利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.032 秒)

    Inducing cell apoptosis and treating cancer using 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone
    1.
    发明授权
    Inducing cell apoptosis and treating cancer using 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone 失效
    诱导细胞凋亡和使用1-O-乙酰胆碱酯内酯或1,6-O，O-二乙酰胆碱酯

    公开(公告)号：US06627623B2

    公开(公告)日：2003-09-30

    申请号：US10079038

    申请日：2002-02-20

    申请人： Chi-Tang Ho ,  Mohammed Rafi ,  Robert S. Dipaola ,  Geetha Ghai ,  Robert T. Rosen ,  Naisheng Bai

    发明人： Chi-Tang Ho ,  Mohammed Rafi ,  Robert S. Dipaola ,  Geetha Ghai ,  Robert T. Rosen ,  Naisheng Bai

    IPC分类号： A61K3578

    CPC分类号： A61K36/28

    摘要： Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom. The compounds of 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone are isolated and used for inducing apoptosis in cells and for treating cancer in an animal. Induction of apoptosis comprises contacting cells with a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation. Further, treatment of cancer in an animal comprises administering to an animal a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation to treat the cancer.

    摘要翻译： 提供了预防和治疗癌症的组合物和方法，所述组合物和方法包含英国不丹或从其分离的化合物的提取物。 分离出1-O-乙酰基天宁内酯或1,6- O，O-二乙酰胆碱酯的化合物，用于诱导细胞凋亡和用于治疗动物的癌症。 诱导凋亡包括使细胞与包含化合物的组合物以足以诱导Bcl-2蛋白磷酸化的量接触。 此外，动物中癌症的治疗包括向动物施用包含足以诱导Bcl-2蛋白磷酸化以治疗癌症的量的化合物的组合物。

    Methods of screening foods for nutraceuticals
    7.
    发明授权
    Methods of screening foods for nutraceuticals 失效
    筛选营养品食品的方法

    公开(公告)号：US5955269A

    公开(公告)日：1999-09-21

    申请号：US670826

    申请日：1996-06-20

    申请人： Geetha Ghai ,  Charles Boyd ,  Katalin Csiszar ,  Chi-Tang Ho ,  Robert T. Rosen

    发明人： Geetha Ghai ,  Charles Boyd ,  Katalin Csiszar ,  Chi-Tang Ho ,  Robert T. Rosen

    IPC分类号： A23L1/30 ,  C12N15/82 ,  C12Q1/68 ,  G01N33/50 ,  A23L1/00 ,  C12P19/34

    CPC分类号： G01N33/5097 ,  A23L33/10 ,  A23L33/105 ,  C12N15/8242 ,  C12Q1/6897 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5088 ,  A23V2002/00

    摘要： The invention relates to an assay system for screening nutraceuticals, i.e., foods or food substances that occur naturally, or that are produced during processing which are capable of modulating in a subject the expression of one or more genes associated with a disease or undesirable physical condition. The nutraceuticals identified by the screening assays can be incorporated into compositions which may be administered to a subject to treat or prevent a disease or undesirable condition, or otherwise to improve the health of the subject. The invention further provides methods for modifying the amount of nutraceuticals in raw and processed foods or food substances.

    摘要翻译： 本发明涉及用于筛选营养品的测定系统，即天然存在的或在加工过程中产生的食物或食物，其能够在受试者中调节与疾病或不期望的身体状况相关的一种或多种基因的表达 。 通过筛选测定鉴定的营养药物可以并入可以施用于受试者以治疗或预防疾病或不良状况或以其他方式改善受试者健康的组合物中。 本发明进一步提供了用于改变生加工食品或食品中营养药物量的方法。