公开(公告)号：US20070154986A1

公开(公告)日：2007-07-05

申请号：US11563552

申请日：2006-11-27

申请人： Charles Kunsch ,  Gil Choi ,  Patrick Dillon ,  Craig Rosen ,  Steven Barash ,  Michael Fannon ,  Brian Dougherty

发明人： Charles Kunsch ,  Gil Choi ,  Patrick Dillon ,  Craig Rosen ,  Steven Barash ,  Michael Fannon ,  Brian Dougherty

IPC分类号： C12P21/06 ,  C12N1/21 ,  C12N15/74 ,  C07H21/04 ,  C07K14/315

CPC分类号： C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  C07K14/315

摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。

公开(公告)号：US20050181439A1

公开(公告)日：2005-08-18

申请号：US11106649

申请日：2005-04-15

申请人： Gil Choi ,  Charles Kunsch ,  Steven Barash ,  Patrick Dillon ,  Brian Dougherty ,  Michael Fannon ,  Craig Rosen

发明人： Gil Choi ,  Charles Kunsch ,  Steven Barash ,  Patrick Dillon ,  Brian Dougherty ,  Michael Fannon ,  Craig Rosen

IPC分类号： G01N33/53 ,  A01K67/027 ,  A61K38/00 ,  A61K39/00 ,  A61K39/09 ,  A61K48/00 ,  A61P31/04 ,  C07K14/315 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N5/18 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/569 ,  G06F17/30 ,  C07H21/04 ,  C07K14/31 ,  C12N15/74

CPC分类号： C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  C07K14/315

摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.

摘要翻译： 本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。

公开(公告)号：US20070020746A1

公开(公告)日：2007-01-25

申请号：US10807556

申请日：2004-03-24

申请人： Charles Kunsch ,  Gil Choi ,  Steven Barash ,  Patrick Dillon ,  Michael Fannon ,  Craig Rosen

发明人： Charles Kunsch ,  Gil Choi ,  Steven Barash ,  Patrick Dillon ,  Michael Fannon ,  Craig Rosen

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12P21/04 ,  C12N1/20

CPC分类号： C12N15/1093 ,  A61K39/00 ,  C07K14/31 ,  C12N15/52

摘要： The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

摘要翻译： 本发明提供金黄色葡萄球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。

公开(公告)号：US20050043528A1

公开(公告)日：2005-02-24

申请号：US10912362

申请日：2004-08-06

申请人： Gil Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles Kunsch

发明人： Gil Choi ,  Camella Bailey ,  Alex Hromockyj ,  Charles Kunsch

IPC分类号： B82B1/00 ,  A61K39/09 ,  A61P31/04 ,  C07K14/24 ,  C07K14/315 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/566 ,  C07H21/04

CPC分类号： C07K14/24 ,  C07K14/315

摘要： The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

摘要翻译： 本发明涉及来自粪肠球菌的新基因及其编码的多肽。 还提供载体，宿主细胞，抗体及其制备方法。 本发明还涉及用于鉴定粪肠球菌多肽活性的激动剂和拮抗剂的筛选方法。 本发明还涉及在生物样品中检测肠球菌核酸，多肽和抗体的诊断方法。 本发明还涉及用于预防或减轻肠球菌感染的新型疫苗。

公开(公告)号：US20060058268A1

公开(公告)日：2006-03-16

申请号：US11171847

申请日：2005-06-30

申请人： Cynthia Sundell ,  Charles Kunsch

发明人： Cynthia Sundell ,  Charles Kunsch

IPC分类号： A61K31/66 ,  A61K31/192

CPC分类号： A61K31/44 ,  A61K31/192 ,  A61K31/225 ,  A61K31/66

摘要： Compositions and methods of use of compounds of the formula and pharmaceutically acceptable salts thereof for the treatment of diabetic vascular diseases such as diabetic neuropathy, nephropathy, and retinopathy are described, wherein the substituents of the compound are further defined within the application.

摘要翻译： 组合物和形式化合物的使用方法

公开(公告)号：US07247714B2

公开(公告)日：2007-07-24

申请号：US10271429

申请日：2002-10-16

申请人： Charles Kunsch ,  Signe E. Varner ,  Xilin Chen ,  Jayraz Luchoomun

发明人： Charles Kunsch ,  Signe E. Varner ,  Xilin Chen ,  Jayraz Luchoomun

IPC分类号： C07H21/04 ,  C07K1/00 ,  C12Q1/00 ,  C12Q1/68 ,  C12N1/20 ,  C12N15/00

CPC分类号： C07K14/4702

摘要： This invention is in the area of regulatory DNA sequences and their methods of use. Specifically, DNA sequences found in the regulatory region of cytoprotective genes are described that are termed cytoprotective response elements. DNA constructs also are provided that include cytoprotective response elements operably linked to heterologous protein coding sequence, as well as cells and non-human organisms that include the cytoprotective response elements optionally operably linked to a heterologous protein coding sequence, and a method for screening for a compound that increases mRNA or protein regulated by a cytoprotective response element. It has been discovered that the cytoprotective response elements mediate the coordinate activation of certain genes that protect cells from damaging effects of oxidative stress, and that they do so, for example during conditions of hemodynamic shear stress.

摘要翻译： 本发明在调节DNA序列及其使用方法领域。 具体来说，描述了在细胞保护基因的调节区中发现的称为细胞保护反应元件的DNA序列。 还提供了包括可操作地连接到异源蛋白质编码序列的细胞保护反应元件的DNA构建体，以及包括任选可操作地连接到异源蛋白质编码序列的细胞保护反应元件的细胞和非人生物，以及筛选 增加由细胞保护反应元件调节的mRNA或蛋白质的化合物。 已经发现，细胞保护反应元件介导某些保护细胞免受氧化应激影响的基因的配位活化，例如在血液动力学剪切应力的条件下。