公开(公告)号：US20200237938A1

公开(公告)日：2020-07-30

申请号：US16215647

申请日：2018-12-11

申请人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

发明人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

IPC分类号： A61K51/08 ,  A61K51/04 ,  A61K51/06

摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga, 67Ga, 68Ga, 177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.

公开(公告)号：USD725487S1

公开(公告)日：2015-03-31

申请号：US29494573

申请日：2014-06-23

申请人： Chih-Hsien Chang

设计人： Chih-Hsien Chang

公开(公告)号：US20150033828A1

公开(公告)日：2015-02-05

申请号：US13956375

申请日：2013-08-01

申请人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

发明人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

IPC分类号： G01N15/08

CPC分类号： B01D65/102 ,  B01D65/10 ,  G01M3/06

摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.

摘要翻译： 一种用于药物过滤膜的风险和完整性测试的自动测试装置，包括至少以下组件：液体注射入口，泵，流体压力计，气体压力计，多个电磁阀，多个膜， 气体压力调节阀，药品瓶和气泡生成瓶。 本发明的自动测试装置由计算机软件与用于自动化测试的自动药物合成装置有关。 在使用本发明的自动测试装置时，仅需要在自动药物合成完成之后启动用于膜风险和完整性测试的自动测试装置的操作系统。 薄膜风险和完整性测试可以在短时间内通过测量气体和液体的压力同时在线排出的压力计来完成。

公开(公告)号：US08589831B1

公开(公告)日：2013-11-19

申请号：US13561189

申请日：2012-07-30

申请人： Chih-Hsien Chang ,  Min-Shueh Yuan ,  Tsung-Hsien Tsai

发明人： Chih-Hsien Chang ,  Min-Shueh Yuan ,  Tsung-Hsien Tsai

IPC分类号： G06F17/50

CPC分类号： G06F17/5068

摘要： Some aspects of the present disclosure provide for a method of accurately simulating variations in an operating parameter, due to processing variations caused by a multi-patterning exposure, by reducing the impact of layout sections having a large width and spacing. The method assigns a skew sensitive index to one or more sections of a multi-patterning layer formed with a first mask. Runlengths of the one or more sections are respectively multiplied by an assigned skew sensitive index to determine a skew variation for each of the one or more sections. The overall skew variation sum is then determined by summing the skew variation for each of the one or more sections. By separately determining the effects of processing variations (e.g., mask misalignment) for different sections of a multi-patterning layer, an accurate measurement of operating parameter variations is achieved.

摘要翻译： 本公开的一些方面提供了通过减小​​具有大的宽度和间隔的布局部分的影响，由于由多图案化曝光引起的处理变化，准确地模拟操作参数的变化的方法。 该方法为由形成有第一掩模的多图案化层的一个或多个部分分配偏斜敏感指数。 一个或多个部分的运行长度分别乘以一个分配的偏移敏感指数，以确定一个或多个部分中的每个部分的偏斜变化。 然后通过对一个或多个部分中的每一个的偏斜变化求和来确定总体偏差变化和。 通过分别确定多图案化层的不同部分的处理变化（例如，掩模未对准）的影响，实现了操作参数变化的精确测量。

公开(公告)号：US08510701B2

公开(公告)日：2013-08-13

申请号：US13350894

申请日：2012-01-16

申请人： Chen-Ting Ko ,  Chih-Hsien Chang ,  Yung-Chow Peng

发明人： Chen-Ting Ko ,  Chih-Hsien Chang ,  Yung-Chow Peng

IPC分类号： G06F17/50

CPC分类号： G06F17/5045 ,  G06F2217/78

摘要： Some aspects of this disclosure provide for electronic design automation (EDA) techniques that check whether individual blocks, such as transistors or other semiconductor devices, are connected to their correct power domains during design. In this way, the disclosed EDA techniques can limit or prevent overstress conditions applied to blocks and help to improve reliability of integrated circuits, when manufactured.

摘要翻译： 本公开的一些方面提供了电子设计自动化（EDA）技术，其在设计期间检查诸如晶体管或其他半导体器件的各个块是否连接到其正确的电源域。 以这种方式，所公开的EDA技术可以限制或防止在制造时应用于块的过应力条件并有助于提高集成电路的可靠性。

公开(公告)号：US08482332B2

公开(公告)日：2013-07-09

申请号：US13089160

申请日：2011-04-18

申请人： Yung-Chow Peng ,  Min-Shueh Yuan ,  Chih-Hsien Chang

发明人： Yung-Chow Peng ,  Min-Shueh Yuan ,  Chih-Hsien Chang

IPC分类号： H03K3/00

CPC分类号： H03K5/15066 ,  H03K5/133 ,  H03K2005/00058 ,  H03L7/06

摘要： An embodiment is an integrated circuit. The integrated circuit comprises a clock generator and data transmission lines. The clock generator generates clock signals. At least some of the clock signals have a phase difference from an input clock signal input into the clock generator, and at least some of the clock signals have a different phase difference with respect to at least another of the clock signals. Each of the data transmission lines is triggered at least in part by at least one of the clock signals.

摘要翻译： 实施例是集成电路。 集成电路包括时钟发生器和数据传输线。 时钟发生器产生时钟信号。 至少一些时钟信号具有与输入到时钟发生器的输入时钟信号的相位差，并且至少一些时钟信号相对于至少另一个时钟信号具有不同的相位差。 至少部分地通过至少一个时钟信号来触发每个数据传输线。

公开(公告)号：US08302060B2

公开(公告)日：2012-10-30

申请号：US12947938

申请日：2010-11-17

申请人： Renjeng Chiang ,  Chih-Hsien Chang

发明人： Renjeng Chiang ,  Chih-Hsien Chang

IPC分类号： G06F17/50

CPC分类号： G06F17/5072 ,  G06F2217/40

摘要： A system includes a computer readable storage medium and a processor. The computer readable storage includes data representing an input/output (“I/O”) cell of a first type for modeling and/or fabricating a semiconductor device. The I/O cell of the first type includes circuitry for providing a first plurality of functions. The processor is in communication with the computer readable storage medium and is configured to select the I/O cell of the first type, arrange a plurality of the I/O cells of the first type on a model of an semiconductor device, and store the model of the semiconductor device including the plurality of the I/O cells of the first type in the computer readable storage medium.

摘要翻译： 系统包括计算机可读存储介质和处理器。 计算机可读存储器包括表示用于建模和/或制造半导体器件的第一类型的输入/输出（I / O）单元的数据。 第一类型的I / O单元包括用于提供第一多个功能的电路。 处理器与计算机可读存储介质通信，并且被配置为选择第一类型的I / O单元，将第一类型的多个I / O单元布置在半导体器件的型号上，并存储 包括计算机可读存储介质中第一类型的多个I / O单元的半导体器件的型号。

公开(公告)号：US20080102110A1

公开(公告)日：2008-05-01

申请号：US11608836

申请日：2006-12-10

申请人： Te-Wei Lee ,  Shu-Pei Chiu ,  Chiu-Yu Yu ,  Tsui-Jung Chang ,  Chih-Hsien Chang

发明人： Te-Wei Lee ,  Shu-Pei Chiu ,  Chiu-Yu Yu ,  Tsui-Jung Chang ,  Chih-Hsien Chang

IPC分类号： A61K9/127 ,  C07K7/08 ,  C07K7/06

CPC分类号： A61K9/1271 ,  A61K9/1278 ,  A61K47/62 ,  A61K47/6911 ,  C07K14/6555 ,  Y02P20/55

摘要： The present invention discloses a method for preparing lipid-spacer-reactive functional group-peptide, whereinthe peptide consists of 3 to 16 amino acid residues in which at least one amino acid residue is lysine (Lys), the reactive functional group is a formula of —X—CO—Y—CO—, wherein X represents an oxygen atom or a nitrogen atom, and Y represents C1-6 alkylene which may be interrupted by one or two oxygen or nitrogen atom(s), the spacer is a hydrophilic polymer, and the lipid is phosphatidylethanoaminecarbonyl represented by the formula (I): R1 and R2 are the same or different and individually represent linear or branch C7-30 alkyl or linear or branch C7-30 alkenyl; which is characterized in that the reaction is carried out in a liquid phase and comprises the following steps of (a) firstly protecting Lys amino acid residue in the peptide through a protection group; (b) subsequently reacting the peptide with the lipid-spacer-reactive functional group; and (c) finally removing the protection group from Lys amino acid residue in the peptide.

公开(公告)号：US20080018350A1

公开(公告)日：2008-01-24

申请号：US11525581

申请日：2006-09-22

申请人： Clinton Chao ,  Chih-Hsien Chang ,  John C.Y. Chiang ,  Mark Shane Peng ,  Hua-Shu Wu ,  Kim Chen ,  Wen-Hung Wu ,  Tjandra Winada Karta

发明人： Clinton Chao ,  Chih-Hsien Chang ,  John C.Y. Chiang ,  Mark Shane Peng ,  Hua-Shu Wu ,  Kim Chen ,  Wen-Hung Wu ,  Tjandra Winada Karta

IPC分类号： G01R31/02

CPC分类号： G01R1/07378

摘要： An interposer for converting pitches includes an interconnect structure over the semiconductor substrate, an active circuit formed on the semiconductor substrate, wherein the active circuit is electrically connected to the interconnect structure, a first plurality of pads with a first pitch over the interconnect structure, a second plurality of pads underlying the semiconductor substrate, and a plurality of through-substrate vias in the semiconductor substrate, wherein the first and the second plurality of pads are interconnected through the plurality of through-substrate vias.

摘要翻译： 用于转换间距的插入件包括半导体衬底上的互连结构，形成在半导体衬底上的有源电路，其中有源电路电连接到互连结构，在互连结构上具有第一间距的第一多个焊盘， 半导体衬底下面的第二多个衬垫，以及半导体衬底中的多个穿通衬底通孔，其中第一和第二多个焊盘通过多个贯穿衬底通孔互连。

公开(公告)号：US06719619B2

公开(公告)日：2004-04-13

申请号：US09846641

申请日：2001-05-01

申请人： Ching-Hui Kuo ,  Jheng-Tong Wu ,  Chih-Hsien Chang

发明人： Ching-Hui Kuo ,  Jheng-Tong Wu ,  Chih-Hsien Chang

IPC分类号： B24B100

CPC分类号： B24B53/017 ,  B24B45/006 ,  B24B53/12 ,  Y10T279/17411 ,  Y10T279/17752

摘要： A quick coupler for mounting a rotational disk which enables the rotational disk to be quick connect to or disconnect from a pad conditioner disk holder is disclosed. The quick coupler consists of two major components of a disk holder and a travel housing. The disk holder is formed in a ring shape having a center aperture in a polygon shape for intimately engaging a polygon-shaped shaft of the travel housing such that a rotational torque can be transmitted from the travel housing to the disk holder. Each side of the polygon is provided with a steel ball and a recessed slot behind the ball for receiving a jutting key operated by a retractable ring attached to the travel housing. The travel housing is formed in a cylindrical shape that has a first end threaded for engaging a drive means and a second end in the polygon shape.

摘要翻译： 公开了一种用于安装旋转盘的快速联接器，其使得旋转盘能够快速地连接到垫调节器盘保持器或从垫调节器盘保持器脱离。 快速耦合器由盘保持器和行进壳体的两个主要部件组成。 盘保持器形成为具有多边形形状的中心孔的环形，用于紧密地接合行进壳体的多边形轴，使得旋转扭矩可以从行驶壳体传递到盘保持器。 多边形的每一侧都设有一个钢球和一个在球后面的凹槽，用于接收一个伸出的钥匙，该钥匙由一个附着在行驶箱上的伸缩环操作。 移动壳体形成为圆柱形，其具有螺纹用于接合驱动装置的第一端和多边形形状的第二端。