公开(公告)号：US20060013832A1

公开(公告)日：2006-01-19

申请号：US11029188

申请日：2005-01-04

申请人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

发明人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

IPC分类号： A61K39/21 ,  C12N15/86

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K38/00 ,  A61K39/02 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/5158 ,  C07K14/705 ,  C07K14/70521 ,  C07K14/70532 ,  C07K16/00 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2818 ,  C07K16/2833 ,  C07K16/2866 ,  C07K16/289 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/599 ,  C12N2710/00088 ,  C12N2740/16011

摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

摘要翻译： 描述了通过激活T细胞群并用结合附属分子的配体刺激T细胞表面上的辅助分子来诱导T细胞群体增殖的方法。 T细胞增殖发生在没有外源生长因子或附属细胞的情况下。 通过刺激T细胞受体（TCR）/ CD3复合物或CD2表面蛋白来完成T细胞活化。 为了诱导活化的群体T细胞的增殖，T细胞表面上的辅助分子如CD28被与配合分子结合的配体刺激。 通过本发明的方法扩增的T细胞群体可以被遗传转导并用于免疫治疗，或可用于诊断方法。

公开(公告)号：US20060140919A1

公开(公告)日：2006-06-29

申请号：US11366331

申请日：2006-03-02

申请人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

发明人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

IPC分类号： A61K39/395 ,  A61K35/14

CPC分类号： C07K14/705 ,  A61K2039/5158 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/34 ,  C12N5/0636 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/599

摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

公开(公告)号：US20060099177A1

公开(公告)日：2006-05-11

申请号：US11326148

申请日：2006-01-05

申请人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

发明人： Carl June ,  Craig Thompson ,  Gary Nabel ,  Gary Gray ,  Paul Rennert

IPC分类号： A61K35/14 ,  C12N5/08

CPC分类号： C07K16/2809 ,  A61K35/17 ,  A61K2039/507 ,  C07K16/2806 ,  C07K16/2818 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2319/30 ,  C12N2740/16011

摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

公开(公告)号：US20060205069A1

公开(公告)日：2006-09-14

申请号：US11364102

申请日：2006-02-28

申请人： Carl June ,  Craig Thompson ,  Gary Gray ,  Paul Rennert

发明人： Carl June ,  Craig Thompson ,  Gary Gray ,  Paul Rennert

IPC分类号： G01N33/551 ,  C12N5/06

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5158 ,  C07K14/705 ,  C07K14/70521 ,  C07K14/70532 ,  C07K16/00 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2818 ,  C07K16/2833 ,  C07K16/2866 ,  C07K16/289 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/599 ,  C12N2740/16011 ,  C12N2795/00011

摘要： Compositions for inducing a population of T cells to proliferate in vitro by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population of T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the composition of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis

摘要翻译： 描述了通过激活T细胞群并用结合辅助分子的配体刺激T细胞表面上的辅助分子来诱导T细胞群体在体外增殖的组合物。 T细胞增殖发生在没有外源生长因子或附属细胞的情况下。 通过刺激T细胞受体（TCR）/ CD3复合物或CD2表面蛋白来完成T细胞活化。 为了诱导活化的T细胞群体的增殖，T细胞表面上的辅助分子例如CD28用与配体分子结合的配体刺激。 通过本发明的组合物扩增的T细胞群体可以被遗传转导并用于免疫治疗或可用于诊断方法

公开(公告)号：US20060246587A1

公开(公告)日：2006-11-02

申请号：US11476288

申请日：2006-06-28

申请人： Carl June ,  Craig Thompson ,  Suil Kim

发明人： Carl June ,  Craig Thompson ,  Suil Kim

IPC分类号： C12N15/867 ,  C12N5/08

CPC分类号： C07K16/2818 ,  A61K48/00 ,  C07K16/2809 ,  C12N15/87

摘要： A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.

摘要翻译： 描述了用包含基因的核酸分子转染T细胞的方法，使得该基因在T细胞中表达。 T细胞在引入核酸分子之前被刺激并增殖。

公开(公告)号：US20060199780A1

公开(公告)日：2006-09-07

申请号：US11296725

申请日：2005-12-02

申请人： Carl June ,  Craig Thompson

发明人： Carl June ,  Craig Thompson

IPC分类号： A61K48/00 ,  A61K39/395

CPC分类号： C07K16/18 ,  C07K2317/73

摘要： Methods for protecting a T cell from cell death are described. The methods involve contacting the T cell with an agent which augments the bcl-XL protein level in the T cell such that it is protected from cell death. The invention further pertains to methods for increasing the susceptibility of a T cell to cell death, comprising contacting the T cell with at least one agent which decreases bcl-XL protein level in the T cell. Both in vivo and in vitro methods are described.

摘要翻译： 描述了保护T细胞免于细胞死亡的方法。 所述方法包括使T细胞与增加T细胞中的bcl-X L L蛋白水平的试剂接触，使得其被保护免于细胞死亡。 本发明还涉及增加T细胞对细胞死亡的易感性的方法，包括使T细胞与降低T细胞中bcl-XL蛋白水平的至少一种试剂接触。 描述体内和体外方法。

公开(公告)号：US08973878B2

公开(公告)日：2015-03-10

申请号：US12056384

申请日：2008-03-27

申请人： Craig Thompson

发明人： Craig Thompson

IPC分类号： A47B96/00 ,  F16M13/02 ,  A47G1/17 ,  A47K10/10

CPC分类号： F16M13/02 ,  A47G1/175 ,  A47K10/10 ,  A47K2201/02 ,  Y10T29/49826 ,  Y10T403/7005

摘要： Herein are disclosed systems and methods and assemblies for mounting an accessory base to a surface (e.g., a wall surface). The systems comprise a mounting bracket which can be attached to the surface by a double-faced adhesive such as a stretch-releasing adhesive. The accessory base can be attached to the mounting bracket.

摘要翻译： 本文公开了用于将附件基座安装到表面（例如，壁表面）的系统和方法和组件。 这些系统包括安装支架，该安装支架可以通过诸如拉伸释放粘合剂的双面粘合剂附接到表面。 附件底座可以安装到安装支架上。

公开(公告)号：US08596473B2

公开(公告)日：2013-12-03

申请号：US11849402

申请日：2007-09-04

申请人： Peter J. Newbould ,  Ivana Babic ,  Craig Thompson ,  James L. Bries ,  Russell G. Pihlstrom

发明人： Peter J. Newbould ,  Ivana Babic ,  Craig Thompson ,  James L. Bries ,  Russell G. Pihlstrom

IPC分类号： A47F5/08

CPC分类号： A47G1/175 ,  A47B96/067 ,  A47K1/09

摘要： A horizontally mounted shelf assembly includes an elongated support rail, at least one accessory slidaby connected with the support rail, and at least one stretch releasing adhesive strip arranged between the support rail and a wall for securing the shelf assembly to the wall. Each accessory may also be separately mounted on the wall using stretch releasing adhesive strips.

摘要翻译： 水平安装的搁板组件包括细长的支撑轨道，至少一个与支撑轨道连接的附件滑动件，以及布置在支撑轨道和壁之间的至少一个拉伸释放粘合剂条，用于将搁板组件固定到壁上。 每个附件也可以使用拉伸释放胶带单独地安装在墙壁上。

公开(公告)号：US20130288284A1

公开(公告)日：2013-10-31

申请号：US13617332

申请日：2012-09-14

申请人： Leonard Luan C Dang ,  Stefan Gross ,  Hyun Gyung Jang ,  Shengfang Jin ,  Shin-San Michael Su ,  Craig Thompson

发明人： Leonard Luan C Dang ,  Stefan Gross ,  Hyun Gyung Jang ,  Shengfang Jin ,  Shin-San Michael Su ,  Craig Thompson

IPC分类号： C12Q1/32

CPC分类号： C12Q1/6886 ,  A61K31/015 ,  A61K31/05 ,  A61K31/122 ,  A61K31/194 ,  A61K31/225 ,  A61K31/355 ,  A61K31/375 ,  A61K31/381 ,  A61K31/522 ,  A61K31/7004 ,  A61K31/713 ,  A61K38/063 ,  A61K38/44 ,  C12Q1/32 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156

摘要： Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).

公开(公告)号：US20120185436A1

公开(公告)日：2012-07-19

申请号：US13006212

申请日：2011-01-13

申请人： Tony J. Lee ,  Craig Thompson

发明人： Tony J. Lee ,  Craig Thompson

IPC分类号： G06F17/30

CPC分类号： G06F17/00 ,  G01R19/2513 ,  G06F3/00 ,  G06F13/00 ,  Y02T10/82

摘要： Disclosed herein are a variety of systems and methods that may be utilized to facilitate the configuration of intelligent electronic devices using design templates. A design template may be configured to make available to the user only particular inputs that might need to be modified for a specific application of the intelligent electronic device. Use of templates, as disclosed herein, may simplify the task of configuring an intelligent electronic device. Data entered by the user may be utilized to generate a plurality of intelligent electronic device settings. According to various embodiments, the data entered by a user may be stored on the intelligent electronic device in an archive file. The archive file may also include other design information that a user may desire to store on the intelligent electronic device.

摘要翻译： 本文公开了可以利用设计模板来促进智能电子设备的配置的各种系统和方法。 设计模板可以被配置为仅向用户提供对于智能电子设备的特定应用可能需要修改的特定输入。 使用如本文所公开的模板可以简化配置智能电子设备的任务。 可以利用用户输入的数据来生成多个智能电子设备设置。 根据各种实施例，用户输入的数据可以存储在归档文件中的智能电子设备上。 归档文件还可以包括用户可能想要存储在智能电子设备上的其他设计信息。