公开(公告)号：US20100221722A1

公开(公告)日：2010-09-02

申请号：US12664869

申请日：2008-06-13

申请人： Charles M. Perou ,  Zhiyuan Hu

发明人： Charles M. Perou ,  Zhiyuan Hu

IPC分类号： C12Q1/68 ,  C12Q1/02

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2800/52

摘要： Methods for diagnosing and for evaluating the prognosis of a cancer patient, particularly a breast cancer patient, are provided. The methods include determining expression levels of at least five biomarkers in a body sample including a cancer cell from the patient, where expression levels of the biomarkers are indicative of cancer prognosis. Overexpression of the biomarkers of the invention is indicative of a poor prognosis. In some embodiments, the body sample is a breast tissue sample, particularly a primary breast tumor sample. The methods of the invention can be used in combination with assessment of conventional clinical factors and permit a more accurate evaluation of breast cancer prognosis.

摘要翻译： 提供了用于诊断和评价癌症患者，特别是乳腺癌患者的预后的方法。 所述方法包括确定体内样品中至少5个生物标志物的表达水平，包括来自患者的癌细胞，其中生物标志物的表达水平指示癌症预后。 本发明的生物标志物的过度表达预示不良预后。 在一些实施方案中，身体样品是乳房组织样品，特别是原发性乳腺肿瘤样品。 本发明的方法可以与常规临床因素的评估结合使用，并能更准确地评估乳腺癌预后。

公开(公告)号：US20110016314A1

公开(公告)日：2011-01-20

申请号：US12736251

申请日：2008-03-25

申请人： Zhiyuan Hu ,  Zhikun Wan ,  Zhigang Luo ,  Ping Huang

发明人： Zhiyuan Hu ,  Zhikun Wan ,  Zhigang Luo ,  Ping Huang

IPC分类号： H04L9/28 ,  H04L9/32

CPC分类号： H04L63/061 ,  H04L9/0844 ,  H04L9/3271 ,  H04L63/164 ,  H04L2463/061 ,  H04W12/04 ,  H04W12/06

摘要： Methods in OMA SEC_CF for providing security services to traffic over UDP between a client and a server and the relevant entities are provided. A pre-shared key is pre-shared between the client and the server. A pair of IPSec ESP SAs between the client and the server is established without shared key negotiation, wherein traffic data cryptographic algorithms are determined. Traffic data security keys are derived from the pre-shared key via the determined traffic data cryptographic algorithms. Then, data of the traffic can be provided with security services with the traffic data security keys through use of IPSec ESP.

摘要翻译： 提供了OMA SEC_CF中用于​​向客户端和服务器以及相关实体之间通过UDP提供安全服务的方法。 预共享密钥在客户端和服务器之间预先共享。 建立客户端与服务器之间的一对IPSec ESP SA，无需共享密钥协商，确定流量数据加密算法。 业务数据安全密钥通过所确定的业务数据密码算法从预共享密钥导出。 然后，可以通过使用IPSec ESP为业务数据提供具有业务数据安全密钥的安全服务。

公开(公告)号：US20070192902A1

公开(公告)日：2007-08-16

申请号：US11655545

申请日：2007-01-19

申请人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

发明人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

IPC分类号： A01H1/00 ,  C07H21/04 ,  C12N15/82 ,  C12N5/04

CPC分类号： C12N15/8234 ,  C07K14/415 ,  C12N15/8247

摘要： The present invention is directed to promoters of flax conlinin and ω-3 desaturase genes. The promoters guide high levels of the expression exclusively in flax developing seeds. This specific expression pattern concomitant with the biosynthesis of storage lipids and proteins make these promoters particularly useful for seed-specific modification of fatty acid and protein compositions in plant seeds.

摘要翻译： 本发明涉及亚麻精蛋白和ω-3去饱和酶基因的启动子。 启动子引导高水平的表达专门在亚麻发育种子。 这种特异性表达模式伴随着储存脂质和蛋白质的生物合成，使得这些启动子特别适用于植物种子中脂肪酸和蛋白质组成的种子特异性修饰。

公开(公告)号：US08307094B2

公开(公告)日：2012-11-06

申请号：US12452641

申请日：2007-07-20

申请人： Ping Huang ,  Zhikun Wan ,  Zhiyuan Hu ,  Xiaorong Jin

发明人： Ping Huang ,  Zhikun Wan ,  Zhiyuan Hu ,  Xiaorong Jin

IPC分类号： G06F15/16

CPC分类号： H04L65/1073 ,  H04L65/1016 ,  H04W8/26 ,  H04W60/04

摘要： The invention provides a method for processing register request, network element, and a communication system. The method for processing a register request of a terminal in a communication system that comprises a first network element (GSN) for providing IP networking service to said terminal, a second network element (P-CSCF) for providing SIP proxy service to said terminal, a third network element (S-CSCF) for providing SIP subscriber service to said terminal, and a fourth network element (HSS) for storing information about said terminal including said terminal's address; wherein the communication system further comprises a fifth network element (NAPT) for translating said terminal's address in between said first network element and said second network element; said method comprise: determining whether a message issued by said terminal for said register request has undergone Network Address Port Translation; indicating an address for address verification in said message based on the determination whether said message has undergone Network Address Port Translation; and verifying the address for address verification in said message against the information stored in said fourth network element.

摘要翻译： 本发明提供了一种处理注册请求，网元和通信系统的方法。 一种用于处理通信系统中的终端的注册请求的方法，该通信系统包括用于向所述终端提供IP联网服务的第一网元（GSN），用于向所述终端提供SIP代理服务的第二网元（P-CSCF） 用于向所述终端提供SIP用户业务的第三网元（S-CSCF）和用于存储关于包括所述终端地址的所述终端的信息的第四网元（HSS） 其中所述通信系统还包括用于在所述第一网络元件和所述第二网络元件之间转换所述终端的地址的第五网络元件（NAPT） 所述方法包括：确定所述终端为所述注册请求发出的消息是否经历了网络地址端口转换; 基于所述消息是否已经经历了网络地址端口转换的确定，指示所述消息中的地址验证地址; 以及根据存储在所述第四网络元件中的信息来验证所述消息中的地址验证的地址。

公开(公告)号：US20090172835A1

公开(公告)日：2009-07-02

申请号：US12336184

申请日：2008-12-16

申请人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

发明人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

IPC分类号： A01H1/00 ,  C07H21/00 ,  C12N15/63 ,  C12N5/04 ,  C12P21/00 ,  A01H5/00

CPC分类号： C12N15/8234 ,  C07K14/415 ,  C12N15/8247

摘要： The present invention is directed to promoters of flax conlinin and ω-3 desaturase genes. The promoters guide high levels of the expression exclusively in flax developing seeds. This specific expression pattern concomitant with the biosynthesis of storage lipids and proteins make these promoters particularly useful for seed-specific modification of fatty acid and protein compositions in plant seeds.

摘要翻译： 本发明涉及亚麻精蛋白和ω-3去饱和酶基因的启动子。 启动子引导高水平的表达专门在亚麻发育种子。 这种特异性表达模式伴随着储存脂质和蛋白质的生物合成，使得这些启动子特别适用于植物种子中脂肪酸和蛋白质组成的种子特异性修饰。

公开(公告)号：US07193134B2

公开(公告)日：2007-03-20

申请号：US10165289

申请日：2002-06-06

申请人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

发明人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

IPC分类号： C12N15/29 ,  C12N15/52 ,  C12N15/63 ,  C12N15/82 ,  A01H1/00

CPC分类号： C12N15/8234 ,  C07K14/415 ,  C12N15/8247

摘要： The present invention is directed to promoters of flax conlinin and ω-3 desaturase genes. The promoters guide high levels of the expression exclusively in flax developing seeds. This specific expression pattern concomitant with the biosynthesis of storage lipids and proteins make these promoters particularly useful for seed-specific modification of fatty acid and protein compositions in plant seeds.

摘要翻译： 本发明涉及亚麻精蛋白和ω-3去饱和酶基因的启动子。 启动子引导高水平的表达专门在亚麻发育种子。 这种特异性表达模式伴随着储存脂质和蛋白质的生物合成，使得这些启动子特别适用于植物种子中脂肪酸和蛋白质组成的种子特异性修饰。

公开(公告)号：US09794831B2

公开(公告)日：2017-10-17

申请号：US13505049

申请日：2009-10-30

申请人： Zhengxiong Lei ,  Xueqiang Yan ,  Zhiyuan Hu ,  Yonggen Wan

发明人： Zhengxiong Lei ,  Xueqiang Yan ,  Zhiyuan Hu ,  Yonggen Wan

IPC分类号： H04W36/00 ,  H04L29/06

CPC分类号： H04W36/0022 ,  H04L65/1016 ,  H04L65/1083 ,  H04L65/80

摘要： The present invention provides a method for shortening signaling delay of ISC session transfer procedure, a network element for controlling ISC session transfer, a network element for anchoring a media path in ISC session transfer and a communication system including at least two terminals and the above two network elements. In the present invention, the SCC AS decides if a media path needs to be anchored in a media anchor point MRF, and if yes, then instructs a MRF to assign respective media endpoints for a local UE and a remote UE and connect the two media endpoints together, so as to divide the session between the local UE and the remote UE into two independent sub-sessions: a session between the local UE and the MRF, and a session between the remote UE and the MRF. For these two sub-sessions, the SIP signaling is terminated and sent out in the SCC AS. Thus, when a local UE or a remote UE triggers handover, only one sub-session needs to be updated/influenced.

公开(公告)号：US20100174819A1

公开(公告)日：2010-07-08

申请号：US12452641

申请日：2007-07-20

申请人： Ping Huang ,  Zhikun Wan ,  Zhiyuan Hu ,  Xiaorong Jin

发明人： Ping Huang ,  Zhikun Wan ,  Zhiyuan Hu ,  Xiaorong Jin

IPC分类号： G06F15/16

CPC分类号： H04L65/1073 ,  H04L65/1016 ,  H04W8/26 ,  H04W60/04

摘要： The invention provides a method for processing register request, network element, and a communication system. The method for processing a register request of a terminal in a communication system that comprises a first network element (GSN) for providing IP networking service to said terminal, a second network element (P-CSCF) for providing SIP proxy service to said terminal, a third network element (S-CSCF) for providing SIP subscriber service to said terminal, and a fourth network element (HSS) for storing information about said terminal including said terminal's address; wherein the communication system further comprises a fifth network element (NAPT) for translating said terminal's address in between said first network element and said second network element; said method comprise: determining whether a message issued by said terminal for said register request has undergone Network Address Port Translation; indicating an address for address verification in said message based on the determination whether said message has undergone Network Address Port Translation; and verifying the address for address verification in said message against the information stored in said fourth network element.

摘要翻译： 本发明提供一种处理注册请求，网元和通信系统的方法。 一种用于处理通信系统中的终端的注册请求的方法，该通信系统包括用于向所述终端提供IP联网服务的第一网元（GSN），用于向所述终端提供SIP代理服务的第二网元（P-CSCF） 用于向所述终端提供SIP用户业务的第三网元（S-CSCF）和用于存储关于包括所述终端地址的所述终端的信息的第四网元（HSS） 其中所述通信系统还包括用于在所述第一网络元件和所述第二网络元件之间转换所述终端的地址的第五网络元件（NAPT） 所述方法包括：确定所述终端为所述注册请求发出的消息是否经历了网络地址端口转换; 基于所述消息是否已经经历了网络地址端口转换的确定，指示所述消息中的地址验证地址; 以及根据存储在所述第四网络元件中的信息来验证所述消息中的地址验证的地址。

公开(公告)号：US08841512B2

公开(公告)日：2014-09-23

申请号：US12336184

申请日：2008-12-16

申请人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

发明人： Xiao Qiu ,  Martin Truksa ,  Zhiyuan Hu

IPC分类号： C12N15/82 ,  A01H5/00 ,  C12N5/10 ,  C07H21/04 ,  C07K14/415

CPC分类号： C12N15/8234 ,  C07K14/415 ,  C12N15/8247

摘要： The present invention is directed to promoters of flax conlinin and ω-3 desaturase genes. The promoters guide high levels of the expression exclusively in flax developing seeds. This specific expression pattern concomitant with the biosynthesis of storage lipids and proteins make these promoters particularly useful for seed-specific modification of fatty acid and protein compositions in plant seeds.

摘要翻译： 本发明涉及亚麻精蛋白和ω-3去饱和酶基因的启动子。 启动子引导高水平的表达专门在亚麻发育种子。 这种特异性表达模式伴随着储存脂质和蛋白质的生物合成，使得这些启动子特别适用于植物种子中脂肪酸和蛋白质组成的种子特异性修饰。

公开(公告)号：US08632982B2

公开(公告)日：2014-01-21

申请号：US12785279

申请日：2010-05-21

申请人： Zhiyuan Hu ,  Christopher Lausted ,  Leroy Hood

发明人： Zhiyuan Hu ,  Christopher Lausted ,  Leroy Hood

IPC分类号： G01N33/53 ,  C07K16/00

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N2800/085

摘要： Fourteen markers not previously known to be associated with liver injury have been identified. Methods to diagnose a subject for liver injury using these markers are described.

摘要翻译： 已经鉴定了以前未知与肝损伤相关的14个标记。 描述了使用这些标记物诊断受试者肝损伤的方法。