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1.发明申请Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof 有权单一病毒颗粒的纳米阵列，其制造和使用的方法和仪器公开(公告)号：US20070129321A1
公开(公告)日：2007-06-07
申请号：US11506200
申请日：2006-08-18
申请人： Chad Mirkin , Rafael Vega , Daniel Maspoch , Khalid Salaita
发明人： Chad Mirkin , Rafael Vega , Daniel Maspoch , Khalid Salaita
CPC分类号： A61K31/70 , B82Y5/00 , B82Y30/00 , C12N7/00 , C12N2770/00011 , G01N33/56983 , Y10S977/802
摘要： A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.
摘要翻译： 一种新颖的配位化学或金属离子结合方法，用于通过包括Dip Pen Nanoithography在内的光刻技术生成的纳米阵列模板上控制病毒颗粒（如TMV）的位点分离和取向。 通过使用许多病毒中固有的表面化学，使用金属离子或无机配位化学来固定个体病毒颗粒，而不需要进行遗传修饰。 由于病毒架构与组成这些阵列的特征之间的大小不匹配，单粒子控制将能够进行涉及病毒的各种研究，这些病毒是微不足道的。 这些包括：单粒子，单细胞感染性研究，材料合成和分子电子学模板等结构的探索，以及旨在了解表面呈现如何影响其生物活性的研究。 这是在单粒子水平上的这种控制的开创性例子，因此在生物系统中商业使用纳米阵列。
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2.发明授权Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof 有权单一病毒颗粒的纳米阵列，其制造和使用的方法和仪器公开(公告)号：US07569340B2
公开(公告)日：2009-08-04
申请号：US11506200
申请日：2006-08-18
申请人： Chad A. Mirkin , Rafael A. Vega , Daniel Maspoch , Khalid Salaita
发明人： Chad A. Mirkin , Rafael A. Vega , Daniel Maspoch , Khalid Salaita
CPC分类号： A61K31/70 , B82Y5/00 , B82Y30/00 , C12N7/00 , C12N2770/00011 , G01N33/56983 , Y10S977/802
摘要： A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by lithography including Dip Pen Nanolithography. The surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single particle control enables a wide variety of studies involving viruses that are not possible with microarrays, including single particle, single cell infectivity studies, exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation influences their bioactivity. This is an example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.
摘要翻译： 提供了利用配位化学或金属离子结合来控制病毒颗粒的位点分离和取向的纳米阵列模板。 纳米阵列模板通过平版印刷产生，包括Dip Pen Nanoithography。 许多病毒，金属离子或无机配位化学中固有的表面化学物质用于固定单个病毒颗粒，而不需要进行遗传修饰。 单粒子控制可以进行涉及病毒的各种研究，这些研究不可能与微阵列，包括单粒子，单细胞感染性研究，材料合成和分子电子学中的模板等结构的探索，以及旨在了解表面表现如何影响其的研究 生物活性。 这是在单粒子水平上的这种控制的例子，因此在生物系统中商业使用纳米阵列。
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公开(公告)号：US20080182079A1
公开(公告)日：2008-07-31
申请号：US11770477
申请日：2007-06-28
申请人： Chad Mirkin , Khalid Salaita
发明人： Chad Mirkin , Khalid Salaita
CPC分类号： G03F7/0002 , Y10S977/849 , Y10S977/855 , Y10S977/856 , Y10S977/857 , Y10S977/888 , Y10T428/24479 , Y10T428/24802
摘要： Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substrate surface to a second compound and removing the first compound while leaving the second compound intact. The resulting hole patterns can be used as templates for either chemical etching of the patterned area of the substrate or metal deposition on the patterned area of the substrate.
摘要翻译： 包括在基底表面上图案化第一化合物的平版印刷和纳米光刻方法，将基底表面的未图案化区域暴露于第二化合物并除去第一化合物同时保留第二化合物。 所得到的孔图案可以用作用于对衬底的图案化区域进行化学蚀刻或在衬底的图案化区域上的金属沉积的模板。
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公开(公告)号：US20070087172A1
公开(公告)日：2007-04-19
申请号：US11480557
申请日：2006-07-05
申请人： Chad Mirkin , Khalid Salaita
发明人： Chad Mirkin , Khalid Salaita
CPC分类号： G03F7/0002 , G01Q80/00 , Y10S438/962 , Y10T428/24802
摘要： Novel phase-separation behavior by a mixture, including binary mixture, of patterning compounds, including alkanethiols, when deposited onto a surface, including a gold surface, using micro and nano-deposition tools such as tip and stamp methods like micro-contact printing (μCP), and Dip-Pen Nanolithography (DPN). This behavior is significantly different than that observed in the bulk. This behavior was demonstrated using three examples of compounds: 16-mercaptohexadecanoic acid (MHA), 1-octadecanethiol (ODT), and CF3(CF2)11(CH2)2SH (PFT). The identity of the resulting segregated structure was confirmed by lateral force microscopy (LFM), and by selective metal-organic coordination chemistry. This phenomenon is exploited to print sub-100 nm wide alkanethiol features via conventional μCP and to form sub-15 nm features using DPN printing, which is below the ultimate resolution of both these techniques. These nano-patterned materials also can serve as templates for constructing more complex architectures.
摘要翻译： 当使用微型和纳米沉积工具（诸如尖端和印模方法，如微接触印刷）沉积到包括金表面在内的表面上时，包括二醇混合物的混合物（包括二醇混合物）的新型相分离行为（包括烷基硫醇） muCP）和Dip Pen Nanoithography（DPN）。 这种行为与大量观察到的显着不同。 使用化合物的三个实例证明了这一行为：16-巯基十六烷酸（MHA），1-十八烷硫醇（ODT）和CF 3 N（CF 2）11 （CH 2）2 SH（PFT）。 通过横向力显微镜（LFM）和选择性金属 - 有机配位化学证实了所得到的分离结构的身份。 这种现象被用于通过常规的muCP打印亚100nm宽的链烷硫醇特征，并且使用DPN印刷形成低于15nm的特征，其低于这两种技术的最终分辨率。 这些纳米图案材料也可以用作构建更复杂结构的模板。
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公开(公告)号：US20060081479A1
公开(公告)日：2006-04-20
申请号：US10520554
申请日：2003-06-07
申请人： Chad Mirkin , Khalid Salaita , Yi Zhang
发明人： Chad Mirkin , Khalid Salaita , Yi Zhang
CPC分类号： C40B60/14 , B01J2219/00387 , B01J2219/00436 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01L3/5027 , B81C1/00111 , B81C1/00714 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C25F1/00 , C40B40/04 , G03F7/0002 , H01L51/0006 , H01L51/0017
摘要： The invention provides a simple and convenient strategy for reducing the dimensions of organic micro- and nanostructures on metal surfaces. By varying electrochemical desorption conditions, organic structures patterned by Dip-Pen Nanolithography or any of the micro-contact printing procedures can be gradually desorbed in a controlled fashion. The electrochemical desorption is initiated at the exterior of the feature and moves inward as a function of time. The desorption process and adsorbate desorption are modified and controlled as a function of substrate morphology, adsorbate head and tail groups, and electrolyte solvent and salt. Different nanostructures made of different adsorbates can be miniaturized based upon judicious selection of adsorbate and supporting electrolyte.
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公开(公告)号：US20080105042A1
公开(公告)日：2008-05-08
申请号：US11690738
申请日：2007-03-23
IPC分类号： G01B5/28
CPC分类号： G03F7/0002
摘要： Massive parallel printing of structures and nanostructures at high speed with high resolution and high quality using two dimensional arrays comprising cantilevers and tip-based transfer of material to a surface. The array is designed so only tips touch the surface. This can be accomplished by long tips and bent cantilevers and alignment. An article comprising: a two-dimensional array of a plurality of cantilevers, wherein the array comprises a plurality of base rows, each base row comprising a plurality of cantilevers, wherein each of the cantilevers comprise tips at the cantilever end away from the base, wherein the number of cantilevers is greater than 250, and wherein the tips have an apex height relative to the cantilever of at least four microns, and a support for the array. Combinatorial arrays and bioarrays can be prepared. The arrays can be manufactured by micromachining methods.
摘要翻译： 以高分辨率和高质量高结构和纳米结构的大规模平行印刷，使用二维阵列，其包括悬臂和基于尖端的材料转移到表面。 该阵列设计为只有尖端触摸表面。 这可以通过长尖端和弯曲的悬臂和对准来实现。 一种制品，包括：多个悬臂的二维阵列，其中所述阵列包括多个基列，每个基列包括多个悬臂，其中每个所述悬臂包括远离所述基座的所述悬臂端处的尖端， 其中所述悬臂的数量大于250，并且其中所述尖端具有相对于至少四微米的所述悬臂的顶点高度，以及所述阵列的支撑。 可以制备组合阵列和生物阵列。 阵列可以通过微加工方法制造。
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公开(公告)号：US08192795B2
公开(公告)日：2012-06-05
申请号：US11770477
申请日：2007-06-28
申请人： Chad A. Mirkin , Khalid Salaita
发明人： Chad A. Mirkin , Khalid Salaita
CPC分类号： G03F7/0002 , Y10S977/849 , Y10S977/855 , Y10S977/856 , Y10S977/857 , Y10S977/888 , Y10T428/24479 , Y10T428/24802
摘要： Lithographic and nanolithographic methods that involve patterning a first compound on a substrate surface, exposing non-patterned areas of the substrate surface to a second compound and removing the first compound while leaving the second compound intact. The resulting hole patterns can be used as templates for either chemical etching of the patterned area of the substrate or metal deposition on the patterned area of the substrate.
摘要翻译： 包括在基底表面上图案化第一化合物的平版印刷和纳米光刻方法，将基底表面的未图案化区域暴露于第二化合物并除去第一化合物同时保留第二化合物。 所得到的孔图案可以用作用于对衬底的图案化区域进行化学蚀刻或在衬底的图案化区域上的金属沉积的模板。
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公开(公告)号：US20080242559A1
公开(公告)日：2008-10-02
申请号：US11727906
申请日：2007-03-28
申请人： Chad A. Mirkin , Seung-Woo Lee , Khalid Salaita
发明人： Chad A. Mirkin , Seung-Woo Lee , Khalid Salaita
IPC分类号： C40B40/10
CPC分类号： C40B50/18 , B01J19/0046 , B01J2219/0038 , B01J2219/00387 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00725 , B82Y30/00 , C40B60/14
摘要： Ultrahigh resolution patterning, preferably carried out by DIP PEN™ nanolithographic printing, can be used to construct peptide and protein nanoarrays with nanometer-level dimensions. The peptide and protein nanoarrays, for example, exhibit almost no detectable nonspecific binding of proteins to their passivated portions. This work demonstrates how DIP PEN™ nanolithographic printing can be used in a method to generate high density protein and peptide patterns, which exhibit bioactivity and virtually no non-specific adsorption. It also shows that one can use AFM-based screening procedures to study the reactivity of the features that comprise such nanoarrays. The method encompasses a wide range of protein and peptide structures including, for example, enzymes and antibodies. Features at or below 300 nm can be achieved. In a preferred embodiment, parallel printing with multipen systems are used.
摘要翻译： 优选通过DIP PEN TM纳米光刻印刷进行的超高分辨率图案可用于构建具有纳米级尺寸的肽和蛋白质纳米阵列。 例如，肽和蛋白质纳米阵列几乎没有显示蛋白质与其钝化部分的可检测的非特异性结合。 这项工作展示了DIP PEN TM纳米光刻印刷如何用于产生高密度蛋白质和肽图案的方法，其显示生物活性并且实际上没有非特异性吸附。 它还显示可以使用基于AFM的筛选程序来研究包含这种纳米阵列的特征的反应性。 该方法包括广泛的蛋白质和肽结构，包括例如酶和抗体。 可以实现300nm以下的特征。 在优选实施例中，使用具有多层系统的平行打印。
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公开(公告)号：US20120297509A1
公开(公告)日：2012-11-22
申请号：US13530006
申请日：2012-06-21
CPC分类号： G03F7/0002
摘要： Massive parallel printing of structures and nanostructures at high speed with high resolution and high quality using two dimensional arrays comprising cantilevers and tip-based transfer of material to a surface. The array is designed so only tips touch the surface. This can be accomplished by long tips and bent cantilevers and alignment. An article comprising: a two-dimensional array of a plurality of cantilevers, wherein the array comprises a plurality of base rows, each base row comprising a plurality of cantilevers, wherein each of the cantilevers comprise tips at the cantilever end away from the base, wherein the number of cantilevers is greater than 250, and wherein the tips have an apex height relative to the cantilever of at least four microns, and a support for the array. Combinatorial arrays and bioarrays can be prepared. The arrays can be manufactured by micromachining methods.
摘要翻译： 以高分辨率和高质量高结构和纳米结构的大规模平行印刷，使用二维阵列，其包括悬臂和基于尖端的材料转移到表面。 该阵列设计为只有尖端触摸表面。 这可以通过长尖端和弯曲的悬臂和对准来实现。 一种制品，包括：多个悬臂的二维阵列，其中所述阵列包括多个基列，每个基列包括多个悬臂，其中每个所述悬臂包括远离所述基座的所述悬臂端处的尖端， 其中所述悬臂的数量大于250，并且其中所述尖端具有相对于至少四微米的所述悬臂的顶点高度，以及所述阵列的支撑。 可以制备组合阵列和生物阵列。 阵列可以通过微加工方法制造。
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公开(公告)号：US08220317B2
公开(公告)日：2012-07-17
申请号：US11690738
申请日：2007-03-23
IPC分类号： G01B5/28
CPC分类号： G03F7/0002
摘要： Massive parallel printing of structures and nanostructures at high speed with high resolution and high quality using two dimensional arrays comprising cantilevers and tip-based transfer of material to a surface. The array is designed so only tips touch the surface. This can be accomplished by long tips and bent cantilevers and alignment. An article comprising: a two-dimensional array of a plurality of cantilevers, wherein the array comprises a plurality of base rows, each base row comprising a plurality of cantilevers, wherein each of the cantilevers comprise tips at the cantilever end away from the base, wherein the number of cantilevers is greater than 250, and wherein the tips have an apex height relative to the cantilever of at least four microns, and a support for the array. Combinatorial arrays and bioarrays can be prepared. The arrays can be manufactured by micromachining methods.
摘要翻译： 以高分辨率和高质量高结构和纳米结构的大规模平行印刷，使用二维阵列，其包括悬臂和基于尖端的材料转移到表面。 该阵列设计为只有尖端触摸表面。 这可以通过长尖端和弯曲的悬臂和对准来实现。 一种制品，包括：多个悬臂的二维阵列，其中所述阵列包括多个基列，每个基列包括多个悬臂，其中每个所述悬臂包括远离所述基座的所述悬臂端处的尖端， 其中所述悬臂的数量大于250，并且其中所述尖端具有相对于至少四微米的所述悬臂的顶点高度，以及所述阵列的支撑。 可以制备组合阵列和生物阵列。 阵列可以通过微加工方法制造。
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