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1.发明申请公开(公告)号：US20090187206A1
公开(公告)日：2009-07-23
申请号：US12174337
申请日：2008-07-16
IPC分类号： A61M29/00
CPC分类号： A61F5/0036 , A61F5/0013 , A61F5/003 , A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61F2210/0019 , A61F2210/009
摘要： The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.
摘要翻译： 本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置。 整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。 在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。 一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。 设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。
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2.发明授权公开(公告)号：US09060835B2
公开(公告)日：2015-06-23
申请号：US12174337
申请日：2008-07-16
CPC分类号： A61F5/0036 , A61F5/0013 , A61F5/003 , A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61F2210/0019 , A61F2210/009
摘要： The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.
摘要翻译： 本发明涉及通过其构象（包括长度和曲率的尺寸）稳定在胃肠道内腔内停留部位的装置。 整个装置对应于居住地点的构造; 更具体地，弯曲或成角度的部分对应于居住部位的弯曲或成角度部分，并且不符合直接近端或远端部位。 在一些实施例中，构象稳定的装置可以影响驻留位置形状的变化，这有助于装置的稳定性。 一些实施例旨在限制食欲和/或减少食物摄取，其他实施方案可以针对其他治疗目的。 设备的一些实施例被设计为完全驻留在十二指肠中; 其他的主要存在于十二指肠内，但是向近端延伸到胃窦内，而其它实施例被设计为驻留在胃肠道内的其他地方。
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公开(公告)号：US08454632B2
公开(公告)日：2013-06-04
申请号：US12427215
申请日：2009-04-21
IPC分类号： A61B17/08
CPC分类号： A61B17/12009 , A61B17/11 , A61B17/1114 , A61B17/3468 , A61B17/3478 , A61B2017/00278 , A61B2017/0034 , A61B2017/1139 , A61B2017/3486 , A61F2/82 , A61M25/1002 , A61M2025/0096 , A61M2025/09125 , A61M2025/1059
摘要： Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.
摘要翻译： 组织锚固件包括编织长丝编织体，其具有细长的管状构造和缩短构型，其中主体的近端和远端径向扩展成双壁凸缘结构，同时在其间留下圆柱形鞍形区域。 组织锚固件通过相邻组织层之间的穿透进行展开，其中凸缘接合组织层的外表面，并且鞍形区域位于组织穿透之内。
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公开(公告)号：US20130253546A1
公开(公告)日：2013-09-26
申请号：US13892958
申请日：2013-05-13
IPC分类号： A61B17/12
CPC分类号： A61B17/12009 , A61B17/11 , A61B17/1114 , A61B17/3468 , A61B17/3478 , A61B2017/00278 , A61B2017/0034 , A61B2017/1139 , A61B2017/3486 , A61F2/82 , A61M25/1002 , A61M2025/0096 , A61M2025/09125 , A61M2025/1059
摘要： Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.
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公开(公告)号：US08585771B2
公开(公告)日：2013-11-19
申请号：US11807107
申请日：2007-05-25
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61F2002/044 , A61F2002/045 , A61F2210/0014 , A61N1/36007
摘要： The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.
摘要翻译： 本发明涉及操作有助于抑制食欲和/或减少食物摄取的装置的装置和方法。 在一些实施方案中，本发明的方法和装置包括肠/十二指肠插入物，其包含具有至少一个流动减少元件的细长构件，其可以引起一种或多种饱腹感的生物学信号的刺激。 插入的装置的一些实施例通过驻留在胃中的锚固构件锚定在十二指肠部位，装置的其它实施例通过适当的长度尺寸以及对应的装置的一个或多个成角度的部分而被稳定在目标部位 到达目标地点的角部分。 该装置的实施方案由于物理存在以及通过更积极的干预形式（包括释放生物活性物质和电刺激神经元）而发挥作用。
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公开(公告)号：US20090281557A1
公开(公告)日：2009-11-12
申请号：US12427215
申请日：2009-04-21
申请人： Fiona M. Sander , Michael P. Allen , Matthew Yurek
发明人： Fiona M. Sander , Michael P. Allen , Matthew Yurek
IPC分类号： A61B17/08
CPC分类号： A61B17/12009 , A61B17/11 , A61B17/1114 , A61B17/3468 , A61B17/3478 , A61B2017/00278 , A61B2017/0034 , A61B2017/1139 , A61B2017/3486 , A61F2/82 , A61M25/1002 , A61M2025/0096 , A61M2025/09125 , A61M2025/1059
摘要： Tissue anchors comprise a woven filament braid body having an elongated tubular configuration and a foreshortened configuration where proximal and distal ends of the body expand radially into double-walled flange structures while leaving a cylindrical saddle region therebetween. The tissue anchors are deployed through penetrations between adjacent tissue layers, where the flanges engage the outer surfaces of the tissue layers and the saddle region resides within the tissue penetrations.
摘要翻译： 组织锚固件包括编织长丝编织体，其具有细长的管状构造和缩短构型，其中主体的近端和远端径向扩展成双壁凸缘结构，同时在其间留下圆柱形鞍形区域。 组织锚固件通过相邻组织层之间的穿透进行展开，其中凸缘接合组织层的外表面，并且鞍形区域位于组织穿透之内。
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7.发明申请Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement 失效用于将物质输送到椎间体空间进行核替换的机械装置和方法公开(公告)号：US20090105732A1
公开(公告)日：2009-04-23
申请号：US12316789
申请日：2008-12-16
申请人： Matthew Yurek , Jerome Segal , Kabir Gambhir , Kurt Vedder , Robert Huffman
发明人： Matthew Yurek , Jerome Segal , Kabir Gambhir , Kurt Vedder , Robert Huffman
CPC分类号： A61F2/441 , A61B17/04 , A61B17/064 , A61B17/842 , A61B17/86 , A61B17/869 , A61F2/28 , A61F2/4455 , A61F2/4611 , A61F2002/2835 , A61F2002/30062 , A61F2002/30075 , A61F2002/30092 , A61F2002/302 , A61F2002/30235 , A61F2002/30462 , A61F2002/30464 , A61F2002/30469 , A61F2002/3052 , A61F2002/30579 , A61F2002/30583 , A61F2002/30601 , A61F2002/4435 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0085 , A61F2220/0025 , A61F2220/0075 , A61F2230/0065 , A61F2230/0069 , A61F2310/00011 , A61F2310/00353 , A61F2310/00359 , A61F2310/00365
摘要： The present invention relates to a device and method to perform 1) disk fusing, 2) an artificial replacement of the nucleus, 3) artificial replacement of the annulus, or 4), an artificial replacement of both the nucleus and annulus. The device is designed to be placed into the inter-vertebral space following discectomy. The invention includes a delivery catheter and an expandable continuous mesh that has a torus configuration with a lumen within the mesh and a center hole. The mesh can be diametrically expanded in diameter into the disc space whereby various materials can be injected into the lumen and/or the center hole.
摘要翻译： 本发明涉及一种执行1）盘式定影的装置和方法，2）人造置换核，3）人造置换环，或4）人造置换核和环。 该装置被设计成放置在椎间盘切除术之后的脊椎间隙中。 本发明包括输送导管和可扩张的连续网，其具有环形构型，其具有网内的内腔和中心孔。 网孔可以直径地径向扩大到椎间盘空间中，从而可以将各种材料注入内腔和/或中心孔。
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8.发明申请公开(公告)号：US20070225803A1
公开(公告)日：2007-09-27
申请号：US11676257
申请日：2007-02-16
申请人： Kevin Connors , William Pintauro , Sheila Wallin , John Kilcoyne , Hung Cao , Khoi Nguyen , Matthew Yurek
发明人： Kevin Connors , William Pintauro , Sheila Wallin , John Kilcoyne , Hung Cao , Khoi Nguyen , Matthew Yurek
IPC分类号： A61F2/14
CPC分类号： A61F2/02 , A61F2/042 , A61F9/00781 , A61F2250/0067
摘要： Disclosed herein is an attenuation device comprising a flexible housing and a medium capable of transformation to inflate the housing from the first configuration to the second configuration. Also disclose herein are methods of treating a patient, comprising: providing a self-inflating expandable attenuation device, containing a medium which is transformable from a first, reduced volume to a second, expanded volume; positioning the attenuation device within the patient at a treatment site; and transforming the medium from the first volume to the second volume. In one embodiment, a self-inflating expandable attenuation device is used to treat glaucoma.
摘要翻译： 本文公开了一种衰减装置，其包括柔性壳体和能够转换以使壳体从第一构型向第二构型膨胀的介质。 本文还公开了治疗患者的方法，包括：提供自膨胀的可扩张的衰减装置，其包含可从第一减小的体积转变为第二膨胀体积的介质; 将所述衰减装置定位在患者体内的治疗部位; 并将介质从第一卷转换成第二卷。 在一个实施例中，自充气可扩张衰减装置用于治疗青光眼。
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公开(公告)号：US20070162135A1
公开(公告)日：2007-07-12
申请号：US11700509
申请日：2007-01-31
申请人： Jerome Segal , Matthew Yurek
发明人： Jerome Segal , Matthew Yurek
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61B17/04 , A61B17/064 , A61B17/842 , A61B17/86 , A61B17/869 , A61F2/28 , A61F2/4455 , A61F2/4611 , A61F2002/2835 , A61F2002/30062 , A61F2002/30075 , A61F2002/30092 , A61F2002/302 , A61F2002/30235 , A61F2002/30462 , A61F2002/30464 , A61F2002/30469 , A61F2002/3052 , A61F2002/30579 , A61F2002/30583 , A61F2002/30601 , A61F2002/4435 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0085 , A61F2220/0025 , A61F2220/0075 , A61F2230/0065 , A61F2230/0069 , A61F2310/00011 , A61F2310/00353 , A61F2310/00359 , A61F2310/00365
摘要： The present invention relates to a device and method which may be used to reinforce the native annulus during spinal surgery. The device is a catheter based device which is placed into the inter-vertebral space following discectomy performed by either traditional surgical or endoscopic approaches. The distal end of the catheter is comprised of an expansile loop which may be increased in diameter by advancement of a portion of the catheter via its proximal end, such proximal end remaining external to the body. The expansile loop may be formed such that when the loop is diametrically contracted the loop feeds into its other end, similar to a snake eating its own tail. Stabilization of the outer portion of the loop and pulling out the inner portion will thereby increase the overall diameter of the loop while maintaining it as a closed loop or torus. The expansile loop can use an attachment means to secure it to substantially healthy tissues of the annulus, nucleus, or endplates. The present invention comprises four embodiments and can be used to 1) facilitate disk fusing, 2) perform an artificial replacement of the nucleus, 3) perform an artificial replacement of the annulus, or 4, perform an artificial replacement of both the nucleus and annulus.
摘要翻译： 本发明涉及可用于在脊柱手术期间加强天然环的装置和方法。 该装置是基于导管的装置，其通过传统的手术或内窥镜方法进行椎间盘切除术后放置在脊椎间隙内。 导管的远端包括可膨胀的环，其可以通过导管的一部分的近端前进而直径增加，这样的近端保持在身体外部。 可以形成膨胀环，使得当环径向收缩时，环进入其另一端，类似于吃自己的尾巴的蛇。 因此，环路的外部部分的稳定和拉出内部部分将由此增加环路的总直径，同时将其保持为闭环或环面。 扩张环可以使用附着手段将其固定到环状物，细胞核或终板的基本上健康的组织。 本发明包括四个实施例，并且可以用于1）促进磁盘定影，2）进行人造核替换，3）进行环形的人工置换，或4，进行核和环的人造置换 。
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公开(公告)号：US20060100478A1
公开(公告)日：2006-05-11
申请号：US11314601
申请日：2005-12-20
申请人： Kevin Connors , William Pintauro , Sheila Wallin , John Kilcoyne , Hung Cao , Khoi Nguyen , Matthew Yurek
发明人： Kevin Connors , William Pintauro , Sheila Wallin , John Kilcoyne , Hung Cao , Khoi Nguyen , Matthew Yurek
IPC分类号： A61F2/00
CPC分类号： A61F2/02 , A61F2/042 , A61F9/00781 , A61F2250/0067
摘要： Disclosed herein is an attenuation device, comprising a flexible housing and a high vapor pressure media having a vapor pressure approximately equal to the intravesical pressure of the bladder and a permeability of less than 1 ml/day at body temperature through the outer wall of the flexible housing. In one embodiment, the high vapor pressure media comprises perfluorooctylbromide. In another embodiment, the high vapor pressure media comprises perfluorohexane. In yet another embodiment, the high vapor pressure media comprises perfluorodecalin. Also disclosed herein is a method of treating a patient, comprising providing a compressible attenuation device and introducing within the attenuation device at least one high vapor pressure media.
摘要翻译： 本文公开了一种衰减装置，其包括柔性壳体和高蒸汽压介质，其具有大约等于膀胱的膀胱内压的蒸气压，并且在体温下通过柔性外壁的渗透率小于1ml /天 住房。 在一个实施方案中，高蒸气压介质包含全氟辛基溴。 在另一个实施方案中，高蒸气压介质包括全氟己烷。 在另一个实施方案中，高蒸气压介质包括全氟萘烷。 本文还公开了一种治疗患者的方法，包括提供可压缩衰减装置并在衰减装置内引入至少一个高蒸气压介质。
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