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公开(公告)号：US4101378A
公开(公告)日：1978-07-18
申请号：US824902
申请日：1977-08-15
申请人： Daikichiro Nishikawa , Yukio Imada , Masayuki Kinoshita , Katsuhiko Takahashi , Hajime Machida , Michitaro Nagasawa
发明人： Daikichiro Nishikawa , Yukio Imada , Masayuki Kinoshita , Katsuhiko Takahashi , Hajime Machida , Michitaro Nagasawa
CPC分类号： C07J1/0022 , C07J1/0011 , C12P33/00 , Y10S435/829 , Y10S435/83 , Y10S435/831 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/866 , Y10S435/872 , Y10S435/874 , Y10S435/88 , Y10S435/886 , Y10S435/929
摘要： The improvement in a process for the production of 17-hydroxyandrosta-1,4-dien-3-one and androsta-1,4-diene-3,17-dione by the microbiological oxidation of a sterol, its 4-en-3-one derivative or its 1,4-dien-3-one derivative, which comprises adding to the culture medium at least one glyceride-containing substance selected from the group consisting of glycerides, fats, oil seeds and oil fruits in an amount sufficient that the culture medium contains at least 0.3 percent by weight of glycerides.
摘要翻译： 通过固醇微生物氧化制备17-羟基雄甾-1,4-二烯-3-酮和雄甾-1,4-二烯-3,17-二酮的方法的改进，其4-烯-3 - 酮衍生物或其1,4-二烯-3-酮衍生物，其包括向培养基中加入至少一种选自甘油酯，脂肪，油籽和油果的含甘油酯的物质，其量足以使得 培养基含有至少0.3重量％的甘油酯。
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2.发明授权Novel 3-(oxygenated alkyl)-1,9-dihydroxy and 1-hydroxy-9-keto dibenzo[b,d]p y 失效新型3-（氧化烷基）-1,9-二羟基和1-羟基-9-酮二苯并{b，d {9
公开(公告)号：US4064009A
公开(公告)日：1977-12-20
申请号：US694512
申请日：1976-06-09
IPC分类号： A61K31/35 , A61K31/352 , A61P25/04 , C07D311/80 , C12P17/06 , C07B29/02
CPC分类号： C12P17/06 , C07D311/80 , Y10S435/822 , Y10S435/834 , Y10S435/886 , Y10S435/931
摘要： 1-Hydroxy-9-keto-3-alkyl-dibenzo[b,d]pyrans or 1,9-dihydroxy-3-alkyl-dibenzo[b,d]pyrans are oxygenated on the penultimate carbon of the alkyl side chain by fermentation with a strain of the micro-organism Bacillus cereus.
摘要翻译： 通过发酵将1-羟基-9-酮-3-烷基 - 二苯并[b，d]吡喃或1,9-二羟基-3-烷基 - 二苯并[b，d]吡喃氧化在烷基侧链的倒数第二碳上 具有微生物蜡样芽孢杆菌的菌株。
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公开(公告)号：US4057469A
公开(公告)日：1977-11-08
申请号：US693685
申请日：1976-06-07
申请人： Daikichiro Nishikawa , Yukio Imada , Masayuki Kinoshita , Katsuhiko Takahashi , Hajime Machida , Michitaro Nagasawa
发明人： Daikichiro Nishikawa , Yukio Imada , Masayuki Kinoshita , Katsuhiko Takahashi , Hajime Machida , Michitaro Nagasawa
CPC分类号： C12P33/00 , C07J1/0011 , C07J1/0022 , C12P33/005 , Y10S435/822 , Y10S435/83 , Y10S435/831 , Y10S435/84 , Y10S435/88
摘要： The improvement in a process for the production of 17-hydroxyandrosta-1,4-dien-3-one and androsta-1,4-diene-3,17-dione by the microbiological oxidation of a sterol, its 4-en-3-one derivative or its 1,4-dien-3-one derivative, which comprises adding to the culture medium at least one glyceride-containing substance selected from the group consisting of glycerides, fats, oil seeds and oil fruits in an amount sufficient that the culture medium contains at least 0.3 percent by weight of glycerides.
摘要翻译： 通过固醇微生物氧化制备17-羟基雄甾-1,4-二烯-3-酮和雄甾-1,4-二烯-3,17-二酮的方法的改进，其4-烯-3 - 酮衍生物或其1,4-二烯-3-酮衍生物，其包括向培养基中加入至少一种选自甘油酯，脂肪，油籽和油果的含甘油酯的物质，其量足以使得 培养基含有至少0.3重量％的甘油酯。
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公开(公告)号：US4175006A
公开(公告)日：1979-11-20
申请号：US844366
申请日：1977-10-21
CPC分类号： C07J1/0011 , C07J1/0022 , C07J9/00 , C07J9/005 , C12P33/005 , C12P33/06 , Y10S435/865
摘要： Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.--OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.--OH BN alcohol) and 9.alpha.---hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.--OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
摘要翻译： 有价值的类固醇中间体，9α-羟基雄甾-4-烯-17β-醇-3-酮（9α-OH睾酮），9α-羟基-3-酮双十二烷-4-烯-22-醇（9α-OH BN醇）和9α-羟基-3-酮基二肉甙-4-烯-22-酸甲酯（9α-OH BN酸甲酯），其通过具有8至10个的17个烷基侧链的类固醇的微生物转化制备 碳。
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公开(公告)号：US4097335A
公开(公告)日：1978-06-27
申请号：US768025
申请日：1977-02-14
申请人： Thomas R. Pyke , Marion P. Salmond
发明人： Thomas R. Pyke , Marion P. Salmond
IPC分类号： C07D311/94 , C12P17/06 , C12R1/32 , C07B29/02
CPC分类号： C12R1/33 , C07D311/94 , C12P17/06 , Y10S435/868
摘要： Novel microbial transformation process to selectively convert steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 3a.alpha.-H-4.alpha.-�3'-propanol!-7a.beta.-methylhexahydro-1,5-indanedione hemiketal having the following structure: ##STR1## This compound can be used as an intermediate to make useful 19-nor steroids.
摘要翻译： 选择性地将具有2至10个碳原子的17-烷基侧链的甾族化合物转化为3aα-H-4α-[3'-丙醇]-7aβ-甲基六氢-1,5 - 茚满酮半缩酮具有以下结构：该化合物可用作中间体以制备有用的19-或类固醇。
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公开(公告)号：US4035236A
公开(公告)日：1977-07-12
申请号：US625653
申请日：1975-10-24
申请人： Merle G. Wovcha
发明人： Merle G. Wovcha
CPC分类号： C07J1/0022 , C07J1/0011 , C12P33/00 , Y10S435/83 , Y10S435/866 , Y10S435/868 , Y10S435/869 , Y10S435/872 , Y10S435/88 , Y10S435/886
摘要： Mutants which are used in a novel microbiological process to selectively degrade steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to 9.alpha.-hydroxyandrostenedione (9.alpha.-OH AD). 9.alpha.-OH AD is a valuable intermediate to make useful steroids.
摘要翻译： 在新型微生物过程中用于选择性降解具有2至10个碳原子的17-烷基侧链的类固醇（9α-羟基雄烯二酮（9α-OH AD））的突变体。 9α-OH AD是制备有用类固醇的有价值的中间体。
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7.发明授权
公开(公告)号：US3892630A
公开(公告)日：1975-07-01
申请号：US47320874
申请日：1974-05-24
申请人： TEIJIN LTD
发明人： KUROZUMI SEIZI , TORU TAKASHI , ISHIMOTO SACHIO
IPC分类号： C07C405/00 , C12P7/42 , C12P7/62 , C07B29/02
CPC分类号： C12R1/66 , C07C405/00 , C12P7/42 , C12P7/62 , Y10S435/913 , Y10S435/915 , Y10S435/917
摘要： A process for preparing hydroxycyclopentenone derivatives, which comprises cultivating a microorganism belonging to the genus Aspergillus in a medium containing a cyclopentenone derivative expressed by the formula (1)
WHEREIN R is a hydrogen atom or a lower alkyl group, and m is an integer of 1 to 6, TO FORM IN SAID MEDIUM A HYDROXYCYCLOPENTENONE DERIVATIVE EXPRESSED BY THE FORMULA (2)
WHEREIN R is the same as defined above, and n is equal to m or, (m - 2) when m is from 3 to 6, AND THEN RECOVERING THE HYDROXYCYCLOPENTENONE DERIVATIVE.摘要翻译： 一种制备羟基环戊烯酮衍生物的方法，其包括在含有由式（1）表示的环戊烯酮衍生物的培养基中培养属于曲霉属的微生物，其中R为氢原子或低级烷基，m为整数1 至6，表示公式中表达的羟基环戊烯酮衍生物（2）其中R与上述定义相同，当m为3至6时，n等于m或（m-2），然后 恢复羟基胆碱衍生物。
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8.发明授权
公开(公告)号：US4212940A
公开(公告)日：1980-07-15
申请号：US970885
申请日：1978-12-19
申请人： Alfred Weber , Mario Kennecke , Rudolf Muller
发明人： Alfred Weber , Mario Kennecke , Rudolf Muller
CPC分类号： C07J9/00 , C12P33/005 , Y10S435/863
摘要： In a process for preparing 21-hydroxy-20-methylpregnane derivatives by fermenting a zoosterol or a phytosterol with a culture of Mycobacterium spec. NRRL B-3683 or NRRL B-3805 or a variant or mutant thereof,an improvement comprises conducting the fermentation at a pH value of 6.0-8.0 in the presence of an amount of borate ions or an organic boron compound effective to increase the yield of the 21-hydroxy-20-methylpregnane derivatives produced.
摘要翻译： 在通过用分枝杆菌的培养物发酵甾醇或植物甾醇制备21-羟基-20-甲基孕烷衍生物的方法中， NRRL B-3683或NRRL B-3805或其变体或突变体，改进包括在一定量的硼酸根离子或有机硼化合物的存在下，在6.0-8.0的pH值下进行发酵，有效提高产率 产生的21-羟基-20-甲基孕烷衍生物。
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公开(公告)号：US4098647A
公开(公告)日：1978-07-04
申请号：US767368
申请日：1977-02-10
申请人： John C. Knight , Merle G. Wovcha
发明人： John C. Knight , Merle G. Wovcha
IPC分类号： C12N1/20 , C07D311/94 , C12P7/24 , C12P7/26 , C12P7/38 , C12P17/06 , C12R1/01 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/32 , C12R1/365 , C12R1/425 , C12R1/465 , C07B29/02
CPC分类号： C12P17/06 , C07D311/94 , C12P7/26 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/866 , Y10S435/868 , Y10S435/869 , Y10S435/872 , Y10S435/88 , Y10S435/886
摘要： Novel compounds prepared by microbial transformation using novel mutants to selectively degrade steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive. These compounds can be used as intermediates to make useful steroids.
摘要翻译： 通过使用新的突变体通过微生物转化制备的新型化合物，以选择性降解具有或不具有2至10个碳原子的17-烷基侧链的类固醇。 这些化合物可用作中间体以制备有用的类固醇。
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10.发明授权.DELTA..sup.1 Dehydrogenation of corticoids without side chain degradation by Septomyxa 失效{66 {HU 1 {B通过Septomyxa的无侧链降解的皮质激素脱氢
公开(公告)号：US4088537A
公开(公告)日：1978-05-09
申请号：US698060
申请日：1976-06-21
申请人： James P. Rolls
发明人： James P. Rolls
CPC分类号： C07J5/0076 , C07J5/0053 , C12P33/00 , Y10S435/911
摘要： This invention discloses an improved biotransformation process for the introduction of a double bond between carbon atoms 1 and 2 in corticoids by Septomyxa without degradation of the corticoid side chain.
摘要翻译： 本发明公开了一种利用Septomyxa在皮质激素中引入碳原子1和2之间的双键的改进的生物转化方法，而不降解皮质激素侧链。
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