利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

72 条记录 (耗时 0.037 秒)

    Peptides having ligand activities on APJ that is an orphan G protein-coupled receptor, and use thereof
    1.
    发明授权
    Peptides having ligand activities on APJ that is an orphan G protein-coupled receptor, and use thereof 失效
    具有作为孤儿G蛋白偶联受体的APJ上的配体活性的肽及其用途

    公开(公告)号：US07635751B2

    公开(公告)日：2009-12-22

    申请号：US10239321

    申请日：2001-03-22

    申请人： Chieko Kitada ,  Naoki Nishizawa ,  Shuji Hinuma ,  Masaki Hosoya

    发明人： Chieko Kitada ,  Naoki Nishizawa ,  Shuji Hinuma ,  Masaki Hosoya

    IPC分类号： C07K7/06 ,  C07K7/08 ,  A61K38/08 ,  A61K38/10

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/47

    摘要： The present invention relates to novel peptide derivatives, which are recognized as ligands to G-coupled protein receptor proteins.The peptide of the present invention can be used in (1) development of a receptor binding assay system using the expression system of the recombinant receptor protein and screening of candidates for pharmaceutical compounds, and (2) development of pharmaceutical preparations such as a neutral nerve function regulator, a circulatory function regulator, a cardiac function regulator, an immune function regulator, a digestive organ function regulator, a metabolic function regulator, a generative organ regulator or the like.

    摘要翻译： 本发明涉及新的肽衍生物，其被认为是G偶联蛋白受体蛋白质的配体。 本发明的肽可以用于（1）使用重组受体蛋白质的表达系统开发受体结合测定系统并筛选药物化合物的候选物，和（2）开发药物制剂如中性神经 功能调节剂，循环功能调节剂，心脏功能调节剂，免疫功能调节剂，消化器官功能调节剂，代谢功能调节剂，生殖器官调节剂等。

    Polypeptides their production and use
    4.
    发明授权
    Polypeptides their production and use 失效
    多肽的生产和使用

    公开(公告)号：US06228984B1

    公开(公告)日：2001-05-08

    申请号：US08776971

    申请日：1997-02-07

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K1447

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    Polypeptides, their production and use
    7.
    发明授权
    Polypeptides, their production and use 失效
    多肽，其生产和使用

    公开(公告)号：US06881545B1

    公开(公告)日：2005-04-19

    申请号：US09716147

    申请日：2000-11-17

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K14/575 ,  C07K14/705 ,  G01N33/53 ,  C07K7/08 ,  C07K14/72

    CPC分类号： C07K14/705 ,  C07K14/575

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins.The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds.In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物，例如垂体功能调节剂，中枢神经系统功能调节剂和胰功能调节剂，以及（2）开发受体结合测定系统，其使用 重组受体蛋白的表达和药物候选化合物的筛选。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    G protein-coupled receptor protein, its DNA and ligand thereof
    9.
    发明授权
    G protein-coupled receptor protein, its DNA and ligand thereof 失效
    G蛋白偶联受体蛋白，其DNA及其配体

    公开(公告)号：US07192723B2

    公开(公告)日：2007-03-20

    申请号：US10719587

    申请日：2003-11-21

    申请人： Takuya Watanabe ,  Kuniko Kikuchi ,  Yasuko Terao ,  Yasushi Shintani ,  Shuji Hinuma ,  Shoji Fukusumi ,  Ryo Fujii ,  Masaki Hosoya ,  Chieko Kitada

    发明人： Takuya Watanabe ,  Kuniko Kikuchi ,  Yasuko Terao ,  Yasushi Shintani ,  Shuji Hinuma ,  Shoji Fukusumi ,  Ryo Fujii ,  Masaki Hosoya ,  Chieko Kitada

    IPC分类号： C07K7/08 ,  C07K14/47 ,  G01N33/566

    CPC分类号： C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

    摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

    摘要翻译： 本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如 作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤 肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。