公开(公告)号：US20250066709A1

公开(公告)日：2025-02-27

申请号：US18810386

申请日：2024-08-20

Applicant: Cellares Corporation

Inventor： Wayne E. GROUT ,  Wilson Wai TOY

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/34 ,  C12M1/36 ,  C12M3/00

Abstract: The present disclosure relates to systems, devices, and methods for automated cell processing within a cell processing system. In an embodiment, the present disclosure relates to a cartridge comprising a bioreactor module comprising a bioreactor, a first thermal compartment positioned adjacent the bioreactor, and a second thermal compartment positioned adjacent the bioreactor, and a fluidic manifold coupling the first and second thermal compartments to the bioreactor.

公开(公告)号：US20240402206A1

公开(公告)日：2024-12-05

申请号：US18731095

申请日：2024-05-31

Applicant: Cellares Corporation

Inventor： Andrew BOPPART ,  Jebsen MAN ,  Andrew Philip Gust PETERSON ,  Wilson Wai TOY ,  Peter TURNER

IPC: G01N35/10 ,  G01N35/00 ,  G01N35/04

Abstract: The present disclosure relates to systems, devices, and methods for automated reagent storage within a cell processing system. In an embodiment, the present disclosure relates to a reagent vault system comprising a refrigeration unit for storing cell processing reagents, a rotating carousel configured to receive one or more fluid devices, the fluid devices configured to store the cell processing reagents, and at least one sensor for measuring at least one parameter of the reagent vault system.

公开(公告)号：US20240165613A1

公开(公告)日：2024-05-23

申请号：US18487884

申请日：2023-10-16

Applicant: Cellares Corporation

Inventor： Vladimir AZERSKY ,  Fabian GERLINGHAUS ,  Daniele MALLEO ,  Brian Alexander PESCH ,  Bharat S. THAKKAR ,  Wilson Wai TOY

IPC: B01L3/00 ,  A61L2/04 ,  A61L2/20 ,  B01J19/00 ,  C12M1/00 ,  C12M1/36 ,  C12M3/00 ,  C12N5/00 ,  A61L2/08

CPC classification number: B01L3/502715 ,  A61L2/04 ,  A61L2/20 ,  A61L2/206 ,  A61L2/208 ,  B01J19/004 ,  B01L13/00 ,  C12M23/44 ,  C12M23/50 ,  C12M41/48 ,  C12N5/00 ,  C12N5/0081 ,  A61L2/08 ,  A61L2202/11 ,  A61L2202/122 ,  A61L2202/123 ,  A61L2202/14 ,  B01J2219/0002 ,  B01J2219/0074 ,  B01L2200/027 ,  B01L2300/049

Abstract: Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

公开(公告)号：US20230321650A1

公开(公告)日：2023-10-12

申请号：US18141329

申请日：2023-04-28

Applicant: Cellares Corporation

Inventor： Vladimir AZERSKY ,  Fabian GERLINGHAUS ,  Daniele MALLEO ,  Brian Alexander PESCH ,  Bharat S. THAKKAR ,  Wilson Wai TOY

IPC: B01L3/00 ,  B01J19/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/36 ,  A61L2/04 ,  A61L2/20 ,  C12N5/00

CPC classification number: B01L3/502715 ,  A61L2/04 ,  A61L2/20 ,  A61L2/206 ,  A61L2/208 ,  B01J19/004 ,  B01L13/00 ,  C12M23/44 ,  C12M23/50 ,  C12M41/48 ,  C12N5/00 ,  C12N5/0081 ,  A61L2/08 ,  A61L2202/11 ,  A61L2202/122 ,  A61L2202/14 ,  B01J2219/0002 ,  B01J2219/0074 ,  B01L2200/027 ,  B01L2300/049

Abstract: Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

公开(公告)号：US20250065331A1

公开(公告)日：2025-02-27

申请号：US18811490

申请日：2024-08-21

Applicant: Cellares Corporation

Inventor： Daniele MALLEO ,  Wilson Wai TOY

IPC: B01L3/00 ,  G01N35/00

Abstract: The present disclosure relates to systems, devices, and methods for automated cell sorting within a cell processing system. In an embodiment, the present disclosure relates to an automated cell sorting system comprising a cartridge having a cell sorting module, where the cell sorting module comprises a flow cell, and an instrument within a bay of a cell processing workcell, where the instrument comprises a magnetic array couplable to the flow cell, each of the magnets within the magnetic array having a width of w and being spaced apart by between about w/3 to about 3/4w, and wherein the flow cell has a height of between about 1/12w to about 1/8w.

公开(公告)号：US20240390898A1

公开(公告)日：2024-11-28

申请号：US18792360

申请日：2024-08-01

Applicant: Cellares Corporation

Inventor： Vladimir AZERSKY ,  Fabian GERLINGHAUS ,  Daniele MALLEO ,  Brian Alexander PESCH ,  Bharat S. THAKKAR ,  Wilson Wai TOY

IPC: B01L3/00 ,  A61L2/04 ,  A61L2/08 ,  A61L2/20 ,  B01J19/00 ,  C12M1/00 ,  C12M1/36 ,  C12M3/00 ,  C12N5/00

Abstract: Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

公开(公告)号：US20250129321A1

公开(公告)日：2025-04-24

申请号：US18920607

申请日：2024-10-18

Applicant: Cellares Corporation

Inventor： Daniele MALLEO ,  Bharat THAKKAR ,  Wilson Wai TOY ,  Matthias WEBER ,  Yiming XU ,  Joon Mo YANG

IPC: C12M1/00 ,  C12M1/34 ,  C12M3/04

Abstract: The present disclosure relates to systems, devices, and methods for controlling fluid flow within a cell processing system. In an embodiment, the present disclosure relates to a device having a rotor comprising one or more rollers configured to compress a first fluid conduit, a first lever arm defining a proximal portion and a distal portion, where the first lever arm comprises a first hinge at the proximal portion, and a second hinge in between the proximal portion and the distal portion, a spring coupled to the distal portion, and a second lever arm, where the first and second lever arms are aligned with the rotor and are configured to receive the first fluid conduit.

公开(公告)号：US20250066708A1

公开(公告)日：2025-02-27

申请号：US18810388

申请日：2024-08-20

Applicant: Cellares Corporation

Inventor： Lily Elizabeth BURKEEN ,  Kelly F. CURRAN ,  Wilson Wai TOY ,  Matthias WEBER

IPC: C12M1/34 ,  C12M1/00 ,  C12M3/00

Abstract: The present disclosure relates to systems, devices, and methods for automated fluid control within a cell processing system. In an embodiment, the present disclosure relates to a cartridge having a fluidic manifold comprising a first end panel, a second end panel, and a central panel connecting the first and second end panels, where each of the first and second end panels comprises a plurality of fluidic pathways model therein and a plurality of valves for controlling fluid flow through the plurality of fluidic pathways.

公开(公告)号：US20240390897A1

公开(公告)日：2024-11-28

申请号：US18792358

申请日：2024-08-01

Applicant: Cellares Corporation

Inventor： Vladimir AZERSKY ,  Fabian GERLINGHAUS ,  Daniele MALLEO ,  Brian Alexander PESCH ,  Bharat S. THAKKAR ,  Wilson Wai TOY

IPC: B01L3/00 ,  A61L2/04 ,  A61L2/08 ,  A61L2/20 ,  B01J19/00 ,  C12M1/00 ,  C12M1/36 ,  C12M3/00 ,  C12N5/00

Abstract: Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

公开(公告)号：US20240369586A1

公开(公告)日：2024-11-07

申请号：US18652602

申请日：2024-05-01

Applicant: Cellares Corporation

Inventor： Isabel TIAN ,  Wilson Wai TOY

IPC: G01N35/04 ,  G01N35/00

Abstract: The present disclosure relates to systems, devices, and methods for spinoculation and counterflow centrifugal elutriation. In an embodiment, the present disclosure relates to a cartridge in an automated system, comprising a liquid transfer bus, a module fluidically coupled to the liquid transfer bus, the module comprising two sub-modules, each configured to perform separate cell processing steps, and at least one selector valve configured to direct fluid to at least one of the sub-modules.