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    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting
    5.
    发明授权
    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting 有权
    两性化合物和囊泡脂质体用于器官特异性药物靶向

    公开(公告)号：US07887833B2

    公开(公告)日：2011-02-15

    申请号：US10497705

    申请日：2002-12-04

    申请人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg ,  Victoria Kolot ,  Eleonora Shaubi

    发明人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg ,  Victoria Kolot ,  Eleonora Shaubi

    IPC分类号： A61K9/127 ,  C07C231/00 ,  C07C229/00

    CPC分类号： C07D401/04 ,  A61K9/1272 ,  C07C219/06 ,  C07C233/36 ,  C07C235/28 ,  C07C237/10 ,  C07D303/46 ,  C07H7/00 ,  C07H15/10 ,  C07H15/26

    摘要： An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.

    摘要翻译： 提供能够形成囊泡或脂质体的两亲化合物，所述两亲化合物具有至少一个含有选择性可切割基团或部分的头基，例如胆碱或苯丙氨酸衍生物的残基，以及至少一个位于所述 头组和/或其附近。 可切割基团或部分在选择性条件下被切割，包括化学，物理或生物环境的变化，并且优选在诸如脑或血液的生物环境中酶促切割。 由所述两亲性化合物制成的囊泡或脂质体适于将治疗物质或诊断剂特异性递送至靶器官或组织，或用于递送用于基因治疗的核酸。

    Nano - and Mesosized Particles Comprising an Inorganic Core, Process and Applications Thereof
    6.
    发明申请
    Nano - and Mesosized Particles Comprising an Inorganic Core, Process and Applications Thereof 有权
    包含无机核的纳米和中尺寸颗粒，其工艺和应用

    公开(公告)号：US20090011002A1

    公开(公告)日：2009-01-08

    申请号：US11813311

    申请日：2006-01-02

    申请人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    发明人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    IPC分类号： A61K9/127 ,  A61K9/14

    CPC分类号： A61K9/1272 ,  A61K9/127 ,  A61K9/1277

    摘要： Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.

    摘要翻译： 由包含至少一种无机化合物和/或金属的两亲物和核心的脂质层组成的纳米和中尺寸颗粒的制备方法，包括：（i）在普通溶剂中溶解至少一种自聚集的两亲物 与所述无机化合物或金属的至少一种无机，有机金属或金属有机前体; 和（ii）将所得溶液注入水溶液中或干燥所得溶液并对其进行再水化，以形成其中前体被两亲物包封并在其中转化为所述无机化合物的颗粒， /或金属固体形式。

    Nano- and mesosized particles comprising an inorganic core, process and applications thereof
    7.
    发明授权
    Nano- and mesosized particles comprising an inorganic core, process and applications thereof 有权
    包含无机核的纳米和中尺寸颗粒，其工艺和应用

    公开(公告)号：US08377469B2

    公开(公告)日：2013-02-19

    申请号：US11813311

    申请日：2006-01-02

    申请人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    发明人： Jacob Zabicky ,  Charles Linder ,  Sarina Grinberg ,  Eliahu Heldman

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1272 ,  A61K9/127 ,  A61K9/1277

    摘要： Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.

    摘要翻译： 由包含至少一种无机化合物和/或金属的两亲物和核心的脂质层组成的纳米和中尺寸颗粒的制备方法，包括：（i）在普通溶剂中溶解至少一种自聚集的两亲物 与所述无机化合物或金属的至少一种无机，有机金属或金属有机前体; 和（ii）将所得溶液注入水溶液中或干燥所得溶液并对其进行再水化，以形成其中前体被两亲物包封并在其中转化为所述无机化合物的颗粒， /或金属固体形式。

    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting
    8.
    发明申请
    Amphiphilic compounds and vesicles liposomes for organ-specified drug targeting 有权
    两性化合物和囊泡脂质体用于器官特异性药物靶向

    公开(公告)号：US20060039962A1

    公开(公告)日：2006-02-23

    申请号：US10497705

    申请日：2002-12-04

    申请人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg

    发明人： Eliahu Heldman ,  Charles Linder ,  Sarina Grinberg

    IPC分类号： A61K9/127 ,  C07C237/12

    CPC分类号： C07D401/04 ,  A61K9/1272 ,  C07C219/06 ,  C07C233/36 ,  C07C235/28 ,  C07C237/10 ,  C07D303/46 ,  C07H7/00 ,  C07H15/10 ,  C07H15/26

    摘要： An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.

    摘要翻译： 提供能够形成囊泡或脂质体的两亲化合物，所述两亲化合物具有至少一个含有选择性可切割基团或部分的头基，例如胆碱或苯丙氨酸衍生物的残基，以及至少一个位于所述 头组和/或其附近。 可切割基团或部分在选择性条件下被切割，包括化学，物理或生物环境的变化，并且优选在诸如脑或血液的生物环境中酶促切割。 由所述两亲性化合物制成的囊泡或脂质体适于将治疗物质或诊断剂特异性递送至靶器官或组织，或用于递送用于基因治疗的核酸。

    Method for the preparation of n-propyl bromide
    9.
    发明申请
    Method for the preparation of n-propyl bromide 失效
    正丙基溴的制备方法

    公开(公告)号：US20050065386A1

    公开(公告)日：2005-03-24

    申请号：US10495232

    申请日：2002-11-11

    申请人： Aharon Meirom ,  Arieh Kampf ,  Dmitri Grinberg ,  Mark Grinberg ,  Sarina Grinberg

    发明人： Aharon Meirom ,  Arieh Kampf ,  Dmitri Grinberg ,  Mark Grinberg ,  Sarina Grinberg

    IPC分类号： C07C17/16 ,  C07B61/00 ,  C07C20060101 ,  C07C17/00 ,  C07C17/38 ,  C07C19/075

    CPC分类号： C07C17/16 ,  C07C19/075

    摘要： A method is described for producing n-propyl bromide of a high degree of purity, which contains isopropyl bromide in an amount lower than 0.1% w/w, and usually lower than 0.05%. The method is characterized in that n-propanol is reacted with HBr which is in gas form, preferably dry, and which is in excess over the stoichiometric amount, wherein the excess HBr is at the end of the reaction in an aqueous solution formed from the reaction water. The invention further relates to N-propyl bromide of high purity, containing typically less than 500 ppm of isopropyl bromide.

    摘要翻译： 描述了用于生产高纯度的正丙基溴的方法，该方法含有低于0.1％w / w，通常低于0.05％的异丙基溴。 该方法的特征在于，正丙醇与气体形式的HBr反应，优选干燥，其超过化学计量量，其中过量的HBr在反应结束时在由 反应水。 本发明还涉及高纯度的N-丙基溴，其含有通常小于500ppm的异丙基溴。

    Production of Biodiesel From Balanites Aegyptiaca
    10.
    发明申请
    Production of Biodiesel From Balanites Aegyptiaca 审中-公开
    生物柴油从巴拉尼亚埃及

    公开(公告)号：US20080271364A1

    公开(公告)日：2008-11-06

    申请号：US11915479

    申请日：2006-05-25

    申请人： Zeev Wiesman ,  Mordechay Herskowitz ,  Sarina Grinberg

    发明人： Zeev Wiesman ,  Mordechay Herskowitz ,  Sarina Grinberg

    IPC分类号： C10L1/18

    CPC分类号： C10L1/1802 ,  C10G2300/1011 ,  C10L1/026 ,  C10L10/04 ,  C11C1/08 ,  C11C3/003 ,  Y02E50/13 ,  Y02P30/20

    摘要： The invention provides methods for production of biodiesel from Balanites aegyptiaca oil or crushed nuts, and further relates to the biodiesel obtained. The Balanites aegyptiaca biodiesel obtained has a composition of triglycerides of mainly C16:0 and C18:0 saturated and unsaturated fatty acids, with a very high content of linoleic acid and of oleic acid, and it further contains Balanites saponins, acting as surfactants, which reduce the rate of corrosion and improve the performance of the engyne.

    摘要翻译： 本发明提供了生产来自巴拉尼亚埃及石油或粉碎坚果的生物柴油的方法，并且还涉及获得的生物柴油。 获得的巴拉尼斯aegyptiaca生物柴油具有主要为C16：0和C18：0的饱和和不饱和脂肪酸的甘油三酯的组成，具有非常高的亚油酸含量和油酸含量，并且还含有作为表面活性剂的Balanites皂甙，其中 降低腐蚀速度，提高发动机的性能。