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1.发明申请Fluorimetric Determination of Analytes By An Intramolecular Quencher-Fluorophore Conjugate 有权通过分子内猝灭剂 - 荧光团缀合物的荧光测定分析物公开(公告)号：US20080305469A1
公开(公告)日：2008-12-11
申请号：US12107116
申请日：2008-04-22
申请人： Carina Horn , Hans-Peter Josel , Jurgen Spinke , Rupert Herrmann , Dieter Heindl
发明人： Carina Horn , Hans-Peter Josel , Jurgen Spinke , Rupert Herrmann , Dieter Heindl
CPC分类号： G01N21/6428 , G01N2021/6432 , Y10S436/80 , Y10S436/904
摘要： A method and reagent for detecting the presence or amount of an analyte by a redox reaction and a fluorimetric determination, is disclosed. The reagent comprises a compound of the general formula Q-F as a redox indicator, wherein Q is a quencher group and F is a fluorophore group. The quencher group Q or/and the fluorophore group F can be reduced or oxidized, and the fluorescence can change depending on the reduction or oxidation.
摘要翻译： 公开了一种用于通过氧化还原反应和荧光测定来检测分析物的存在或量的方法和试剂。 试剂包含通式Q-F的化合物作为氧化还原指示剂，其中Q为猝灭剂基团，F为荧光团。 淬灭基团Q或/和荧光团F可以被还原或氧化，并且荧光可以根据还原或氧化而改变。
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2.发明授权Fluorimetric determination of analytes by an intramolecular quencher-fluorophore conjugate 有权通过分子内猝灭剂 - 荧光团缀合物进行荧光测定分析物公开(公告)号：US07378255B2
公开(公告)日：2008-05-27
申请号：US10766457
申请日：2004-01-28
申请人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
发明人： Carina Horn , Hans-Peter Josel , Jürgen Spinke , Rupert Herrmann , Dieter Heindl
IPC分类号： C12Q1/26
CPC分类号： G01N21/6428 , G01N2021/6432 , Y10S436/80 , Y10S436/904
摘要： A method and reagent for detecting an analyte by a redox reaction and a fluorimetric determination, is disclosed. The method comprises contacting a sample containing the analyte with a detection reagent which contains a compound of the general formula Q-F as a fluorimetric redox indicator, wherein Q is a quencher group and F is a fluorophore group.
摘要翻译： 公开了一种用于通过氧化还原反应和荧光测定来检测分析物的方法和试剂。 该方法包括将含有分析物的样品与含有通式Q-F化合物的检测试剂接触，作为荧光氧化还原指示剂，其中Q为猝灭剂基团，F为荧光团。
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公开(公告)号：US07807402B2
公开(公告)日：2010-10-05
申请号：US12107116
申请日：2008-04-22
IPC分类号： C12Q1/26
CPC分类号： G01N21/6428 , G01N2021/6432 , Y10S436/80 , Y10S436/904
摘要： A method and reagent for detecting the presence or amount of an analyte by a redox reaction and a fluorimetric determination, is disclosed. The reagent comprises a compound of the general formula Q-F as a redox indicator, wherein Q is a quencher group and F is a fluorophore group. The quencher group Q or/and the fluorophore group F can be reduced or oxidized, and the fluorescence can change depending on the reduction or oxidation.
摘要翻译： 公开了一种用于通过氧化还原反应和荧光测定来检测分析物的存在或量的方法和试剂。 试剂包含通式Q-F的化合物作为氧化还原指示剂，其中Q为猝灭剂基团，F为荧光团。 淬灭基团Q或/和荧光团F可以被还原或氧化，并且荧光可以根据还原或氧化而改变。
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4.发明授权Fast reaction kinetics of enzymes having low activity in dry chemistry layers 有权在干化学层中具有低活性的酶的快速反应动力学公开(公告)号：US09359634B2
公开(公告)日：2016-06-07
申请号：US13210564
申请日：2011-08-16
申请人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
发明人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
摘要： The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
摘要翻译： 本发明涉及一种用于确定分析物的方法以及因此合适的诊断元件。 在一种具体形式中，用于确定分析物的方法包括使含有分析物的样品与包含干试剂层的诊断元件接触。 干试剂层含有对分析物和人工辅酶特异的突变脱氢酶。 该方法还包括确定分析物存在和分析物的量中的至少一种。
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5.发明申请FAST REACTION KINETICS OF ENZYMES HAVING LOW ACTIVITY IN DRY CHEMISTRY LAYERS 有权在干燥化学物质层中具有低活性的酶的快速反应动力学公开(公告)号：US20140322737A1
公开(公告)日：2014-10-30
申请号：US13210564
申请日：2011-08-16
申请人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
发明人： Carina Horn , Claudia Gaessler-Dietsche , Dieter Heindl , Joachim Hoenes , Thomas Meier , Rainer Schmuck
摘要： The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a mutated dehydrogenase which is specific for the analyte and an artificial coenzyme. The method also includes determining at least one of analyte presence and an amount of the analyte.
摘要翻译： 本发明涉及一种用于确定分析物的方法以及因此合适的诊断元件。 在一种具体形式中，用于确定分析物的方法包括使含有分析物的样品与包含干试剂层的诊断元件接触。 干试剂层含有对分析物和人工辅酶特异的突变脱氢酶。 该方法还包括确定分析物存在和分析物的量中的至少一种。
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6.发明授权Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH 有权与稳定形式的NAD / NADH相关的化合物，方法，复合物，装置和用途公开(公告)号：US07553615B2
公开(公告)日：2009-06-30
申请号：US11460366
申请日：2006-07-27
申请人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
发明人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
IPC分类号： C12Q1/00 , C12Q1/32 , C07H19/207
CPC分类号： C07D405/14 , C07D403/12 , C07D403/14 , C07H19/04 , C07H19/167 , C12Q1/32 , C12Q1/54 , G01N2333/90209
摘要： The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.
摘要翻译： 本发明涉及稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生化检测方法和试剂基质中的应用。
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7.发明申请COMPOUNDS, METHODS, COMPLEXES, APPARATUSES AND USES RELATING TO STABILE FORMS OF NAD/NADH 有权化合物，方法，复合物，装置和与NAD / NADH的稳定形式相关的用途公开(公告)号：US20070026476A1
公开(公告)日：2007-02-01
申请号：US11460366
申请日：2006-07-27
申请人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
发明人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
CPC分类号： C07D405/14 , C07D403/12 , C07D403/14 , C07H19/04 , C07H19/167 , C12Q1/32 , C12Q1/54 , G01N2333/90209
摘要： The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.
摘要翻译： 本发明涉及稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生化检测方法和试剂基质中的应用。
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公开(公告)号：US09540702B2
公开(公告)日：2017-01-10
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/04
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译： 公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。 此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。 其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。
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公开(公告)号：US08809013B2
公开(公告)日：2014-08-19
申请号：US12020244
申请日：2008-01-25
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32
摘要： The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
摘要翻译： 本发明提供式（I）的稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生物化学检测方法和试剂盒中的用途。
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10.发明授权公开(公告)号：US09139572B2
公开(公告)日：2015-09-22
申请号：US12472105
申请日：2009-05-26
申请人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
发明人： Dieter Heindl , Joachim Hoenes , Carina Horn , Piet Herdewijn
IPC分类号： C07D405/14 , C07D403/12 , C07D403/14 , C07H19/167
CPC分类号： C07D405/14 , C07D403/12 , C07D403/14 , C07H19/04 , C07H19/167 , C12Q1/32 , C12Q1/54 , G01N2333/90209
摘要： The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.
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