公开(公告)号：US09266076B2

公开(公告)日：2016-02-23

申请号：US12513157

申请日：2007-11-01

申请人： Chang-Jin Kim ,  Jian Gong

发明人： Chang-Jin Kim ,  Jian Gong

IPC分类号： B01F13/00 ,  B01L3/00

CPC分类号： B01F13/0076 ,  B01F13/0071 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/089 ,  B01L2400/0427

摘要： A device for generating droplets includes a substrate comprising a reservoir site configured to hold a liquid and including a first electrode, a droplet creation site including a second electrode, and droplet separation site disposed between the reservoir site and the droplet creation site and containing an electrode. The device includes control circuitry operatively coupled to the first, second, and third electrodes. The control circuitry is configured to measure the fluid volume on the electrodes and independently adjust an applied voltage to increase/decrease the quantity of fluid. The device can move fluid onto the creation site or back onto to the reservoir site. When the fluid volume is at the desired value or range, a driving voltage is delivered to the first and second electrodes to form a new droplet. The device may generate droplets having a uniform or user-defined size smaller than the electrode.

摘要翻译： 用于产生液滴的装置包括：基底，其包括被配置为保持液体并包括第一电极的储存部位，包括第二电极的液滴产生位置和设置在储存器位置和液滴产生位点之间并且包含电极 。 该装置包括可操作地耦合到第一，第二和第三电极的控制电路。 控制电路被配置为测量电极上的流体体积，并独立地调节所施加的电压以增加/减少流体的量。 该设备可以将流体移动到创建现场或返回到油库位置。 当流体体积处于期望值或范围时，驱动电压被传送到第一和第二电极以形成新的液滴。 该装置可产生具有小于电极的均匀或用户限定尺寸的液滴。

公开(公告)号：US20100096266A1

公开(公告)日：2010-04-22

申请号：US12513157

申请日：2007-11-01

申请人： Chang-Jin Kim ,  Jian Gong

发明人： Chang-Jin Kim ,  Jian Gong

IPC分类号： B01F3/08 ,  H04N1/034 ,  B01D57/02

CPC分类号： B01F13/0076 ,  B01F13/0071 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/089 ,  B01L2400/0427

摘要： A device for generating droplets includes a substrate comprising a reservoir site configured to hold a liquid and including a first electrode, a droplet creation site including a second electrode, and droplet separation site disposed between the reservoir site and the droplet creation site and containing an electrode. The device includes control circuitry operatively coupled to the first, second, and third electrodes. The control circuitry is configured to measure the fluid volume on the electrodes and independently adjust an applied voltage to increase/decrease the quantity of fluid. The device can move fluid onto the creation site or back onto to the reservoir site. When the fluid volume is at the desired value or range, a driving voltage is delivered to the first and second electrodes to form a new droplet. The device may generate droplets having a uniform or user-defined size smaller than the electrode.

摘要翻译： 用于产生液滴的装置包括：基底，其包括被配置为保持液体并包括第一电极的储存部位，包括第二电极的液滴产生位置和设置在储存器位置和液滴产生位点之间并且包含电极 。 该装置包括可操作地耦合到第一，第二和第三电极的控制电路。 控制电路被配置为测量电极上的流体体积，并独立地调节所施加的电压以增加/减少流体的量。 该设备可以将流体移动到创建现场或返回到油库位置。 当流体体积处于期望值或范围时，驱动电压被传送到第一和第二电极以形成新的液滴。 该装置可产生具有小于电极的均匀或用户限定尺寸的液滴。

公开(公告)号：US20070023292A1

公开(公告)日：2007-02-01

申请号：US11460188

申请日：2006-07-26

申请人： Chang-Jin Kim ,  Jian Gong

发明人： Chang-Jin Kim ,  Jian Gong

IPC分类号： B03C5/02

CPC分类号： F04B19/006 ,  B01F13/0076 ,  B01L3/502792 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0427

摘要： A printed circuit board based digital or droplet microfluidic system and method for producing such microfluidic system are disclosed. The digital microfluidic device comprises a printed circuit board having a substrate and a plurality of electrode pads disposed on the top surface of the substrate in a rectangular array. A via extends from each electrode pad through the substrate to other locations on the substrate . A dielectric layer is disposed on the electrode pads. Droplets may be manipulated using electrowetting principles and others by applying a voltage to the desired electrodes. Each electrode pad can be controlled directly and independently from the other electrode pads to modify the surface wettability of the dielectric layer in the vicinity of the electrode pad by applying a voltage to the desired electrode pad(s). In this way, droplets may be formed, moved, mixed, and/or divided or other small objects manipulated while in air or immersed in a liquid on the dielectric surface.

摘要翻译： 公开了一种用于生产这种微流体系统的基于印刷电路板的数字或液滴微流体系统和方法。 数字微流体装置包括具有衬底的印刷电路板和以矩形阵列布置在衬底的顶表面上的多个电极焊盘。 通孔从每个电极焊盘穿过衬底延伸到衬底上的其它位置。 电介质层设置在电极焊盘上。 可以使用电润湿原理和其它步骤通过向期望的电极施加电压来操纵液滴。 每个电极焊盘可以直接和独立于其他电极焊盘进行控制，以通过向期望的电极焊盘施加电压来改变电极焊盘附近的电介质层的表面润湿性。 以这种方式，液滴可以被形成，移动，混合和/或分割，或者在空气中被操纵的其它小物体或浸在电介质表面上的液体中。

公开(公告)号：US20120148931A1

公开(公告)日：2012-06-14

申请号：US13325451

申请日：2011-12-14

申请人： Chang-Jin Kim ,  Janet Hur ,  Desheng Meng

发明人： Chang-Jin Kim ,  Janet Hur ,  Desheng Meng

IPC分类号： H01M8/04 ,  H01M8/24

CPC分类号： H01M8/04201 ,  H01M8/04186 ,  H01M8/2455 ,  H01M8/2459 ,  Y02E60/50

摘要： The present invention is directed to a device, and method of operation, for a fuel cell which uses bubble-based pumping to self-pump the fuel to the anode, and a single, common channel separating the anode from the cathode through which a mixed fuel and electrolyte flow. The fuel cell includes a single channel having two of its sides formed by the anode and the cathode, each having a suitable catalyst. A bubble generating region is formed in the anode and cathode reaction area of the channel. A one-way valve is located upstream of the bubble generating region. A vent for venting bubbles is disposed over a portion of the channel downstream of the bubble generating region. The fuel cell may be advantageously used to build miniature fuel cells for miniature electronic devices, or scaled to build larger fuel cells for larger electronic devices.

摘要翻译： 本发明涉及一种用于燃料电池的装置和操作方法，所述燃料电池使用基于气泡的泵送将燃料自身泵送到阳极，以及将阳极与阴极分开的单个公共通道，混合 燃料和电解液流。 燃料电池包括单个通道，其两侧由阳极和阴极形成，每个具有合适的催化剂。 在通道的阳极和阴极反应区域中形成气泡生成区域。 单向阀位于气泡生成区域的上游。 用于排出气泡的排气口设置在气泡生成区域下游的通道的一部分上。 燃料电池可以有利地用于构建用于微型电子设备的微型燃料电池，或者缩放以构建用于较大电子设备的较大燃料电池。

公开(公告)号：US20110171518A1

公开(公告)日：2011-07-14

申请号：US13052596

申请日：2011-03-21

申请人： Bruce Dunn ,  Jeffrey W. Long ,  Debra R. Rolison ,  Henry S. White ,  Fred Wudl ,  Sarah H. Tolbert ,  Chang-Jin Kim

发明人： Bruce Dunn ,  Jeffrey W. Long ,  Debra R. Rolison ,  Henry S. White ,  Fred Wudl ,  Sarah H. Tolbert ,  Chang-Jin Kim

IPC分类号： H01M4/32 ,  H01M4/38 ,  H01M2/02 ,  H01M10/04

CPC分类号： H01M10/0525 ,  H01M4/04 ,  H01M4/244 ,  H01M4/32 ,  H01M4/75 ,  H01M10/0436 ,  H01M10/058 ,  H01M2300/0025 ,  H01M2300/0085 ,  Y10T29/49108

摘要： A three-dimensional electrode structure for use in a battery comprising a porous three-dimensional substrate formed from a first electrically conductive material, an ion-conducting dielectric material disposed on the porous three dimensional substrate, and a second electrically conductive material disposed on the ion-conducting dielectric material, wherein the ion-conducting dielectric material separates the first electrically conductive material from the second electrically conductive material.

摘要翻译： 一种用于电池的三维电极结构，包括由第一导电材料形成的多孔三维基板，设置在多孔三维基板上的离子传导电介质材料和设置在离子上的第二导电材料 导电介电材料，其中所述离子传导电介质材料将所述第一导电材料与所述第二导电材料分离。

公开(公告)号：US07976286B2

公开(公告)日：2011-07-12

申请号：US11814162

申请日：2006-01-23

申请人： Chang-Jin Kim ,  De-Sheng Meng

发明人： Chang-Jin Kim ,  De-Sheng Meng

IPC分类号： F04F1/18 ,  H01M8/00

CPC分类号： F04B19/24 ,  F04B19/006 ,  H01M8/04201 ,  H01M8/1011 ,  Y02E60/523

摘要： A method and device for the pumping of liquids utilizes the directional growth and elimination of gaseous vesicles or bubbles to provide the motive or pumping force. In one embodiment, the pumping device is a microfluidic pumping mechanism having a channel, a bubble generator for generating a plurality of bubbles within the channel, and a venting membrane disposed over a portion of the channel downstream of the bubble generator. A one-way valve or directional resistance feature is positioned upstream of the bubble generator to introduce directional transport of bubbles within the channel. The method and device may be integrated into micro fuel cells with organic liquid fuel such that liberated gaseous bubbles may be utilized to deliver fresh fuel or circulate reusable fuel without any power-consuming components.

摘要翻译： 用于泵送液体的方法和装置利用气泡或气泡的定向生长和消除以提供动力或泵送力。 在一个实施例中，泵送装置是具有通道的微流体泵送机构，用于在通道内产生多个气泡的气泡发生器，以及设置在气泡发生器下游的通道的一部分上的通气膜。 单向阀或方向阻力特征位于气泡发生器的上游，以引导通道内气泡的定向输送。 该方法和装置可以用有机液体燃料集成到微型燃料电池中，使得释放的气泡可用于输送新鲜燃料或循环可重复使用的燃料而没有任何功耗成分。

公开(公告)号：US20090283407A1

公开(公告)日：2009-11-19

申请号：US12465935

申请日：2009-05-14

申请人： Gaurav Jitendra Shah ,  Chang-Jin Kim

发明人： Gaurav Jitendra Shah ,  Chang-Jin Kim

IPC分类号： B03C1/005 ,  B01D57/02

CPC分类号： B03C1/01 ,  B01D57/02 ,  B01D61/427 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0475 ,  B03C1/288 ,  B03C5/026 ,  B03C2201/18 ,  G01N33/54333

摘要： Methods of utilizing magnetic particles or beads (MBs) in droplet-based (or digital) microfluidics are disclosed. The methods may be used in enrichment or separation processes. A first method employs the droplet meniscus to assist in the magnetic collection and positioning of MBs during droplet microfluidic operations. The sweeping movement of the meniscus lifts the MBs off the solid surface and frees them from various surface forces acting on the MBs. A second method uses chemical additives to reduce the adhesion of MBs to surfaces. Both methods allow the MBs on a solid surface to be effectively moved by magnetic force. Droplets may be driven by various methods or techniques including, for example, electrowetting, electrostatic, electromechanical, electrophoretic, dielectrophoretic, electroosmotic, thermocapillary, surface acoustic, and pressure.

摘要翻译： 公开了在基于液滴的（或数字）微流体中使用磁性颗粒或珠粒（MB）的方法。 该方法可用于富集或分离过程。 第一种方法使用液滴弯液面来帮助液滴微流控操作期间MB的磁集合和定位。 半月板的扫掠运动将MB离开固体表面，并将它们从作用在MB上的各种表面力释放出来。 第二种方法使用化学添加剂来减少MB对表面的粘附。 两种方法都可以通过磁力有效地移动固体表面上的MB。 液滴可以通过各种方法或技术来驱动，包括例如电润湿，静电，机电，电泳，介电泳，电渗，热毛细管，表面声和压力。

公开(公告)号：US08883014B2

公开(公告)日：2014-11-11

申请号：US13486777

申请日：2012-06-01

申请人： Wyatt C. Nelson ,  Chang-Jin Kim

发明人： Wyatt C. Nelson ,  Chang-Jin Kim

IPC分类号： C23F1/00 ,  B81C1/00 ,  B01L3/00

CPC分类号： B81C1/00119 ,  B01L3/502707 ,  B01L3/502792 ,  B01L2400/0427 ,  B81B2201/058

摘要： A monolithic fabrication method of parallel-plate electrowetting-on-dielectric (EWOD) chips for digital microfluidics of picoliter droplets is disclosed. Instead of assembling a second substrate to form a top plate, the top plate is generated in situ as a thin-film membrane that forms a monolithic cavity having a gap height on the order of micrometers with excellent accuracy and uniformity. The membrane is embedded with EWOD driving electrodes and confines droplets against the device substrate to perform digital microfluidic operations. Two main attributes of the monolithic architecture that distinguish it from tradition methods are: (i) it enables excellent control of droplet dimensions down to the micrometer scale, and (ii) it does not require the typical alignment and assembly steps of the two plates.

摘要翻译： 公开了一种用于皮秒液滴的数字微流体的平行板电润湿介电（EWOD）芯片的单片制造方法。 代替组装第二基板以形成顶板，顶板作为薄膜膜原位产生，其形成具有高度精确度和均匀性的间隔高度为微米级的单片空腔。 膜被嵌入EWOD驱动电极并且将液滴限制在器件衬底上以执行数字微流控操作。 整体式结构的两个主要特征与传统方法区分开来：（i）它可以很好地控制液滴尺寸，直到微米级，以及（ii）它不需要两个板的典型对准和组装步骤。

公开(公告)号：US08304253B2

公开(公告)日：2012-11-06

申请号：US12090922

申请日：2006-10-19

申请人： Uichong Brandon Yi ,  Peter Patrick De Guzman ,  Wayne Liu ,  Chang-Jin Kim

发明人： Uichong Brandon Yi ,  Peter Patrick De Guzman ,  Wayne Liu ,  Chang-Jin Kim

IPC分类号： B01D57/00 ,  B01L99/00

CPC分类号： B01L3/502 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0427 ,  B01L2400/0469 ,  G01N1/10 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A refill droplet facilitates the extraction of a droplet laterally from a channel in a microfluidic apparatus. Such extraction allows a discrete band of separated particles or solute molecules to be excised from a fluid stream and processed and analyzed separately. An extraction point is located along the length of the channel and includes an EWOD surface or similar microfluidic technology to extract a droplet. An opening in the channel opposite the extraction means is equipped with microfluidic technology to transport a refill droplet to the opening. The refill droplet is moved into the channel or column to occupy the area previously occupied by the extracted droplet. This prevents distortion or mixing of the bands of particles or molecules within the channel and prevents the draining of any portion of the fluidic system.

摘要翻译： 补充液滴有助于从微流体装置中的通道横向提取液滴。 这种提取允许分离的颗粒或溶质分子的离散带从流体流中切除并分开处理和分析。 提取点沿着通道的长度定位并且包括用于提取液滴的EWOD表面或类似的微流体技术。 与提取装置相对的通道中的开口配备有微流体技术以将再填充液滴输送到开口。 再填充液滴移动到通道或柱中以占据先前被提取的液滴占据的区域。 这防止了通道内的颗粒或分子带的变形或混合，并且防止流体系统的任何部分的排出。

公开(公告)号：US08093064B2

公开(公告)日：2012-01-10

申请号：US12465935

申请日：2009-05-14

申请人： Gaurav Jitendra Shah ,  Chang-Jin Kim

发明人： Gaurav Jitendra Shah ,  Chang-Jin Kim

IPC分类号： G01N25/08

CPC分类号： B03C1/01 ,  B01D57/02 ,  B01D61/427 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/161 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0475 ,  B03C1/288 ,  B03C5/026 ,  B03C2201/18 ,  G01N33/54333

摘要： Methods of utilizing magnetic particles or beads (MBs) in droplet-based (or digital) microfluidics are disclosed. The methods may be used in enrichment or separation processes. A first method employs the droplet meniscus to assist in the magnetic collection and positioning of MBs during droplet microfluidic operations. The sweeping movement of the meniscus lifts the MBs off the solid surface and frees them from various surface forces acting on the MBs. A second method uses chemical additives to reduce the adhesion of MBs to surfaces. Both methods allow the MBs on a solid surface to be effectively moved by magnetic force. Droplets may be driven by various methods or techniques including, for example, electrowetting, electrostatic, electromechanical, electrophoretic, dielectrophoretic, electroosmotic, thermocapillary, surface acoustic, and pressure.

摘要翻译： 公开了在基于液滴的（或数字）微流体中使用磁性颗粒或珠粒（MB）的方法。 该方法可用于富集或分离过程。 第一种方法使用液滴弯液面来帮助液滴微流控操作期间MB的磁集合和定位。 半月板的扫掠运动将MB离开固体表面，并将它们从作用在MB上的各种表面力释放出来。 第二种方法使用化学添加剂来减少MB对表面的粘附。 两种方法都可以通过磁力有效地移动固体表面上的MB。 液滴可以通过各种方法或技术来驱动，包括例如电润湿，静电，机电，电泳，介电泳，电渗，热毛细管，表面声和压力。