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1.发明申请公开(公告)号：US20180305419A1
公开(公告)日：2018-10-25
申请号：US15576747
申请日：2016-05-27
申请人： Changiz Taghibiglou , Yu Tian Wang
发明人： Changiz Taghibiglou , Yu Tian Wang
CPC分类号： C07K14/47 , A61K9/0014 , A61K38/08 , A61K38/1709 , A61K38/177 , A61K39/395 , A61P17/08 , A61P17/10 , C07K14/705 , C07K16/18 , C07K2319/10 , C12N5/0625 , C12N2501/998
摘要： The present application provides compositions, methods, and uses of polypeptide or antibody inhibitors of insig-1 ubiquitination for preventing or treating skin diseases or conditions associated with overproduction of sebum, such as acne and seborrhea.
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公开(公告)号：US09127079B2
公开(公告)日：2015-09-08
申请号：US13501645
申请日：2010-10-15
申请人： Yu Tian Wang , Shu Zhang , Changiz Taghibiglou
发明人： Yu Tian Wang , Shu Zhang , Changiz Taghibiglou
IPC分类号： A61K38/10 , C07K17/02 , C12N15/12 , C12N15/63 , A61K39/395 , C12N5/02 , C12N15/85 , A61P25/16 , A61P25/28 , A61P25/00 , C07K7/08 , C12N5/10 , C07K14/47 , A61K9/00 , A61K47/48 , A61K38/00
CPC分类号： A61K38/1709 , A61K9/0019 , A61K38/00 , A61K39/3955 , A61K47/645 , C07K14/4702
摘要： Described herein are isolated polypeptides having phosphatase and tensin homolog (PTEN) inhibitory activity, vectors and cells for the expression thereof and methods for their use in treating diseases associated with cytotoxic stress, such as spinal cord injury, stroke, traumatic brain injury, multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Huntington's disease.
摘要翻译： 本文描述了具有磷酸酶和张力蛋白同源（PTEN）抑制活性的分离的多肽，用于其表达的载体和细胞及其用于治疗与细胞毒性应激相关的疾病如脊髓损伤，中风，创伤性脑损伤，多发性硬化 ，阿尔茨海默病，肌萎缩性侧索硬化（ALS），帕金森病和亨廷顿病。
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3.发明授权公开(公告)号：US11117939B2
公开(公告)日：2021-09-14
申请号：US15576747
申请日：2016-05-27
申请人： Changiz Taghibiglou , Yu Tian Wang
发明人： Changiz Taghibiglou , Yu Tian Wang
IPC分类号： C07K14/47 , A61P17/10 , A61P17/08 , A61K9/00 , A61K38/17 , C07K16/18 , C07K14/705 , A61K39/395 , A61Q19/00 , A61K8/64 , C12N5/071
摘要： The present application provides compositions, methods, and uses of polypeptide or antibody inhibitors of insig-1 ubiquitination for preventing or treating skin diseases or conditions associated with overproduction of sebum, such as acne and seborrhea.
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4.发明申请Inhibitors of Phosphatase and Tensin Homolog (PTEN) Compositions, Uses and Methods 有权磷酸酶和凝集素同源物（PTEN）组合物，用途和方法的抑制剂公开(公告)号：US20120269829A1
公开(公告)日：2012-10-25
申请号：US13501645
申请日：2010-10-15
申请人： Yu Tian Wang , Shu Zhang , Changiz Taghibiglou
发明人： Yu Tian Wang , Shu Zhang , Changiz Taghibiglou
IPC分类号： A61K38/10 , C07K17/02 , C12N15/12 , C12N15/63 , A61K39/395 , C12N5/02 , C12N15/85 , A61P25/16 , A61P25/28 , A61P25/00 , C07K7/08 , C12N5/10
CPC分类号： A61K38/1709 , A61K9/0019 , A61K38/00 , A61K39/3955 , A61K47/645 , C07K14/4702
摘要： Described herein are isolated polypeptides having phosphatase and tensin homolog (PTEN) inhibitory activity, vectors and cells for the expression thereof and methods for their use in treating diseases associated with cytotoxic stress, such as spinal cord injury, stroke, traumatic brain injury, multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Huntington's disease.
摘要翻译： 本文描述了具有磷酸酶和张力蛋白同源（PTEN）抑制活性的分离的多肽，用于其表达的载体和细胞及其用于治疗与细胞毒性应激相关的疾病如脊髓损伤，中风，创伤性脑损伤，多发性硬化 ，阿尔茨海默病，肌萎缩性侧索硬化（ALS），帕金森病和亨廷顿病。
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公开(公告)号：US09486472B2
公开(公告)日：2016-11-08
申请号：US13066700
申请日：2011-04-22
申请人： Yu Tian Wang , Yushan Wang , Anthony Phillips , Lidong Liu , Yitao Liu
发明人： Yu Tian Wang , Yushan Wang , Anthony Phillips , Lidong Liu , Yitao Liu
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , C07K7/06 , A61K31/7088 , C07K14/705 , C12N9/12
CPC分类号： A61K31/7088 , A61K38/00 , C07K7/06 , C07K14/705 , C12N9/1205 , G01N2333/705 , G01N2500/02 , G01N2500/04
摘要： Methods and compositions for treating neurological damage or dysfunction are described, including methods implemented by administration of peptide inhibitors of AMPA receptor endocytosis.
摘要翻译： 描述了用于治疗神经损伤或功能障碍的方法和组合物，包括通过施用AMPA受体内吞作用的肽抑制剂实施的方法。
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公开(公告)号：US20120077751A1
公开(公告)日：2012-03-29
申请号：US13066700
申请日：2011-04-22
申请人： Yu Tian Wang , Yushan Wang , Anthony Phillips , Lidong Liu , Yitao Liu
发明人： Yu Tian Wang , Yushan Wang , Anthony Phillips , Lidong Liu , Yitao Liu
CPC分类号： A61K31/7088 , A61K38/00 , C07K7/06 , C07K14/705 , C12N9/1205 , G01N2333/705 , G01N2500/02 , G01N2500/04
摘要： The invention provides, in part, methods and reagents for modulating neuronal apoptosis and for modulating synaptic plasticity.
摘要翻译： 本发明部分地提供了用于调节神经元凋亡和调节突触可塑性的方法和试剂。
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公开(公告)号：US20100048653A1
公开(公告)日：2010-02-25
申请号：US11995494
申请日：2006-07-14
申请人： Yu Tian Wang , Yitao Liu , Tak Pan Wong , Lidong Liu
发明人： Yu Tian Wang , Yitao Liu , Tak Pan Wong , Lidong Liu
IPC分类号： A61K31/42 , A61K31/195
CPC分类号： A61K31/155 , A61K31/223 , A61K31/4164 , A61K31/436 , A61K31/445
摘要： In various aspects, the invention provides methods and compositions for modulating NMDA receptor subtype activity, to enhance NR2A-containing NMDA receptor activity relative to NR2B-containing NMDA receptor activity, so as to effect a neuroprotective reduction in excitotoxic NMDA receptor activity
摘要翻译： 在各个方面，本发明提供用于调节NMDA受体亚型活性的方法和组合物，以相对于含有NR2B的NMDA受体活性增强含NR2A的NMDA受体活性，从而实现兴奋性毒性NMDA受体活性的神经保护性降低
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