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    APPARATUS AND METHOD FOR MONITORING EARLY FORMATION OF STEAM POP DURING ABLATION
    1.
    发明申请
    APPARATUS AND METHOD FOR MONITORING EARLY FORMATION OF STEAM POP DURING ABLATION 有权
    装置和方法，用于监测早期形成的蒸汽釜在排水期间

    公开(公告)号：US20080097220A1

    公开(公告)日：2008-04-24

    申请号：US11552075

    申请日：2006-10-23

    申请人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    发明人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    IPC分类号： A61B6/00

    CPC分类号： A61B18/1492 ,  A61B5/0084 ,  A61B18/1233 ,  A61B2017/00061 ,  A61B2017/00066 ,  A61B2017/00123 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666

    摘要： A system and method that enable real-time optical measurements of tissue reflection spectral characteristics while performing ablation, involves the radiation of tissue and recapturing of light from the tissue to monitor changes in the reflected optical intensity as an indicator of steam formation in the tissue for prevention of steam pop. The system includes a catheter adapted to collect light reflected from tissue undergoing ablation, a detection component that identifies and separates constituent wavelengths of collected light, a quantification apparatus for generating measured light intensity data for the collected light, and a processor that analyses the measured light intensity data in relation to time. The system may include a graphical display and/or an audio output (e.g., speaker) that provide visual and/or audio alarm when the system infers formation of a steam pocket in the tissue. The method for monitoring formation of steam pocket during ablation, wherein a measured reflectance spectral intensity MRSI versus time is analyzed, includes delivering light to tissue, delivering energy for ablation at tissue and measuring the reflectance spectral intensity of the tissue, wherein observation is made as to whether the MRSI initially increases in a specified time period followed by a decrease at a specified rate in the MRSI. If there is no decrease in the MRSI, then delivery of ablation energy to tissue continues. However, if there is a decrease in the MRSI within a specified time and at a specified rate, then the method infers the formation of a steam pocket and decreases or discontinues the delivery of ablative energy to tissue.

    摘要翻译： 能够在进行消融时实现组织反射光谱特征的实时光学测量的系统和方法涉及组织的辐射和来自组织的光的重新捕获，以监测反射光强度的变化，作为组织中蒸汽形成的指标 预防蒸汽流行。 所述系统包括适于收集经历消融的组织反射的光的导管，识别并分离所收集的光的组成波长的检测部件，用于产生所收集的光的测量光强度数据的量化装置，以及分析所测量的光的处理器 强度数据与时间有关。 该系统可以包括图形显示和/或音频输出（例如，扬声器），当系统推断组织中的蒸汽口袋的形成时，提供视觉和/或音频报警。 在消融期间监测蒸汽袋形成的方法，其中分析测量的反射光谱强度MRSI与时间的关系，包括将光传送到组织，在组织处输送消融能量并测量组织的反射光谱强度，其中观察为 MRSI是否在特定时间段内最初增加，之后MRSI中以指定的速率下降。 如果MRSI没有减少，那么消融能量传递给组织就会持续下去。 然而，如果MRSI在规定时间内以规定的速率下降，则该方法推测形成蒸汽口袋并减少或停止向组织输送烧蚀能量。

    APPARATUS AND METHOD FOR MONITORING EARLY FORMATION OF STEAM POP DURING ABLATION
    2.
    发明申请
    APPARATUS AND METHOD FOR MONITORING EARLY FORMATION OF STEAM POP DURING ABLATION 有权
    装置和方法，用于监测早期形成的蒸汽釜在排水期间

    公开(公告)号：US20120245572A1

    公开(公告)日：2012-09-27

    申请号：US13434554

    申请日：2012-03-29

    申请人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    发明人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1492 ,  A61B5/0084 ,  A61B18/1233 ,  A61B2017/00061 ,  A61B2017/00066 ,  A61B2017/00123 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666

    摘要： A system for measuring real-time tissue reflection spectral characteristics during ablation includes a catheter for collecting light reflected from tissue undergoing ablation, a detection component for separating constituent wavelengths of the collected light, a quantification apparatus for generating measured light intensity data of the collected light, and a processor for analyzing the data in relation to time. A method for monitoring formation of steam pop during ablation includes delivering light to tissue, delivering ablative energy to the tissue, measuring the reflectance spectral intensity of the tissue, and observing whether the measured reflectance spectral instensity (MRSI) initially increases in a specified time period followed by a decrease at a specified rate. If the MRSI does not decrease, delivery of ablation energy continues. If the MRSI decreases within the specified time at the specified rate, formation of a steam pocket is inferred and delivery of ablative energy is decreased or discontinued.

    摘要翻译： 用于测量消融期间的实时组织反射光谱特性的系统包括用于收集从经历消融的组织反射的光的导管，用于分离所收集的光的组成波长的检测部件，用于产生所收集的光的测量的光强度数据的量化装置 以及用于分析与时间有关的数据的处理器。 用于监测消融期间蒸汽流出形成的方法包括将光传送到组织，向组织输送消融能量，测量组织的反射光谱强度，以及观察测量的反射光谱强度（MRSI）在指定时间段内是否最初增加 其次是以指定的速度下降。 如果MRSI不减少，消融能量的传递将继续下去。 如果MRSI在指定时间内以指定的速率下降，则推断形成蒸汽口袋，并且释放能量的传送减少或停止。

    Apparatus and method for monitoring early formation of steam pop during ablation
    3.
    发明授权
    Apparatus and method for monitoring early formation of steam pop during ablation 有权
    用于监测消融期间早期形成蒸汽流的装置和方法

    公开(公告)号：US08147484B2

    公开(公告)日：2012-04-03

    申请号：US11552075

    申请日：2006-10-23

    申请人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    发明人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    IPC分类号： A61B18/04

    CPC分类号： A61B18/1492 ,  A61B5/0084 ,  A61B18/1233 ,  A61B2017/00061 ,  A61B2017/00066 ,  A61B2017/00123 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666

    摘要： A system and method that enable real-time optical measurements of tissue reflection spectral characteristics while performing ablation, involves the radiation of tissue and recapturing of light from the tissue to monitor changes in the reflected optical intensity as an indicator of steam formation in the tissue for prevention of steam pop. The system includes a catheter adapted to collect light reflected from tissue undergoing ablation, a detection component that identifies and separates constituent wavelengths of collected light, a quantification apparatus for generating measured light intensity data for the collected light, and a processor that analyses the measured light intensity data in relation to time. The system may include a graphical display and/or an audio output (e.g., speaker) that provide visual and/or audio alarm when the system infers formation of a steam pocket in the tissue. The method for monitoring formation of steam pocket during ablation, wherein a measured reflectance spectral intensity MRSI versus time is analyzed, includes delivering light to tissue, delivering energy for ablation at tissue and measuring the reflectance spectral intensity of the tissue, wherein observation is made as to whether the MRSI initially increases in a specified time period followed by a decrease at a specified rate in the MRSI. If there is no decrease in the MRSI, then delivery of ablation energy to tissue continues. However, if there is a decrease in the MRSI within a specified time and at a specified rate, then the method infers the formation of a steam pocket and decreases or discontinues the delivery of ablative energy to tissue.

    摘要翻译： 能够在进行消融时实现组织反射光谱特征的实时光学测量的系统和方法涉及组织的辐射和来自组织的光的重新捕获，以监测反射光强度的变化，作为组织中蒸汽形成的指标 预防蒸汽流行。 所述系统包括适于收集经历消融的组织反射的光的导管，识别并分离所收集的光的组成波长的检测部件，用于产生所收集的光的测量光强度数据的量化装置，以及分析所测量的光的处理器 强度数据与时间有关。 该系统可以包括图形显示和/或音频输出（例如，扬声器），当系统推断组织中的蒸汽口袋的形成时，提供视觉和/或音频报警。 在消融期间监测蒸汽袋形成的方法，其中分析测量的反射光谱强度MRSI与时间的关系，包括将光传送到组织，在组织处输送消融能量并测量组织的反射光谱强度，其中观察为 MRSI是否在特定时间段内最初增加，之后MRSI中以指定的速率下降。 如果MRSI没有减少，那么消融能量传递给组织就会持续下去。 然而，如果MRSI在规定时间内以规定的速率下降，则该方法推测形成蒸汽口袋并减少或停止向组织输送烧蚀能量。

    Apparatus and method for monitoring early formation of steam pop during ablation
    4.
    发明授权
    Apparatus and method for monitoring early formation of steam pop during ablation 有权
    用于监测消融期间早期形成蒸汽流的装置和方法

    公开(公告)号：US08641706B2

    公开(公告)日：2014-02-04

    申请号：US13434554

    申请日：2012-03-29

    申请人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    发明人： Chad Allen Lieber ,  Ariel Garcia ,  Shiva Sharareh

    IPC分类号： A61B18/12

    CPC分类号： A61B18/1492 ,  A61B5/0084 ,  A61B18/1233 ,  A61B2017/00061 ,  A61B2017/00066 ,  A61B2017/00123 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666

    摘要： A system for measuring real-time tissue reflection spectral characteristics during ablation includes a catheter for collecting light reflected from tissue undergoing ablation, a detection component for separating constituent wavelengths of the collected light, a quantification apparatus for generating measured light intensity data of the collected light, and a processor for analyzing the data in relation to time. A method for monitoring formation of steam pop during ablation includes delivering light to tissue, delivering ablative energy to the tissue, measuring the reflectance spectral intensity of the tissue, and observing whether the measured reflectance spectral intensity (MRSI) initially increases in a specified time period followed by a decrease at a specified rate. If the MRSI does not decrease, delivery of ablation energy continues. If the MRSI decreases within the specified time at the specified rate, formation of a steam pocket is inferred and delivery of ablative energy is decreased or discontinued.

    摘要翻译： 用于测量消融期间的实时组织反射光谱特性的系统包括用于收集从经历消融的组织反射的光的导管，用于分离所收集的光的组成波长的检测部件，用于产生所收集的光的测量的光强度数据的量化装置 以及用于分析与时间有关的数据的处理器。 用于监测消融期间蒸汽流出形成的方法包括将光传送到组织，向组织输送消融能量，测量组织的反射光谱强度，以及观察测量的反射光谱强度（MRSI）在指定时间段内是否最初增加 其次是以指定的速度下降。 如果MRSI不减少，消融能量的传递将继续下去。 如果MRSI在指定时间内以指定的速率下降，则推断形成蒸汽口袋，并且释放能量的传送减少或停止。

    Catheter with multi port tip for optical lesion evaluation
    5.
    发明授权
    Catheter with multi port tip for optical lesion evaluation 有权
    导管多端口用于光学损伤评估

    公开(公告)号：US07662152B2

    公开(公告)日：2010-02-16

    申请号：US11453188

    申请日：2006-06-13

    申请人： Shiva Sharareh ,  Ariel Garcia

    发明人： Shiva Sharareh ,  Ariel Garcia

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1492 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2018/00642 ,  A61B2090/306 ,  A61B2218/002

    摘要： A catheter is adapted to ablate tissue and provide optically-based lesion qualitative and quantitative monitoring, comprising a catheter body and a tip electrode distal the catheter body adapted for ablating tissue, the tip electrode having a shell and an alignment member defining a hollow distal portion therebetween. In accordance with the invention, the catheter further includes a plurality of optical waveguides adapted to transmit optical energy to and from the tip electrode. A distal portion of each waveguide extends through the hollow distal portion and terminates in openings formed in the shell. Advantageously, the alignment member fixedly secures the distal portion of each waveguide against movement relative to the alignment member and the shell.

    摘要翻译： 导管适于消融组织并提供基于光学的损伤定性和定量监测，包括导管主体和适于消融组织的导管主体远端的末端电极，尖端电极具有外壳和限定中空远端部分的对准构件 之间。 根据本发明，导管还包括适于将光能传递到尖端电极和从尖端电极传输光能的多个光波导。 每个波导的远端部分延伸穿过中空的远端部分并且终止于壳体中形成的开口。 有利地，对准构件固定地固定每个波导的远端部分，防止相对于对准构件和壳体移动。

    Catheter with multi port tip for optical lesion evaluation
    6.
    发明申请
    Catheter with multi port tip for optical lesion evaluation 有权
    导管多端口用于光学损伤评估

    公开(公告)号：US20070287998A1

    公开(公告)日：2007-12-13

    申请号：US11453188

    申请日：2006-06-13

    申请人： Shiva Sharareh ,  Ariel Garcia

    发明人： Shiva Sharareh ,  Ariel Garcia

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1492 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2018/00642 ,  A61B2090/306 ,  A61B2218/002

    摘要： A catheter is adapted to ablate tissue and provide optically-based lesion qualitative and quantitative monitoring, comprising a catheter body and a tip electrode distal the catheter body adapted for ablating tissue, the tip electrode having a shell and an alignment member defining a hollow distal portion therebetween. In accordance with the invention, the catheter further includes a plurality of optical waveguides adapted to transmit optical energy to and from the tip electrode. A distal portion of each waveguide extends through the hollow distal portion and terminates in openings formed in the shell. Advantageously, the alignment member fixedly secures the distal portion of each waveguide against movement relative to the alignment member and the shell.

    摘要翻译： 导管适于消融组织并提供基于光学的病变定性和定量监测，包括导管主体和适于消融组织的导管主体远端的末端电极，尖端电极具有外壳和限定中空远端部分的对准构件 之间。 根据本发明，导管还包括适于将光能传递到尖端电极和从尖端电极传输光能的多个光波导。 每个波导的远端部分延伸穿过中空的远端部分并且终止于壳体中形成的开口。 有利地，对准构件固定地固定每个波导的远端部分，防止相对于对准构件和壳体移动。