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公开(公告)号：US5272263A
公开(公告)日：1993-12-21
申请号：US452675
申请日：1989-12-18
申请人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
发明人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
IPC分类号： G01N33/50 , A61K31/7105 , A61K35/16 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/00 , A61P1/00 , A61P17/00 , A61P29/00 , A61P35/00 , C07H21/04 , C07K7/00 , C07K14/00 , C07K14/195 , C07K14/41 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/42 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/04 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/62 , C12N15/63 , C12N15/70 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/00 , G01N33/15 , G01N33/53 , G01N33/536 , G01N33/543 , G01N33/566 , G01N33/577 , C07K13/00 , C12P21/06
CPC分类号： C07K16/28 , A61K47/48561 , C07K14/70564 , C07K16/2836 , C07K16/2854 , C07K16/4241 , C07K16/4258 , C12N15/1138 , A61K38/00 , C07K2317/76 , C07K2319/30 , C12N2310/11 , C12N2310/12
摘要： DNA sequences encoding vascular cell adhesion molecules 1 and 1b ("VCAM1" and "VCAM1B"), recombinant DNA molecules comprising those sequences, and unicellular hosts transformed with those recombinant DNA molecules.
摘要翻译： 编码血管细胞粘附分子1和1b（“VCAM1”和“VCAM1B”）的DNA序列，包含那些序列的重组DNA分子和用这些重组DNA分子转化的单细胞宿主。
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公开(公告)号：US06252043B1
公开(公告)日：2001-06-26
申请号：US08310890
申请日：1994-09-22
申请人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
发明人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
IPC分类号： C07K14705
CPC分类号： C07K16/28 , A61K38/00 , A61K47/6849 , C07K14/70564 , C07K16/2836 , C07K16/2854 , C07K16/4241 , C07K16/4258 , C07K2317/76 , C07K2319/30 , C12N15/1138 , C12N2310/11 , C12N2310/12
摘要： VCAM1 polypeptides and VCAM11/ICAM fusion proteins are disclosed.
摘要翻译： 公开了VCAM1多肽和VCAM11 / ICAM融合蛋白
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公开(公告)号：US06307025B1
公开(公告)日：2001-10-23
申请号：US08482073
申请日：1995-06-07
申请人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
发明人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
IPC分类号： C07K1646
CPC分类号： C12N15/1138 , A61K38/00 , A61K47/6849 , C07K14/70564 , C07K16/2854 , Y02A50/473
摘要： VCAM fusion proteins capable of binding to VLA4, and DNA molecules coding on these fusions.
摘要翻译： 能够结合VLA4的VCAM融合蛋白，以及编码这些融合物的DNA分子
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4.发明授权Endothelial cell-leukocyte adhesion molecules (ELAMs) and molecules involved in leukocyte adhesion (MILAs) 失效内皮细胞 - 白细胞粘附分子（ELAM）和参与白细胞粘附的分子（MILAs）
公开(公告)号：US5367056A
公开(公告)日：1994-11-22
申请号：US35674
申请日：1993-03-23
申请人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
发明人： Catherine A. Hession , Roy R. Lobb , Susan E. Goelz , Laurelee Osborn , Christopher D. Benjamin , Margaret D. Rosa
IPC分类号： G01N33/50 , A61K31/7105 , A61K35/16 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/00 , A61P1/00 , A61P17/00 , A61P29/00 , A61P35/00 , C07H21/04 , C07K7/00 , C07K14/00 , C07K14/195 , C07K14/41 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/42 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/04 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/62 , C12N15/63 , C12N15/70 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/00 , G01N33/15 , G01N33/53 , G01N33/536 , G01N33/543 , G01N33/566 , G01N33/577 , C07K13/00
CPC分类号： C07K16/28 , A61K47/48561 , C07K14/70564 , C07K16/2836 , C07K16/2854 , C07K16/4241 , C07K16/4258 , C12N15/1138 , A61K38/00 , C07K2317/76 , C07K2319/30 , C12N2310/11 , C12N2310/12
摘要： DNA sequences encoding endothelial cell-leukocyte adhesion molecules ELAMs, methods for producing such molecules, and ELAMs (including the specific molecules ELAM1 and VLAM1 and 1b) essentially free of normally associated animal proteins are disclosed.DNA sequences encoding molecules involved in leukocyte adhesion (MILAs), methods for producing such molecules and MILAs (including the specific molecule, CDX) essentially free of normally associated animal proteins are also disclosed. Antibody preparations which are reactive for MILAs and also disclosed.Methods for identifying molecules which inhibit binding of leukocytes to endothelial cells, methods for inhibiting leukocyte binding to endothelial cells, and methods for detecting acute inflammation are disclosed.
摘要翻译： 公开了编码内皮细胞 - 白细胞粘附分子的DNA序列，ELAMs，生产这些分子的方法，以及基本上不含通常关联的动物蛋白质的ELAM（包括特异性分子ELAM1和VLAM1和1b）。 还公开了编码参与白细胞粘附（MILAs）的分子的DNA序列，用于产生此类分子的方法和基本上不含通常关联的动物蛋白质的MILAs（包括特定分子CDX）。 对MILA具有反应性的抗体制剂也被公开。 公开了用于鉴定抑制白细胞与内皮细胞结合的分子的方法，用于抑制白细胞与内皮细胞结合的方法，以及用于检测急性炎症的方法。
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公开(公告)号：US4753879A
公开(公告)日：1988-06-28
申请号：US644537
申请日：1984-08-27
申请人： Joseph J. Rosa , Margaret D. Rosa
发明人： Joseph J. Rosa , Margaret D. Rosa
CPC分类号： C12N9/6459 , C12Y304/21069 , A61K38/00
摘要： Modified human tissue plasminogen activators, the DNA sequences coding on expression for them and methods of making them in hosts transformed with those DNA sequences. The single chain form of these modified human t-PAs, t-PA (Lys 277.fwdarw.X), has a longer half life than the single chain form of native, or recombinant, t-PA, yet, in the two chain form these modified t-PAs have substantially the same affinity for fibrin and substantially the same activity as the two chain form of native, or recombinant, t-PA.
摘要翻译： 修饰的人组织纤溶酶原激活剂，编码它们的表达的DNA序列和在用这些DNA序列转化的宿主中制备它们的方法。 这些修饰的人t-PA（t-PA（Lys 277-> X））的单链形式比单链形式的天然或重组t-PA具有更长的半衰期，但是在两链形式 这些修饰的t-PA对纤维蛋白具有基本上相同的亲和力，并且与两种链形式的天然或重组t-PA具有基本上相同的活性。
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6.发明授权Methods of inhibiting T-cell dependent proliferation of peripheral blood lymphocytes using the CD2-binding domain of lymphocyte function associated antigen 3 失效使用淋巴细胞功能相关抗原的CD2结合结构域抑制外周血淋巴细胞T细胞依赖性增殖的方法3
公开(公告)号：US5728677A
公开(公告)日：1998-03-17
申请号：US459512
申请日：1995-06-02
IPC分类号： A61K38/00 , A61K39/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/06 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , A61K38/17
CPC分类号： C07K14/70528 , C07K16/00 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/75 , Y10S424/809 , Y10S435/81 , Y10S530/868
摘要： Polypeptides and proteins comprising the CD2-binding domain of LFA-3 are disclosed. DNA sequences that code on expression for those polypeptides and proteins, methods of producing and using those polypeptides and proteins, and therapeutic and diagnostic compositions are also disclosed. Deletion mutants unable to bind CD2 and methods for their use are also disclosed. In addition, fusion proteins which comprise the CD2-binding domain of LFA-3 and a portion of a protein other than LFA-3, DNA sequences encoding those fusion proteins, methods for producing those fusion proteins, and uses of those fusion proteins are disclosed.
摘要翻译： 公开了包含LFA-3的CD2结合结构域的多肽和蛋白质。 还公开了编码那些多肽和蛋白质的表达的DNA序列，产生和使用那些多肽和蛋白质的方法，以及治疗和诊断组合物。 还公开了不能结合CD2的缺失突变体及其使用方法。 此外，公开了包含LFA-3的CD2结合结构域和一部分不同于LFA-3的蛋白质的融合蛋白，编码这些融合蛋白的DNA序列，产生这些融合蛋白的方法以及这些融合蛋白的用途的融合蛋白 。
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7.发明授权Anti-CD4 antibody homologs useful in prophylaxis and treatment of AIDS, ARC and HIV infection 失效抗CD4抗体同系物可用于预防和治疗AIDS，ARC和HIV感染
公开(公告)号：US5871732A
公开(公告)日：1999-02-16
申请号：US916098
申请日：1991-11-27
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P31/00 , A61P31/12 , A61P31/18 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N5/10 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/569 , C08G75/14
CPC分类号： C07K16/2812 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： Anti-CD4 antibody homologs, DNA sequences and recombinant DNA molecules encoding them, prophylactic, immunotherapeutic and diagnostic compositions comprising those antibody homologs, and methods for preventing or treating diseases in mammals, including humans, caused by infective agents whose primary targets are CD4.sup.+ lymphocytes. Such diseases include acquired immune deficiency syndrome ("AIDS"), AIDS related complex, and human immunodeficiency virus infection.
摘要翻译： 包含抗体同系物的抗CD4抗体同系物，DNA序列和编码它们的重组DNA分子，预防性，免疫治疗和诊断组合物，以及预防或治疗哺乳动物（包括人）由主要靶标为CD4 +淋巴细胞的感染因子引起的疾病的方法。 这些疾病包括获得性免疫缺陷综合征（“AIDS”），AIDS相关复合物和人类免疫缺陷病毒感染。
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公开(公告)号：US5863528A
公开(公告)日：1999-01-26
申请号：US451213
申请日：1995-05-26
IPC分类号： C12N15/09 , A61K35/28 , A61K38/00 , A61K38/19 , A61K39/00 , A61P37/06 , C07H21/04 , C07K14/475 , C07K14/52 , C07K14/535 , C07K14/54 , C12N5/10 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： A61K35/28 , A61K39/001 , C07K14/475 , C07K14/52 , C07K14/535 , C07K14/54 , A61K38/00 , A61K39/00 , C07K2319/00 , Y10S514/885
摘要： A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.
摘要翻译： 一种通过向接受者施用猪骨髓细胞来增强异种受体中的猪移植的耐受性的方法，以及通过将所述细胞暴露于至少一种基本上纯的猪细胞因子和猪细胞因子来增强猪骨髓细胞的增殖和移植， 基本上不含其他猪蛋白质，并且优先增强猪骨髓细胞在其他物种的骨髓细胞存在下的增殖和移植。 这种猪细胞因子的蛋白质和DNA序列。
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9.发明授权Method of using CD2-binding domain of lymphocyte function associated antigen 3 to initiate T cell activation 失效使用淋巴细胞功能相关抗原3的CD2结合结构域启动T细胞活化的方法
公开(公告)号：US5928643A
公开(公告)日：1999-07-27
申请号：US460132
申请日：1995-06-02
IPC分类号： A61K38/00 , A61K38/17 , A61P37/04 , C07K14/705 , C12N15/12 , C12N15/62 , C12N15/70 , C12Q1/68 , A61K39/395 , A61K38/16
CPC分类号： C07K14/70528 , A61K38/1774 , C07K2319/00 , C07K2319/02 , C07K2319/30
摘要： Polypeptides and proteins comprising the CD2-binding domain of LFA-3 are disclosed. DNA sequences that code on expression for those polypeptides and proteins, methods of producing and using those polypeptides and proteins, and therapeutic and diagnostic compositions are also disclosed. Deletion mutants unable to bind CD2 and methods for their use are also disclosed. In addition, fusion proteins which comprise the CD2-binding domain of LFA-3 and a portion of a protein other than LFA-3, DNA sequences encoding those fusion proteins, methods for producing those fusion proteins, and uses of those fusion proteins are disclosed.
摘要翻译： 公开了包含LFA-3的CD2结合结构域的多肽和蛋白质。 还公开了编码那些多肽和蛋白质的表达的DNA序列，产生和使用那些多肽和蛋白质的方法，以及治疗和诊断组合物。 还公开了不能结合CD2的缺失突变体及其使用方法。 此外，公开了包含LFA-3的CD2结合结构域和一部分不同于LFA-3的蛋白质的融合蛋白，编码这些融合蛋白的DNA序列，这些融合蛋白的制备方法和这些融合蛋白的用途 。
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公开(公告)号：US5914111A
公开(公告)日：1999-06-22
申请号：US459657
申请日：1995-06-02
IPC分类号： A61K38/00 , A61K39/00 , A61P17/02 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/06 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , A61K39/395 , A61K38/16 , C12N15/62
CPC分类号： C07K14/70528 , C07K16/00 , A61K38/00 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/75 , Y10S424/809 , Y10S435/81 , Y10S530/868
摘要： Polypeptides and proteins comprising the CD2-binding domain of LFA-3 are disclosed. DNA sequences that code on expression for those polypeptides and proteins, methods of producing and using those polypeptides and proteins, and therapeutic and diagnostic compositions are also disclosed. Deletion mutants unable to bind CD2 and methods for their use are also disclosed. In addition, fusion proteins which comprise the CD2-binding domain of LFA-3 and a portion of a protein other than LFA-3, DNA sequences encoding those fusion proteins, methods for producing those fusion proteins, and uses of those fusion proteins are disclosed.
摘要翻译： 公开了包含LFA-3的CD2结合结构域的多肽和蛋白质。 还公开了编码那些多肽和蛋白质的表达的DNA序列，产生和使用那些多肽和蛋白质的方法，以及治疗和诊断组合物。 还公开了不能结合CD2的缺失突变体及其使用方法。 此外，公开了包含LFA-3的CD2结合结构域和一部分不同于LFA-3的蛋白质的融合蛋白，编码这些融合蛋白的DNA序列，产生这些融合蛋白的方法以及这些融合蛋白的用途的融合蛋白 。
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