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    Interstitial heating of tissue
    2.
    发明授权
    Interstitial heating of tissue 失效
    组织间质加热

    公开(公告)号：US5545195A

    公开(公告)日：1996-08-13

    申请号：US283986

    申请日：1994-08-01

    申请人： Charles D. Lennox ,  Troy W. Roberts

    发明人： Charles D. Lennox ,  Troy W. Roberts

    IPC分类号： A61F7/00 ,  A61B17/22 ,  A61B17/34 ,  A61B18/08 ,  A61F7/12 ,  G01R33/28

    CPC分类号： A61F7/123 ,  A61B17/3415 ,  A61B18/082 ,  A61B2017/22062 ,  A61F2007/126 ,  G01R33/285

    摘要： An elongated, rigid implement having a sharp distal end is insertable into a solid mass within the body of a living being through a puncture site in the solid mass created by the sharp distal end. An elongated sleeve, which engages the elongated, rigid implement, is insertable into the solid mass through the puncture site in the solid mass. Fluid is provided to an expandable chamber located in the vicinity of a distal end of the elongated sleeve through at least one channel located within the elongated sleeve, to inflate the chamber while the chamber is positioned interstitially within the solid mass. A heating device located within the expandable chamber is powered, through at least one elongated conductor located within the elongated sleeve, to heat fluid within the chamber while the chamber is filled with the fluid and is positioned interstitially within the solid mass. The inflation of the chamber while the chamber is positioned interstitially within the solid mass causes compressive ischemia of tissue surrounding the chamber, and the compressive ischemia of the tissue surrounding the chamber reduces a heat sink effect of the tissue during powering of the heating device.

    摘要翻译： 具有尖锐远端的细长刚性器具可通过尖锐远端产生的固体块中的穿刺部位插入生物体内的固体块体内。 与细长刚性器具接合的细长套筒可通过固体块中的穿刺部位插入固体块体中。 通过位于细长套筒内的至少一个通道将流体提供到位于细长套管远端附近的可扩张腔室，以在腔室间歇地固定在固体块内时使腔室膨胀。 位于可扩张室内的加热装置通过位于细长套管内的至少一个细长导体来供电，以在室内充满流体的同时加热腔室内的流体，并且将空间位于固体块内。 腔室间歇地置于固体物质内的腔室的膨胀导致围绕腔室的组织的压缩缺血，并且围绕腔室的组织的压缩性缺血减少了加热装置供电期间组织的散热效应。

    Electro-surgical tissue removal
    4.
    发明授权
    Electro-surgical tissue removal 失效
    电手术组织切除

    公开(公告)号：US5919191A

    公开(公告)日：1999-07-06

    申请号：US794209

    申请日：1997-01-30

    申请人： Charles D. Lennox ,  Stephen F. Moreci ,  Troy W. Roberts

    发明人： Charles D. Lennox ,  Stephen F. Moreci ,  Troy W. Roberts

    IPC分类号： A61B17/32 ,  A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/14 ,  A61M1/00 ,  A61B17/39

    CPC分类号： A61B18/14 ,  A61B18/1482 ,  A61B18/149 ,  A61B18/1402 ,  A61B2017/00274 ,  A61B2018/00178 ,  A61B2018/00196 ,  A61B2018/00547 ,  A61B2018/00607 ,  A61B2018/00738 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1472 ,  A61B2018/1861 ,  A61B2218/002

    摘要： The invention features a bipolar electro-surgical apparatus having a first electrode that has a relatively large surface area for creating a diffuse current sufficient to heat a region of tissue to coagulation temperatures and a second electrode that has a relatively small surface area for creating a concentrated current region sufficient to heat tissue adjacent to the second electrode to resection temperatures. The first and second electrodes are relatively positioned along a treatment path, such that tissue is coagulated and resected as the electro-surgical apparatus is disposed along the path. The invention also features a method for bipolar electro-surgical tissue removal including positioning a pair of bipolar electrodes along a treatment path, flushing the treatment path with an ionic fluid, and imposing a voltage differential to cause current to flow through tissue between the electrodes, where the current flowing through the tissue is sufficient to heat and cause coagulation of the tissue. The invention also features a method for bipolar electro-surgical tissue removal including attaching a power connector adaptor to a resectoscope that is configured for use with a monopolar electro-surgical device and inserting a bipolar electro-surgical device having bipolar electrodes into a working channel of the resectoscope, where the bipolar electro-surgical device is sized to fit within the working channel. The method further including electrically coupling the bipolar electrodes to the power connector adaptor.

    摘要翻译： 本发明的特征在于具有第一电极的双极电手术装置，所述第一电极具有相对较大的表面积，用于产生足以加热组织区域至凝固温度的扩散电流，以及具有相对较小表面积的第二电极以产生集中 当前区域足以将邻近第二电极的组织加热至切除温度。 第一和第二电极沿着治疗路径相对定位，使得当电手术装置沿着路径设置时，组织被凝结和切除。 本发明还涉及一种用于双极电外科组织去除的方法，包括沿着治疗路径定位一对双极电极，用离子流体冲洗治疗路径，并施加电压差以使电流流过电极之间的组织， 其中流过组织的电流足以加热并引起组织的凝结。 本发明还涉及一种用于双极电手术组织去除的方法，包括将电源连接器适配器连接到配置为与单极电手术装置一起使用并且将具有双极电极的双极电手术装置插入到工作通道 其中双极电手术装置的尺寸适合于工作通道。 该方法还包括将双极电极电耦合到电源连接器适配器。

    Ablation catheters
    5.
    发明授权
    Ablation catheters 失效
    消融导管

    公开(公告)号：US5571088A

    公开(公告)日：1996-11-05

    申请号：US471647

    申请日：1995-06-06

    申请人： Charles D. Lennox ,  Susan M. Ropiak ,  Troy W. Roberts ,  Stephen P. Beaudet

    发明人： Charles D. Lennox ,  Susan M. Ropiak ,  Troy W. Roberts ,  Stephen P. Beaudet

    IPC分类号： A61B8/12 ,  A61B17/00 ,  A61B17/22 ,  A61B18/14 ,  A61B19/00 ,  A61M25/00

    CPC分类号： A61B8/12 ,  A61B18/1492 ,  A61B8/445 ,  A61B8/4461 ,  A61B17/2202 ,  A61B2017/00243 ,  A61B2017/00924 ,  A61B2017/22051 ,  A61B2017/22077 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00273 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2034/2063

    摘要： A balloon catheter is provided that includes a catheter shaft constructed for insertion into a blood vessel, an inflatable balloon mounted on a distal portion of the catheter shaft, a heating device mounted on the distal portion of the catheter arranged for heating tissue in contact with the balloon while the balloon is inflated, and an ablation electrode. The catheter shaft and the balloon are sized and constructed to permit the distal portion of the catheter shaft to be inserted into an atrium or ventricle of a heart while the balloon is deflated. The distal portion of the catheter is positioned within the atrium or ventricle and adjacent to a wall of the atrium or ventricle. The balloon is inflated with fluid while the balloon is within the atrium or ventricle, and while the balloon is inflated it is engaged in direct contact with a wall of the atrium or ventricle. Tissue surrounding the balloon is heated through use of the heating device while the balloon is inflated. In one embodiment the balloon disposed is annularly around a distal tip of the catheter shaft, and the electrode is located on the distal tip of the catheter for directly contacting tissue while the balloon is pressed against the tissue in an axial direction. In other embodiments, a suction port is located at the distal tip of the catheter, and a tissue-engagement device surrounds the distal port and is constructed to engage tissue with suction when the port is placed adjacent to the tissue.

    摘要翻译： 提供了一种气囊导管，其包括构造成用于插入血管的导管轴，安装在导管轴的远端部分上的可充气气囊，安装在导管的远端部分上的加热装置，其布置成用于加热与 气球膨胀时，还有消融电极。 导管轴和气囊的尺寸和构造被设计成允许导管轴的远端部分插入到心脏的心房或心室中，同时气囊被放气。 导管的远端部分位于心房或心室内并且邻近心房或心室的壁。 当气囊在心房或心室内时，球囊充满流体，而当球囊膨胀时，其与心房或心室的壁直接接触。 气囊膨胀时，通过使用加热装置来加热围绕气球的组织。 在一个实施例中，设置的气囊围绕导管轴的远侧末端环形，并且电极位于导管的远侧末端，用于在气囊沿轴向压靠组织时直接接触组织。 在其他实施例中，吸入口位于导管的远端，并且组织接合装置围绕远端口并被构造成当端口邻近组织放置时与抽吸接合组织。

    Localized delivery of drug agents
    6.
    发明授权
    Localized delivery of drug agents 有权

    公开(公告)号：US08177743B2

    公开(公告)日：2012-05-15

    申请号：US11107730

    申请日：2005-04-18

    申请人： Charles D. Lennox

    发明人： Charles D. Lennox

    IPC分类号： A61M29/00

    CPC分类号： A61M25/1027 ,  A61F2/07 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1088

    摘要： Medical devices including a substrate that are expandable from a compressed state to an expanded state; a coating on the substrate, the coating having a drug agent incorporated therein; and a sheath over the coating. The sheath is expandable from a compressed state to an expanded state and has at least one perforation therein. The medical devices are configured such that when the substrate is in a compressed state, the sheath is also in a compressed state and the perforation is substantially closed. When the substrate is in an expanded state, the sheath is also in an expanded state and the perforation is substantially open. The invention also includes a method of using the medical devices for the controlled, localized delivery of a drug agent to a target location within a mammalian body.

    Method and device for rapidly inducing and then maintaining hypothermia
    7.
    发明授权
    Method and device for rapidly inducing and then maintaining hypothermia 失效
    快速诱导然后维持低温的方法和装置

    公开(公告)号：US07052509B2

    公开(公告)日：2006-05-30

    申请号：US10706327

    申请日：2003-11-12

    申请人： Charles D. Lennox ,  Steven M. Johnson ,  Susan Beinor ,  Maria Benson ,  Don Paul Nogueira ,  John W. Carroll ,  Helen Maslocka

    发明人： Charles D. Lennox ,  Steven M. Johnson ,  Susan Beinor ,  Maria Benson ,  Don Paul Nogueira ,  John W. Carroll ,  Helen Maslocka

    IPC分类号： A61F7/00

    CPC分类号： A61F7/10 ,  A61F7/0085 ,  A61F2007/0002 ,  A61F2007/0008 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0069 ,  A61F2007/0233

    摘要： A cooling system includes a console and a tissue cooling device such as a head-cooling device. An operator applies the head-cooling device to the head of a patient at risk for ischemic injury. The console provides a cooling fluid to a fluid circulation space located between the cooling device and the patient's head under a positive gage pressure. Direct contact between the cooling fluid and the patient's head provides a relatively rapid induction of systemic hypothermia in the patient, thereby minimizing or preventing ischemic injury in the patient. The console also removes air from a channel disposed about an inner rim of the cooling device, using a negative gage pressure. Such removal of the air from the channel seals the rim of the cooling device to the head of the patient, including portions of the channel in contact with hair of the patient's head, and minimizes leaking of the cooling fluid beyond the rim of the cooling device.

    摘要翻译： 冷却系统包括控制台和诸如头部冷却装置的纸巾冷却装置。 操作者将头部冷却装置应用于患有缺血性损伤风险的患者的头部。 控制台在正面压力下向位于冷却装置和患者头部之间的流体循环空间提供冷却流体。 冷却流体和患者头部之间的直接接触在患者体内提供相对快速的全身低温诱导，从而最小化或预防患者的缺血性损伤。 控制台还使用负量表压力从设置在冷却装置的内缘周围的通道中除去空气。 空气从通道的这种移除将冷却装置的边缘密封到患者的头部，包括与患者头部的头发接触的通道部分，并使冷却流体的泄漏超出冷却装置的边缘 。

    Method and device for rapidly inducing hypothermia
    8.
    发明授权
    Method and device for rapidly inducing hypothermia 失效

    公开(公告)号：US07008445B2

    公开(公告)日：2006-03-07

    申请号：US10424391

    申请日：2003-04-25

    申请人： Charles D. Lennox

    发明人： Charles D. Lennox

    IPC分类号： A61F7/00

    CPC分类号： A61F7/0085 ,  A61F2007/0008 ,  A61F2007/0063 ,  A61F2007/0069 ,  A61F2007/0233

    摘要： Disclosed is a system and method for inducing therapeutic levels of hypothermia in a patient in the emergent care setting. The system consists of a small battery operated console and one or more garments. The garments are connected to the console by one or more umbilicals. The console provides cold fluid to the garments under pressure and the garment cools the surface of the body. Fluid returns from the garment back to the console in a closed loop fashion. The console contains an electrical battery and a thermal battery that provides operation of the system for more than one hour. The cooling capacity of the system is sufficient to induce therapeutic levels of hypothermia in approximately 30 to 90 minutes in most patients. Use of the system does not preclude any therapeutic or diagnostic interventions that are commonly performed in the emergent care setting.

    Deflectable interstitial ablation device
    9.
    发明授权
    Deflectable interstitial ablation device 失效
    可偏转间质消融装置

    公开(公告)号：US06238389B1

    公开(公告)日：2001-05-29

    申请号：US08940519

    申请日：1997-09-30

    申请人： Kimberly A. Paddock ,  James E. Mayberry ,  Charles D. Lennox

    发明人： Kimberly A. Paddock ,  James E. Mayberry ,  Charles D. Lennox

    IPC分类号： A61B1818

    CPC分类号： A61B18/1477 ,  A61B18/1815 ,  A61B2018/00083 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/1425 ,  A61N1/403

    摘要： A deflectable interstitial ablation device includes an elongated housing, an electrode mounted within the elongated housing, a driver coupled to the electrode, an imaging device integrally mounted within the elongated housing and a deflection system disposed within the elongated housing. The elongated housing has a proximal end, a distal end, and a deflectable segment. The electrode is deployable from a first position within the elongated housing to a second position a predetermined distance beyond the distal end of the elongated housing. The electrode further has a flexible portion capable of deflecting with the deflectable segment of the elongated housing, and can be deployed by the driver with a sufficient force such that penetration of the urethral wall occurs in a single motion. The imaging device further has a flexible portion capable of deflecting with the deflectable segment of the elongated housing. The deflection system has a proximal end in communication with a steering mechanism, for controllably deflecting the deflectable segment of the elongated housing by any angle. The deflection of the deflectable segment allows deflection of the electrode and the imaging device, thus facilitating proper placement of the electrode.

    摘要翻译： 可偏转的间质消融装置包括细长壳体，安装在细长壳体内的电极，耦合到电极的驱动器，整体地安装在细长壳体内的成像装置和设置在细长壳体内的偏转系统。 细长的壳体具有近端，远端和可偏转段。 电极可从细长壳体内的第一位置展开至超过细长壳体远端的预定距离的第二位置。 电极还具有能够与细长壳体的可偏转部分偏转的柔性部分，并且可以由驾驶员以足够的力部署，使得尿道壁的穿透以单次运动发生。 成像装置还具有能够与细长壳体的可偏转部分偏转的柔性部分。 偏转系统具有与转向机构连通的近端，用于可控地将细长壳体的可偏转部分偏转任何角度。 可偏转段的偏转允许电极和成像装置偏转，从而有助于电极的正确放置。

    Resecting coagulated tissue
    10.
    发明授权
    Resecting coagulated tissue 失效
    切片凝固组织

    公开(公告)号：US5782848A

    公开(公告)日：1998-07-21

    申请号：US707060

    申请日：1996-09-03

    申请人： Charles D. Lennox

    发明人： Charles D. Lennox

    IPC分类号： A61B17/22 ,  A61B1/00 ,  A61B1/12 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B19/00

    CPC分类号： A61B1/12 ,  A61B17/32002 ,  A61B18/24 ,  A61B2017/320012 ,  A61B2018/0097 ,  A61B2090/373

    摘要： The invention relates to quickly and efficiently removing coagulated tissue within a body lumen without affecting the normal, healthy, untreated tissue, to minimize post-operative complications such as bleeding or edema formation. For example, in an aspect, the invention features a surgical resecting brush assembly. The assembly includes an elongated catheter sized and constructed for delivery through an extended body lumen to a site that is occluded with body matter that has been effected by heat treatment and a brush formation near the distal end of the catheter. The brush formation includes a bristle structure of sufficient stiffness to resect and remove the effected bodily matter without substantially damaging adjacent healthy tissue when the brush formation is actuated relative to the occluded site.

    摘要翻译： 本发明涉及快速且有效地去除体腔内的凝固组织，而不影响正常的，健康的，未经处理的组织，以尽量减少术后并发症，例如出血或水肿形成。 例如，在一方面，本发明的特征在于一种手术切除刷组件。 组件包括细长的导管，其尺寸和构造用于通过延伸的体腔输送到已经通过热处理实现的身体物质的位置和在导管的远端附近的刷子形成。 刷子形成包括具有足够刚度的刷毛结构，以在相对于闭塞部位致动刷子形成时切除并移除受影响的身体物质而基本上不损坏邻近的健康组织。