公开(公告)号：US20070129321A1

公开(公告)日：2007-06-07

申请号：US11506200

申请日：2006-08-18

申请人： Chad Mirkin ,  Rafael Vega ,  Daniel Maspoch ,  Khalid Salaita

发明人： Chad Mirkin ,  Rafael Vega ,  Daniel Maspoch ,  Khalid Salaita

IPC分类号： A61K31/70 ,  A01N43/04

CPC分类号： A61K31/70 ,  B82Y5/00 ,  B82Y30/00 ,  C12N7/00 ,  C12N2770/00011 ,  G01N33/56983 ,  Y10S977/802

摘要： A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

摘要翻译： 一种新颖的配位化学或金属离子结合方法，用于通过包括Dip Pen Nanoithography在内的光刻技术生成的纳米阵列模板上控制病毒颗粒（如TMV）的位点分离和取向。 通过使用许多病毒中固有的表面化学，使用金属离子或无机配位化学来固定个体病毒颗粒，而不需要进行遗传修饰。 由于病毒架构与组成这些阵列的特征之间的大小不匹配，单粒子控制将能够进行涉及病毒的各种研究，这些病毒是微不足道的。 这些包括：单粒子，单细胞感染性研究，材料合成和分子电子学模板等结构的探索，以及旨在了解表面呈现如何影响其生物活性的研究。 这是在单粒子水平上的这种控制的开创性例子，因此在生物系统中商业使用纳米阵列。

公开(公告)号：US07569340B2

公开(公告)日：2009-08-04

申请号：US11506200

申请日：2006-08-18

申请人： Chad A. Mirkin ,  Rafael A. Vega ,  Daniel Maspoch ,  Khalid Salaita

发明人： Chad A. Mirkin ,  Rafael A. Vega ,  Daniel Maspoch ,  Khalid Salaita

IPC分类号： C12Q1/70 ,  C12P1/00 ,  C12N7/00 ,  C12N11/00

CPC分类号： A61K31/70 ,  B82Y5/00 ,  B82Y30/00 ,  C12N7/00 ,  C12N2770/00011 ,  G01N33/56983 ,  Y10S977/802

摘要： A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by lithography including Dip Pen Nanolithography. The surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single particle control enables a wide variety of studies involving viruses that are not possible with microarrays, including single particle, single cell infectivity studies, exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation influences their bioactivity. This is an example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

摘要翻译： 提供了利用配位化学或金属离子结合来控制病毒颗粒的位点分离和取向的纳米阵列模板。 纳米阵列模板通过平版印刷产生，包括Dip Pen Nanoithography。 许多病毒，金属离子或无机配位化学中固有的表面化学物质用于固定单个病毒颗粒，而不需要进行遗传修饰。 单粒子控制可以进行涉及病毒的各种研究，这些研究不可能与微阵列，包括单粒子，单细胞感染性研究，材料合成和分子电子学中的模板等结构的探索，以及旨在了解表面表现如何影响其的研究 生物活性。 这是在单粒子水平上的这种控制的例子，因此在生物系统中商业使用纳米阵列。

公开(公告)号：US20070154714A1

公开(公告)日：2007-07-05

申请号：US11633095

申请日：2006-12-04

申请人： Chad Mirkin ,  Yuhuang Wang ,  Daniel Maspoch

发明人： Chad Mirkin ,  Yuhuang Wang ,  Daniel Maspoch

IPC分类号： B32B9/00 ,  B05D5/00 ,  B05D3/00

CPC分类号： B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L51/0048 ,  Y10S977/742 ,  Y10S977/842 ,  Y10S977/845 ,  Y10S977/938 ,  Y10T428/24479 ,  Y10T428/249948 ,  Y10T428/26 ,  Y10T428/29 ,  Y10T428/2933 ,  Y10T428/2938 ,  Y10T428/2969 ,  Y10T428/30 ,  Y10T428/31

摘要： Methods and articles providing for precise aligning, positioning, shaping, and linking of nanotubes and carbon nanotubes. An article comprising: a solid surface comprising at least two different surface regions including: a first surface region which comprises an outer boundary and which is adapted for carbon nanotube adsorption, and a second surface region which is adapted for preventing carbon nanotube adsorption, the second region forming an interface with the outer boundary of the first region, at least one carbon nanotube which is at least partially selectively adsorbed at the interface. The shape and size of the patterns on the surface and the length of the carbon nanotube can be controlled to provide for selective interfacial adsorption.

摘要翻译： 提供纳米管和碳纳米管的精确对准，定位，成形和连接的方法和制品。 一种制品，包括：包含至少两个不同表面区域的固体表面，包括：包含外边界并适于碳纳米管吸附的第一表面区域和适于防止碳纳米管吸附的第二表面区域，第二表面区域 形成与第一区域的外边界的界面的至少一个碳纳米管，其至少部分地选择性地吸附在界面处。 可以控制表面上的图案的形状和尺寸以及碳纳米管的长度以提供选择性界面吸附。

公开(公告)号：US08080314B2

公开(公告)日：2011-12-20

申请号：US13102962

申请日：2011-05-06

申请人： Chad A. Mirkin ,  Yuhuang Wang ,  Daniel Maspoch

发明人： Chad A. Mirkin ,  Yuhuang Wang ,  Daniel Maspoch

IPC分类号： B32B27/04

CPC分类号： B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L51/0048 ,  Y10S977/742 ,  Y10S977/842 ,  Y10S977/845 ,  Y10S977/938 ,  Y10T428/24479 ,  Y10T428/249948 ,  Y10T428/26 ,  Y10T428/29 ,  Y10T428/2933 ,  Y10T428/2938 ,  Y10T428/2969 ,  Y10T428/30 ,  Y10T428/31

摘要： Methods and articles providing for precise aligning, positioning, shaping, and linking of nanotubes and carbon nanotubes. An article comprising: a solid surface comprising at least two different surface regions including: a first surface region which comprises an outer boundary and which is adapted for carbon nanotube adsorption, and a second surface region which is adapted for preventing carbon nanotube adsorption, the second region forming an interface with the outer boundary of the first region, at least one carbon nanotube which is at least partially selectively adsorbed at the interface. The shape and size of the patterns on the surface and the length of the carbon nanotube can be controlled to provide for selective interfacial adsorption.

公开(公告)号：US20110212300A1

公开(公告)日：2011-09-01

申请号：US13102962

申请日：2011-05-06

申请人： Chad A. MIRKIN ,  Yuhuang Wang ,  Daniel Maspoch

发明人： Chad A. MIRKIN ,  Yuhuang Wang ,  Daniel Maspoch

IPC分类号： B32B3/00 ,  B32B33/00 ,  B82Y30/00

CPC分类号： B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L51/0048 ,  Y10S977/742 ,  Y10S977/842 ,  Y10S977/845 ,  Y10S977/938 ,  Y10T428/24479 ,  Y10T428/249948 ,  Y10T428/26 ,  Y10T428/29 ,  Y10T428/2933 ,  Y10T428/2938 ,  Y10T428/2969 ,  Y10T428/30 ,  Y10T428/31

摘要： Methods and articles providing for precise aligning, positioning, shaping, and linking of nanotubes and carbon nanotubes. An article comprising: a solid surface comprising at least two different surface regions including: a first surface region which comprises an outer boundary and which is adapted for carbon nanotube adsorption, and a second surface region which is adapted for preventing carbon nanotube adsorption, the second region forming an interface with the outer boundary of the first region, at least one carbon nanotube which is at least partially selectively adsorbed at the interface. The shape and size of the patterns on the surface and the length of the carbon nanotube can be controlled to provide for selective interfacial adsorption.

摘要翻译： 提供纳米管和碳纳米管的精确对准，定位，成形和连接的方法和制品。 一种制品，包括：包含至少两个不同表面区域的固体表面，包括：包含外边界并适于碳纳米管吸附的第一表面区域和适于防止碳纳米管吸附的第二表面区域，第二表面区域 形成与第一区域的外边界的界面的至少一个碳纳米管，其至少部分地选择性地吸附在界面处。 可以控制表面上的图案的形状和尺寸以及碳纳米管的长度以提供选择性界面吸附。

公开(公告)号：US20100160182A1

公开(公告)日：2010-06-24

申请号：US11917415

申请日：2006-06-13

申请人： Chad A. Mirkin ,  Rafael A. Vega ,  Daniel Maspoch ,  Clifton Kwang-Fu Shen ,  Joseph J. Kakkassery

发明人： Chad A. Mirkin ,  Rafael A. Vega ,  Daniel Maspoch ,  Clifton Kwang-Fu Shen ,  Joseph J. Kakkassery

IPC分类号： C40B40/00 ,  C40B50/18 ,  C40B40/10 ,  C40B40/12

CPC分类号： C12N11/14 ,  C07K1/1077 ,  C07K16/00 ,  G01N33/54306

摘要： A method for immobilizing unmodified material using a metal-ion approach is provided wherein the material is immobilized on a surface in an active state on surface features coupled with metal-ions.

摘要翻译： 提供了使用金属离子方法固定未改性材料的方法，其中将材料固定在与金属离子偶联的表面特征上处于活性状态的表面上。

公开(公告)号：US07959974B2

公开(公告)日：2011-06-14

申请号：US11633095

申请日：2006-12-04

申请人： Chad A. Mirkin ,  Yuhuang Wang ,  Daniel Maspoch

发明人： Chad A. Mirkin ,  Yuhuang Wang ,  Daniel Maspoch

IPC分类号： B05D5/00

CPC分类号： B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L51/0048 ,  Y10S977/742 ,  Y10S977/842 ,  Y10S977/845 ,  Y10S977/938 ,  Y10T428/24479 ,  Y10T428/249948 ,  Y10T428/26 ,  Y10T428/29 ,  Y10T428/2933 ,  Y10T428/2938 ,  Y10T428/2969 ,  Y10T428/30 ,  Y10T428/31

摘要： Methods and articles providing for precise aligning, positioning, shaping, and linking of nanotubes and carbon nanotubes. An article comprising: a solid surface comprising at least two different surface regions including: a first surface region which comprises an outer boundary and which is adapted for carbon nanotube adsorption, and a second surface region which is adapted for preventing carbon nanotube adsorption, the second region forming an interface with the outer boundary of the first region, at least one carbon nanotube which is at least partially selectively adsorbed at the interface. The shape and size of the patterns on the surface and the length of the carbon nanotube can be controlled to provide for selective interfacial adsorption.

摘要翻译： 提供纳米管和碳纳米管的精确对准，定位，成形和连接的方法和制品。 一种制品，包括：包含至少两个不同表面区域的固体表面，包括：包含外边界并适于碳纳米管吸附的第一表面区域和适于防止碳纳米管吸附的第二表面区域， 形成与第一区域的外边界的界面的至少一个碳纳米管，其至少部分地选择性地吸附在界面处。 可以控制表面上的图案的形状和尺寸以及碳纳米管的长度以提供选择性界面吸附。