公开(公告)号：US20070128611A1

公开(公告)日：2007-06-07

申请号：US11292588

申请日：2005-12-02

申请人： Charles Nelson ,  Bo Curry ,  Nicholas Sampas

发明人： Charles Nelson ,  Bo Curry ,  Nicholas Sampas

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6876 ,  C12Q1/6813 ,  C12Q2600/166 ,  G16B25/00 ,  G16B30/00 ,  C12Q2545/101

摘要： In an embodiment, a method is included for generating a negative control probe sequence for an array including selecting biological probe sequences from the array randomly, generating a plurality of candidate probe sequences by randomly permuting the selected biological probe sequence, and screening the candidate probe sequences for sequence similarity to biologically occurring sequences. An embodiment also includes a computer-readable medium having computer-executable instructions for performing a method for generating a negative control probe sequences. Embodiments can also include an apparatus for generating a negative control sequence for an array, as well as negative control probes, sets of negative control probes and arrays comprising at least one negative control probe.

摘要翻译： 在一个实施方案中，包括用于产生用于阵列的阴性对照探针序列的方法，包括随机选择阵列中的生物探针序列，通过随机置换所选生物探针序列产生多个候选探针序列，并筛选候选探针序列 与生物发生序列的序列相似性。 实施例还包括具有用于执行生成负控制探针序列的方法的计算机可执行指令的计算机可读介质。 实施例还可以包括用于产生阵列的负控制序列的装置，以及阴性对照探针，负控制探针组和包括至少一个阴性对照探针的阵列。

公开(公告)号：US20070067110A1

公开(公告)日：2007-03-22

申请号：US11232817

申请日：2005-09-21

申请人： Charles Nelson ,  Nicholas Sampas ,  Bo Curry

发明人： Charles Nelson ,  Nicholas Sampas ,  Bo Curry

IPC分类号： G06F19/00

CPC分类号： C12Q1/6876 ,  C12Q2600/166 ,  G16B25/00 ,  G16B30/00

摘要： The invention relates to methods and systems for generating negative controls for arrays. In an embodiment, the invention includes a method for generating a negative control probe sequence for an array including randomly generating a plurality of candidate negative control probes, screening the candidate negative control probes for sequence similarity to biologically occurring sequences, and screening the candidate negative control probes for one or more of base composition properties, primary structural features, secondary structural features, or thermodynamic characteristics. In an embodiment, the invention includes an apparatus for generating a negative control sequence for an array. The apparatus including a memory store and a programmable circuit in electrical communication with the memory store, the programmable circuit programmed to randomly generate a plurality of candidate probe sequences, screen the candidate probe sequences for sequence similarity to biologically occurring sequences, and screen the candidate probe sequences for one or more of base composition properties, primary structural features, secondary structural features, or thermodynamic characteristics.

摘要翻译： 本发明涉及用于产生阵列的负控制的方法和系统。 在一个实施方案中，本发明包括用于产生阵列的阴性对照探针序列的方法，包括随机产生多个候选阴性对照探针，筛选候选阴性对照探针以获得与生物学发生序列的序列相似性，以及筛选候选阴性对照 基础组合物性质，初级结构特征，二级结构特征或热力学特性中的一种或多种的探针。 在一个实施例中，本发明包括用于产生阵列的负控制序列的装置。 所述装置包括存储器存储器和与存储器存储器电通信的可编程电路，所述可编程电路被编程为随机生成多个候选探针序列，将候选探针序列筛选为与生物学发生序列的序列相似性，并筛选候选探针 基础组合物性质，初级结构特征，二级结构特征或热力学特征中的一种或多种的序列。

公开(公告)号：US20080282609A1

公开(公告)日：2008-11-20

申请号：US11840360

申请日：2007-08-17

申请人： Charles Nelson

发明人： Charles Nelson

IPC分类号： A01G25/02

CPC分类号： A01G25/02 ,  A01G13/0268

摘要： Irrigation sheets are disclosed which include a base sheet and one or more tubes extending along the length of the base sheet. Methods of forming and using irrigation sheets are also disclosed.

摘要翻译： 公开了包括基片和沿着基片的长度延伸的一个或多个管的灌注片。 还公开了形成和使用灌注片的方法。

公开(公告)号：US20070233105A1

公开(公告)日：2007-10-04

申请号：US11565534

申请日：2006-11-30

申请人： Charles Nelson ,  Heber Saravia ,  Kai Mazur

发明人： Charles Nelson ,  Heber Saravia ,  Kai Mazur

IPC分类号： A61B17/56

CPC分类号： A61B17/7275 ,  A61B17/7208 ,  A61B17/7241 ,  A61B17/7266 ,  A61B17/7291 ,  A61B2017/00004

摘要： Apparatus for bone reinforcement, fixation and treatment of diseased or fractured bones including a supporting structure optionally coated with therapeutic agent is provided. The supporting structure or device may be collapsible upon deployment at the surgical site, and include fixation features such as anchors to securely position in place once deployed. Bone cement or other material may be provided to alternatively secure the positioned supporting structure for treatment. A lockable bone fixation device is described that comprises: a sleeve adapted to be positioned in a space formed in a bone; a guidewire adapted to guide movement of the sleeve; and an actuable lock adapted to secure the sleeve within the space of the bone from an end of the device.

摘要翻译： 提供了用于骨增强，固定和治疗患病或骨折骨的装置，其包括任选地涂覆有治疗剂的支撑结构。 支撑结构或装置在展开在外科手术部位时可以是可折叠的，并且包括诸如锚固件的固定特征，以便在展开后可靠地定位就位。 可以提供骨水泥或其他材料以交替地固定定位的支撑结构以进行治疗。 描述了一种可锁定的骨固定装置，其包括：适于定位在形成在骨中的空间中的套筒; 适于引导套筒运动的导丝; 以及适于将套筒从装置的端部固定在骨的空间内的致动锁。

公开(公告)号：US20060116827A1

公开(公告)日：2006-06-01

申请号：US11000681

申请日：2004-11-30

申请人： Peter Webb ,  Charles Nelson ,  Amitabh Shukla ,  Marylinn Munson

发明人： Peter Webb ,  Charles Nelson ,  Amitabh Shukla ,  Marylinn Munson

IPC分类号： G06F19/00 ,  G06Q10/00 ,  G06Q50/00

CPC分类号： G06Q50/22 ,  G16B25/00 ,  G16B50/00

摘要： Systems and methods for using the same to obtain a chemical array layout are provided. Also provided are computer program products for executing the subject methods.

公开(公告)号：US20060093819A1

公开(公告)日：2006-05-04

申请号：US11300952

申请日：2005-12-15

申请人： Kenneth Atwood ,  Anne-Marie Coffin ,  John Feathers ,  Richard Hayes ,  Charles Nelson

发明人： Kenneth Atwood ,  Anne-Marie Coffin ,  John Feathers ,  Richard Hayes ,  Charles Nelson

IPC分类号： D02G3/00

CPC分类号： D06N3/04 ,  D01D11/06 ,  D01F8/10 ,  D01F8/14 ,  D06N3/183 ,  Y10T428/2913 ,  Y10T428/2924 ,  Y10T428/2929 ,  Y10T428/2933 ,  Y10T428/2964 ,  Y10T428/2969 ,  Y10T442/2861 ,  Y10T442/641

摘要： The present invention provides monofilaments coated with certain adhesive layers and methods to produce the coated filaments. Also provided are fabrics formed from the monofilaments. The coated monofilaments and fabrics provide improved adhesion with additional coating top layers.

摘要翻译： 本发明提供了涂覆有某些粘合剂层的单丝以及制备涂覆长丝的方法。 还提供了由单丝形成的织物。 涂覆的单丝和织物提供与附加涂层顶层的改善的粘合性。

公开(公告)号：US20050064187A1

公开(公告)日：2005-03-24

申请号：US10980546

申请日：2004-11-03

申请人： Charles Nelson ,  Jayendra Bheda ,  Peter Rim ,  James Turner

发明人： Charles Nelson ,  Jayendra Bheda ,  Peter Rim ,  James Turner

IPC分类号： D01D5/12 ,  D01F6/62 ,  D02G3/00

CPC分类号： D01F6/62 ,  D01D5/12 ,  Y10T428/2913 ,  Y10T428/2969

摘要： A spun polyester fiber, a drawn polyester yarn, and methods for making them. Polyethylene terephthalate yarn is prepared by extruding a molten melt-spinnable polyethylene terephthalate having an intrinsic viscosity of at least about 0.8 through a shaped extrusion orifice having a plurality of openings to form a molten spun yarn; solidifying gradually said molten spun yarn by passing said molten spun yarn through a solidification zone which comprises (i) a retarded cooling zone and (ii) a cooling zone adjacent said retarded cooling zone where, in said cooling zone, said yarn is rapidly cooled and solidified in a gaseous atmosphere; withdrawing at sufficient speed said solidified yarn from said solidification zone to form a crystalline partially oriented yarn; and hot drawing said crystalline partially oriented yarn at a total draw ratio between about 1.5/1 and about 2.5/1 to produce a drawn yarn having an effective crosslink density (N) between about 10×1021 and about 20×1021 crosslinks per cubic centimeter. The yarns and fibers so prepared may be used to make treated tire cord having high tenacity in combination with improved dimensional stability.

摘要翻译： 纺丝聚酯纤维，拉伸聚酯纱线及其制造方法。 聚对苯二甲酸乙二醇酯纱线通过具有多个开口的成型挤出孔挤出特性粘度至少为约0.8的熔融可纺丝聚对苯二甲酸乙二醇酯制成，以形成熔融纺丝纱线; 通过使所述熔融纺丝通过固化区，使熔融纺丝逐渐凝固，所述固化区包括（i）延迟冷却区和（ii）与所述延迟冷却区相邻的冷却区，在所述冷却区中所述纱快速冷却， 在气氛中固化; 以足够的速度从所述固化区抽出所述固化纱线以形成结晶部分取向的纱线; 并且以约1.5 / 1至约2.5 / 1的总拉伸比热拉伸所述结晶部分取向的纱线，以产生具有约10×10 21至约20×10 21交联的有效交联密度（N）的拉伸丝 立方厘米。 如此制备的纱线和纤维可用于制造具有高强度的处理轮胎帘线，同时具有改进的尺寸稳定性。

公开(公告)号：US20130304535A1

公开(公告)日：2013-11-14

申请号：US13940629

申请日：2013-07-12

申请人： David Cheng Hu ,  Charles Nelson ,  Tim Landvoigt ,  James Tarver ,  Claribel Chan

发明人： David Cheng Hu ,  Charles Nelson ,  Tim Landvoigt ,  James Tarver ,  Claribel Chan

IPC分类号： G06Q10/06

CPC分类号： G06Q10/0637 ,  G06Q10/067 ,  G06Q10/10

摘要： Systems and techniques to allow a user to design and manage business solutions. The business solution management system (150) comprises a portal layer (112), an application layer (104) and a data repository (106). The portal layer (112) comprises at least first and second agents (204, 208). The application layer (104) comprises at least first and second software applications (220, 224). The first and second agents (204, 208) provide user interfaces to the first and second software applications (220, 224). The first software application (220) is operable to allow a user to design a business solution with user parameters and user-selectable, pre-defined business process objects and pre-defined technology objects. The second software application (224) is operable to allow a user to manage the business solution. The data repository (106) comprises the pre-defined business objects (316) and pre-defined technology objects (314).

摘要翻译： 允许用户设计和管理业务解决方案的系统和技术。 业务解决方案管理系统（150）包括门户层（112），应用层（104）和数据存储库（106）。 入口层（112）包括至少第一和第二代理（204,208）。 应用层（104）至少包括第一和第二软件应用（220,224）。 第一和第二代理（204,208）向第一和第二软件应用程序（220,224）提供用户界面。 第一软件应用程序（220）可操作以允许用户设计具有用户参数和用户可选择的预定义业务处理对象和预定义技术对象的业务解决方案。 第二软件应用程序（224）可操作以允许用户管理业务解决方案。 数据存储库（106）包括预定义的业务对象（316）和预定义的技术对象（314）。

公开(公告)号：US20070294881A1

公开(公告)日：2007-12-27

申请号：US11825569

申请日：2007-07-06

申请人： Charles Nelson ,  Paul Kikuchi ,  James Vargo ,  Douglas Behrendt ,  Walter Symons ,  William LaBarge ,  Kaius Polikarpus ,  Rick Kerr ,  Jinping Zhang ,  Paul Daniel

发明人： Charles Nelson ,  Paul Kikuchi ,  James Vargo ,  Douglas Behrendt ,  Walter Symons ,  William LaBarge ,  Kaius Polikarpus ,  Rick Kerr ,  Jinping Zhang ,  Paul Daniel

IPC分类号： H01C17/075 ,  H01C17/242

CPC分类号： H01C17/075 ,  G01K7/18 ,  G01K15/00 ,  H01C17/242 ,  Y10T29/49004 ,  Y10T29/49085

摘要： A method for manufacturing a planar sensor, comprises disposing a film of a material on a substrate, wherein the material is selected from the group consisting of platinum, rhodium, palladium and mixtures and alloys comprising at least one of the foregoing materials; annealing the material; measuring a resistance value of the material; laser trimming the annealed material; heat treating the laser trimmed material; and laser trimming the heat treated material to form the sensor.

公开(公告)号：US07270479B2

公开(公告)日：2007-09-18

申请号：US10752402

申请日：2004-01-06

申请人： Charles Nelson

发明人： Charles Nelson

IPC分类号： B65D33/16 ,  B65D33/01

CPC分类号： B65D33/2558 ,  B65B31/00 ,  B65D33/01 ,  B65D33/2516 ,  B65D33/255 ,  B65D2205/00

摘要： A reclosable bag has a bag body and a reclosable, zipper-type closure. The reclosable closure has extruded male and female interlocking profiles extending along opposing sides of an opening of the bag and are constructed to releasably interlock. The closure also has an extruded valve flange extending from one side of the closure to engage an opposing surface of the closure when the profiles are interlocked. The flange and opposing surface are constructed to separate in response to pressure within the bag for venting the bag with the profiles interlocked, and to increase a contact pressure therebetween in response to presence of a vacuum in the bag. The closure also defines a vent passage extending from an air space between the opposing sides of the opening and between the interlocking profiles and the valve flange. In use, the interlocking profiles are engaged to close the bag opening, and then the bag sides are compressed together to force entrapped air out through the vent opening, deflecting the valve flange away from its opposing surface.

摘要翻译： 可重新封闭的袋子具有袋体和可再闭合的拉链型封口。 可重新闭合的封闭件具有挤出的阳和阴互锁型材，其沿着袋的开口的相对侧延伸并且构造成可释放地互锁。 封闭件还具有从封闭件的一侧延伸的挤出阀凸缘，以在型材互锁时与封闭件的相对表面接合。 凸缘和相对表面被构造成响应于袋内的压力而分离，以便使配合物互锁的袋子排出，并且响应于袋中存在真空而增加其间的接触压力。 封闭件还限定了从开口的相对侧之间和互锁型材与阀凸缘之间的空气空间延伸的通气通道。 在使用中，互锁型材被接合以闭合袋开口，然后袋侧面被压缩在一起以迫使截留的空气通过排气口排出，使阀凸缘偏离其相对的表面。