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    Molecular chemical imaging endoscopic imaging systems
    3.
    发明授权
    Molecular chemical imaging endoscopic imaging systems 有权

    公开(公告)号：US10779713B2

    公开(公告)日：2020-09-22

    申请号：US15932435

    申请日：2015-12-09

    申请人： ChemImage Corporation

    发明人： Patrick Treado ,  Matthew Nelson ,  Shona Stewart

    IPC分类号： A61B1/07 ,  A61B1/04 ,  A61B1/06 ,  A61B1/307 ,  A61B1/00

    摘要： The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.

    SYSTEM AND METHOD FOR SERUM BASED CANCER DETECTION
    4.
    发明申请
    SYSTEM AND METHOD FOR SERUM BASED CANCER DETECTION 审中-公开
    基于血清的癌症检测系统及方法

    公开(公告)号：US20150294076A1

    公开(公告)日：2015-10-15

    申请号：US14440987

    申请日：2013-11-06

    申请人： Patrick TREADO ,  Shona STEWART ,  Heather KIRSCHNER ,  Ryan PRIORE ,  Alan WILSON ,  CHEMIMAGE CORPORATION

    发明人： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

    IPC分类号： G06F19/00 ,  G06F19/24 ,  G01N21/65 ,  G01N33/49

    CPC分类号： G16H50/20 ,  G01J3/1804 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/65 ,  G01N33/49 ,  G01N33/57419 ,  G16B40/00

    摘要： A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

    摘要翻译： 用于分析诸如干人血清的生物样品以确定诸如结肠直肠癌（CRC）的疾病状态的系统和方法。 使用干燥的样品可能具有增强样品组分的局部浓度和/或分割的潜力。 该方法可以包括照射生物样品的至少一个位置以产生多个相互作用的光子，收集相互作用的光子并产生代表生物样品的至少一个拉曼数据集。 系统可以包括照明源以照亮生物样品的至少一个位置并且生成至少一个多个相互作用的光子，至少一个反射镜，用于将相互作用的光子引导到检测器。 检测器可以被配置为产生代表生物样品的至少一个拉曼数据集。 该系统和方法可以利用FAST设备进行多点分析，或者可以配置为使用线扫描配置分析样本。

    Molecular chemical imaging endoscopic imaging systems
    8.
    发明授权
    Molecular chemical imaging endoscopic imaging systems 有权

    公开(公告)号：US11234584B2

    公开(公告)日：2022-02-01

    申请号：US15374769

    申请日：2016-12-09

    申请人： ChemImage Corporation

    发明人： Patrick Treado ,  Shona Stewart ,  Matthew P. Nelson

    IPC分类号： A61B1/07 ,  A61B1/06 ,  A61B5/00 ,  A61B1/04 ,  A61B1/00

    摘要： Medical imaging systems for use in conjunction with an endoscope are described. Generally, the medical imaging system includes an illumination source configured to generate illuminating photons. The illuminating photons are transmitted to one or more filters configured to filter a first plurality of illuminating photons and generate a first plurality of filtered photons comprising a first passband wavelength and a second plurality of filtered photons comprising a second passband wavelength. A sample is then illuminated with the first plurality of filtered photons and the second plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons. One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons and generate one or more image data sets.

    System and method for serum based cancer detection
    9.
    发明授权
    System and method for serum based cancer detection 有权

    公开(公告)号：US11145411B2

    公开(公告)日：2021-10-12

    申请号：US14440987

    申请日：2013-11-06

    申请人： CHEMIMAGE CORPORATION ,  Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

    发明人： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

    IPC分类号： G01N21/65 ,  G01N33/49 ,  G16H50/20 ,  G16B40/00 ,  G01N33/574 ,  G01J3/44 ,  G01J3/18

    摘要： A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.