 , C07J1/0011 , C12P33/005 , C12R1/33 , Y10S435/863 , Y10S435/865
摘要： Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
摘要翻译： 用于新型微生物过程中的选择性降解具有2至10个碳原子的17个烷基侧链的甾体至雄甾-1,4-二烯-3,17-二酮（ADD）和雄甾-4 - 烯-3,17-二酮（AD）。 ADD和AD是有用的类固醇的有价值的中间体。
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公开(公告)号：US4062729A
公开(公告)日：1977-12-13
申请号：US745113
申请日：1976-11-26
CPC分类号： C12R1/33 , C07D311/94 , C12P17/04 , C12P7/26 , C12P7/40 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/868 , Y10S435/872 , Y10S435/88 , Y10S435/886 , Y10S435/939
摘要： Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-[3'-propionic acid]-7a.beta.-methylhexahydro-1,5-indanedione having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
摘要翻译： 将具有或不具有2至10个碳原子的17-烷基侧链的甾族化合物选择性转化为3aα-H-4α-[3'-丙酸]-7αβ-甲基六氢-1的新型微生物转化方法， 具有以下结构的5-茚满二酮：该化合物可用作中间体以制备有用的19-或类固醇。
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7.发明授权Mycobacterium phlei mutants convert sterols to androsta-1,4-diene-3,17-dione and androsta-4-ene-3,17-dione 失效分枝杆菌突变体将甾醇转化成雄甾-1,4-二烯-3,17-二酮和雄甾-4-烯-3,17-二酮
公开(公告)号：US4345029A
公开(公告)日：1982-08-17
申请号：US184698
申请日：1980-09-08
申请人： Merle G. Wovcha , Candice B. Biggs
发明人： Merle G. Wovcha , Candice B. Biggs
CPC分类号： C12R1/32 , C07J1/0011 , C12P33/005 , C12R1/33 , Y10S435/863 , Y10S435/865
摘要： Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione (AD). ADD and AD are valuable intermediates to make useful steroids.
摘要翻译： 用于新型微生物过程中的选择性降解具有2至10个碳原子的17个烷基侧链的甾体至雄甾-1,4-二烯-3,17-二酮（ADD）和雄甾-4 - 烯-3,17-二酮（AD）。 ADD和AD是有用的类固醇的有价值的中间体。
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公开(公告)号：US4293644A
公开(公告)日：1981-10-06
申请号：US849525
申请日：1977-10-09
申请人： Merle G. Wovcha , Candice B. Biggs
发明人： Merle G. Wovcha , Candice B. Biggs
CPC分类号： C07J1/0011 , C12P33/00 , Y10S435/865
摘要： Mutant which is used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to yield predominantly androst-4-ene-3,17-dione (AD) and small amounts of androsta-1,4-diene-3,17-dione (ADD). AD is a valuable intermediate to make useful steroids.
摘要翻译： 用于新型微生物过程中的选择性降解具有2至10个碳原子的17个烷基侧链的类固醇的突变体，主要产生雄甾-4-烯-3,17-二酮（AD）和少量 雄甾-1,4-二烯-3,17-二酮（ADD）。 AD是有用的类固醇的有价值的中间体。
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9.发明授权Microorganism mutant conversion of sterols to androsta-4-ene-3,17-dione 失效固醇突变体转化为雄甾-4-烯-3,17-二酮的微生物突变体
公开(公告)号：US4345030A
公开(公告)日：1982-08-17
申请号：US184722
申请日：1980-09-08
申请人： Merle G. Wovcha , Candice B. Biggs
发明人： Merle G. Wovcha , Candice B. Biggs
CPC分类号： C07J1/0011 , C12P33/00 , C12P33/005
摘要： Mutant which is used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to yield predominantly androst-4-ene-3,17-dione (AD) and small amounts of androsta-1,4-diene-3,17-dione (ADD). AD is a valuable intermediate to make useful steroids.
摘要翻译： 用于新型微生物过程中的选择性降解具有2至10个碳原子的17个烷基侧链的类固醇的突变体，主要产生雄甾-4-烯-3,17-二酮（AD）和少量 雄甾-1,4-二烯-3,17-二酮（ADD）。 AD是有用的类固醇的有价值的中间体。
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