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公开(公告)号：US11668653B2
公开(公告)日：2023-06-06
申请号：US15776649
申请日：2016-11-16
发明人： Patrick Treado , Shona Stewart , Aaron Smith , Heather Gomer
CPC分类号： G01N21/65 , G01J3/0218 , G01J3/0291 , G01J3/2823 , G01J3/44 , G01N21/17 , G01N33/53 , G16H50/20 , G01N2201/0833 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.
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公开(公告)号：US11699220B2
公开(公告)日：2023-07-11
申请号：US17061686
申请日：2020-10-02
发明人： Heather Gomer , Patrick Treado , Jihang Wang
CPC分类号： G06T5/50 , G01N33/4833 , G06T5/007 , H04N5/265 , H04N23/56 , H04N23/80 , H04N23/90 , A61B5/0084 , G06T2207/10024 , G06T2207/10048 , G06T2207/20221 , G06T2207/30004
摘要： Methods, systems, and computer program products of fusing Molecular Chemical Imaging (MCI) and Red Green Blue (RGB) images are disclosed herein. A sample is illuminated with illuminating photons which interact with the sample and are used to form MCI and RGB images. The MCI and RGB images are fused by way of mathematical operations to generate a RGB image with a detection overlay.
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公开(公告)号：US11982568B2
公开(公告)日：2024-05-14
申请号：US17723186
申请日：2022-04-18
发明人： Shawna Tazik , Alyssa Zrimsek , Heather Gomer , Jihang Wang , Patrick J. Treado
CPC分类号： G01J3/2823 , G01J3/10 , G01J2003/283
摘要： Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.
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公开(公告)号：US11307095B2
公开(公告)日：2022-04-19
申请号：US17112393
申请日：2020-12-04
发明人： Shawna Tazik , Alyssa Zrimsek , Heather Gomer , Jihang Wang , Patrick J. Treado
摘要： Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.
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公开(公告)号：US11598717B2
公开(公告)日：2023-03-07
申请号：US17121247
申请日：2020-12-14
发明人： Alyssa Zrimsek , Matthew Nelson , Lei Shi , Heather Gomer , Shawna Tazik
IPC分类号： G01N21/3563 , H04N5/225 , A61B90/00 , A61B90/30 , G01N21/17
摘要： Systems for and methods for detecting samples and other compounds of interest are disclosed herein. The system can include an illumination source that is configured to emit light in a variety of different wavelength bands, an optical filter, a camera chip, and an optical path configured to direct the light emitted by the first illumination source at a target and direct the light reflected from the target to the at least one camera chip. The illumination source and the optical filter are transitionable between a first tuning state corresponding to a target tissue and a second tuning state corresponding to a background tissue. The system can be configured to record images at the different tuning states and generate a score image corresponding to the target tissue based on the recorded images.
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公开(公告)号：US11293802B2
公开(公告)日：2022-04-05
申请号：US17127464
申请日：2020-12-18
发明人： Alyssa Zrimsek , Heather Gomer , Shawna Tazik
摘要： Techniques, devices and methods for discriminating a target from a background material without optimizing directly on the target are provided. The devices and methods can generate pass bands of single or multiple wavelengths of variable shape and intensity, and can also select and control the shape of the pass band profiles to improve the detection of targets of interest.
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公开(公告)号：US11229400B2
公开(公告)日：2022-01-25
申请号：US16544499
申请日：2019-08-19
发明人： Jeffrey Cohen , Patrick Treado , Shona Stewart , Heather Gomer , Arash Samiei , Alyssa Zrimsek , Jihang Wang
摘要： Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.
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